Cannabis, HIV and Mental Processing Systems (CHAMPS)

大麻、艾滋病毒和心理处理系统 (CHAMPS)

• 批准号: 10261977
• 负责人: Beau M Ances
• 金额: $ 64.42万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10261977
• 关键词: Affect; Brain; CCL2 gene; CD14 gene; CD4/CD8 ratio procedure; CD8-Positive T-Lymphocytes; Cannabidiol; Cannabis; Cellularity; Classification; Cognition; Complex; Conflict (Psychology); Counseling; Cross-Sectional Studies; Data; Dimensions; Employment; Exposure to; General Population; HIV; HIV Infections; Health; Hippocampus (Brain); Immune; Immunologic Markers; Impaired cognition; Inflammation; Learning; Legal; Life; Measurement; Measures; Medical Marijuana; Memory; Methodology; Methods; Modeling; Neopterin; Neuropsychology; Outcome; Parietal Lobe; Perforant Pathway; Performance; Peripheral; Persons; Pharmaceutical Preparations; Phenotype; Plasma; Prevalence; Prevention Guidelines; Psyche structure; Qualifying; Recreational Drugs; Reporting; Research Design; Sampling; Science; Short-Term Memory; Structure; Survival Rate; System; THC concentration; Temporal Lobe; Testing; Tetrahydrocannabinol; Time; Urine; Viral; antiretroviral therapy; cognitive performance; executive function; immune activation; immune function; immune health; improved; indexing; insight; macrophage; marijuana use; marijuana user; monocyte; neuroimaging; novel; phenotypic data; programs; substance use; treatment guidelines

ABSTRACT/PROJECT SUMMARY This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). Our overall hypothesis is that cannabis use leads to increases in inflammation in the peripheral and brain compartments. We also hypothesize that phenotypic signatures due to regular cannabis use and HIV will be delineated through NP and brain volumetrics. In Aim 1 we hypothesize that regular cannabis use will increase both peripheral and brain immune indices in PLWH on cART. In Aim 2 we hypothesize that regular cannabis use will lead to a worsening of NP and reductions in brain volumetrics in both PLWH on cART and HIV- controls. This proposal will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.

摘要/项目总结 该提案采用了新的方法来确定并发艾滋病毒的关键决定因素和后果 感染和经常使用大麻。我们将从外周和大脑中获得广泛的表型数据， 免疫激活，大脑结构和神经心理学表现（NP）的标志物， 接受抗逆转录病毒联合疗法（cART）的艾滋病毒感染者（PLWH）（80名经常使用大麻者和80名 非使用者）和未感染艾滋病毒（艾滋病毒-）的对照组（80名经常使用大麻者和80名非使用者）。我们的整体 一种假设是，大麻的使用导致外周和脑区室的炎症增加。 我们还假设，由于经常使用大麻和艾滋病毒的表型签名将通过以下方式来描述： NP和脑容量。在目标1中，我们假设定期使用大麻会增加外周和 PLWH患者接受cART治疗时的脑免疫指标。在目标2中，我们假设定期使用大麻会导致 在接受cART的PLWH和HIV对照中，NP恶化和脑体积减少。这项建议 将提供关于常规大麻和艾滋病毒对外周和大脑标记物的影响的关键见解。 PLWH和HIV对照中免疫功能和NP。这些见解对于治疗策略至关重要， 正在进行的艾滋病毒治疗活动。