Cannabis, HIV and Mental Processing Systems (CHAMPS)
大麻、艾滋病毒和心理处理系统 (CHAMPS)
基本信息
- 批准号:10261977
- 负责人:
- 金额:$ 64.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-08-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:AffectBrainCCL2 geneCD14 geneCD4/CD8 ratio procedureCD8-Positive T-LymphocytesCannabidiolCannabisCellularityClassificationCognitionComplexConflict (Psychology)CounselingCross-Sectional StudiesDataDimensionsEmploymentExposure toGeneral PopulationHIVHIV InfectionsHealthHippocampus (Brain)ImmuneImmunologic MarkersImpaired cognitionInflammationLearningLegalLifeMeasurementMeasuresMedical MarijuanaMemoryMethodologyMethodsModelingNeopterinNeuropsychologyOutcomeParietal LobePerforant PathwayPerformancePeripheralPersonsPharmaceutical PreparationsPhenotypePlasmaPrevalencePrevention GuidelinesPsyche structureQualifyingRecreational DrugsReportingResearch DesignSamplingScienceShort-Term MemoryStructureSurvival RateSystemTHC concentrationTemporal LobeTestingTetrahydrocannabinolTimeUrineViralantiretroviral therapycognitive performanceexecutive functionimmune activationimmune functionimmune healthimprovedindexinginsightmacrophagemarijuana usemarijuana usermonocyteneuroimagingnovelphenotypic dataprogramssubstance usetreatment guidelines
项目摘要
ABSTRACT/PROJECT SUMMARY
This proposal employs novel methods to identify key determinants and consequences of concurrent HIV
infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain
markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living
with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80
non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). Our overall
hypothesis is that cannabis use leads to increases in inflammation in the peripheral and brain compartments.
We also hypothesize that phenotypic signatures due to regular cannabis use and HIV will be delineated through
NP and brain volumetrics. In Aim 1 we hypothesize that regular cannabis use will increase both peripheral and
brain immune indices in PLWH on cART. In Aim 2 we hypothesize that regular cannabis use will lead to a
worsening of NP and reductions in brain volumetrics in both PLWH on cART and HIV- controls. This proposal
will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of
immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and
ongoing HIV treatment initiatives.
摘要/项目总结
该提案采用了新的方法来确定并发艾滋病毒的关键决定因素和后果
感染和经常使用大麻。我们将从外周和大脑中获得广泛的表型数据,
免疫激活,大脑结构和神经心理学表现(NP)的标志物,
接受抗逆转录病毒联合疗法(cART)的艾滋病毒感染者(PLWH)(80名经常使用大麻者和80名
非使用者)和未感染艾滋病毒(艾滋病毒-)的对照组(80名经常使用大麻者和80名非使用者)。我们的整体
一种假设是,大麻的使用导致外周和脑区室的炎症增加。
我们还假设,由于经常使用大麻和艾滋病毒的表型签名将通过以下方式来描述:
NP和脑容量。在目标1中,我们假设定期使用大麻会增加外周和
PLWH患者接受cART治疗时的脑免疫指标。在目标2中,我们假设定期使用大麻会导致
在接受cART的PLWH和HIV对照中,NP恶化和脑体积减少。这项建议
将提供关于常规大麻和艾滋病毒对外周和大脑标记物的影响的关键见解。
PLWH和HIV对照中免疫功能和NP。这些见解对于治疗策略至关重要,
正在进行的艾滋病毒治疗活动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Beau M Ances其他文献
Prediction of amyloid and tau brain deposition and cognitive decline in people with Down syndrome using plasma biomarkers: a longitudinal cohort study
利用血浆生物标志物预测唐氏综合征患者的淀粉样蛋白和tau 蛋白脑沉积及认知能力下降:一项纵向队列研究
- DOI:
10.1016/s1474-4422(25)00158-9 - 发表时间:
2025-07-01 - 期刊:
- 影响因子:45.500
- 作者:
Shorena Janelidze;Lyduine E Collij;Niklas Mattsson-Carlgren;Alex Antill;Charles M Laymon;Ira Lott;H Diana Rosas;Davneet S Minhas;Weiquan Luo;Shahid Zaman;Alzheimer's Biomarker Consortium–Down Syndrome investigators;Mark Mapstone;Elizabeth Head;Florence Lai;Sigan L Hartley;Beau M Ances;Sharon J Krinsky-McHale;Joseph H Lee;Rik Ossenkoppele;Bradley T Christian;Benjamin L Handen;Oskar Hansson - 通讯作者:
Oskar Hansson
Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study
唐氏综合征患者症状性阿尔茨海默病的时间线(通过淀粉样蛋白-PET 和 tau-PET 评估):一项纵向队列研究
- DOI:
10.1016/s1474-4422(24)00426-5 - 发表时间:
2024-12-01 - 期刊:
- 影响因子:45.500
- 作者:
Emily K Schworer;Matthew D Zammit;Jiebiao Wang;Benjamin L Handen;Tobey Betthauser;Charles M Laymon;Dana L Tudorascu;Annie D Cohen;Shahid H Zaman;Beau M Ances;Mark Mapstone;Elizabeth Head;Bradley T Christian;Sigan L Hartley;Howard Aizenstein;Beau Ances;Howard Andrews;Karen Bell;Rasmus Birn;Adam Brickman;Fan Zhang - 通讯作者:
Fan Zhang
Technology Insight: can neuroimaging provide insights into the role of ischemia in Baló's concentric sclerosis?
技术洞察:神经影像学能否为缺血在巴尔通体同心性硬化中的作用提供见解?
- DOI:
10.1038/ncpneuro0519 - 发表时间:
2007-06-01 - 期刊:
- 影响因子:33.100
- 作者:
Ellen M Mowry;John H Woo;Beau M Ances - 通讯作者:
Beau M Ances
Beau M Ances的其他文献
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{{ truncateString('Beau M Ances', 18)}}的其他基金
Cannabis, HIV and Mental Processing Systems (CHAMPS)
大麻、艾滋病毒和心理处理系统 (CHAMPS)
- 批准号:
10458095 - 财政年份:2021
- 资助金额:
$ 64.42万 - 项目类别:
VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)
衰老成人大脑连接体 (AABC) 的脆弱性和弹性
- 批准号:
10283063 - 财政年份:2021
- 资助金额:
$ 64.42万 - 项目类别:
Cannabis, HIV and Mental Processing Systems (CHAMPS)
大麻、艾滋病毒和心理处理系统 (CHAMPS)
- 批准号:
10625336 - 财政年份:2021
- 资助金额:
$ 64.42万 - 项目类别:
VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)
衰老成人大脑连接体 (AABC) 的脆弱性和弹性
- 批准号:
10673890 - 财政年份:2021
- 资助金额:
$ 64.42万 - 项目类别:
Project 1: Biomarkers for Characterizing and Predicting AD in DS
项目 1:用于表征和预测 DS 中 AD 的生物标志物
- 批准号:
10264842 - 财政年份:2020
- 资助金额:
$ 64.42万 - 项目类别:
Project 1: Biomarkers for Characterizing and Predicting AD in DS
项目 1:用于表征和预测 DS 中 AD 的生物标志物
- 批准号:
10454259 - 财政年份:2020
- 资助金额:
$ 64.42万 - 项目类别:
Project 1: Biomarkers for Characterizing and Predicting AD in DS
项目 1:用于表征和预测 DS 中 AD 的生物标志物
- 批准号:
10667598 - 财政年份:2020
- 资助金额:
$ 64.42万 - 项目类别:
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