VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)

概述摘要 老龄成人脑连接体(AABC)利用人类开发的现有基础设施 连接组老龄化项目(HCP-A)通过获得纵向随访数据(神经成像、认知测试、 和血液)使用标准化的方案，从1,000多名健康个体组成的良好队列中 在参与者内部生成长达10年的大脑轨迹。在最初的招募中，参加 HCP-A通常身体和认知健康，但随着时间的推移，一些人会发展为临床前AD或早期 AD或ADRD引起的认知改变。AABC由四个项目组成：项目1检查影响 应激和变态负荷，包括炎症，在成体早期。项目2检查了这些影响 生活方式行为在成年中期的认知和大脑变化的轨迹上。项目3 检查更年期过渡/血管舒缩症状在成年中期的影响。项目4考试- 成年后几十年对AD和ADRD的临床和神经指标的弹性和抵抗力 胡德。AABC还包括4个核心：行政核心(AC)将提供必要的核心和站点 领导履行AABC的科学使命。多样性招募和留住股(DRRU) 将设在这一核心内，并将确保AABC继续招聘和保留适当的分部- 但目前在美国看到的是比赛的反响。综合数据采集核心(IDAC)提供专业知识 和来自每个地点的人员，以获得高质量的神经成像，对非成像数据进行深入的表型分析，以及 每个站点的生物样本。信息学、数据分析和统计核心(IDASC)将容纳项目图像- 使用IntraDB数据库的ING数据，将执行原始和分析数据的质量控制，将开发和运行 为每个项目生成多模式成像数据表型的横截面和纵向管道，将 提供降维摘要，将计算丢失的数据；并将开发和运行统计模型 每个项目。IDASC还将负责与公众共享数据。遗传学和 多组学样本核心(GMSC)将提供参与者的遗传信息，通过 AABC已经使用统一的协议来描述他们的特征。多组数据和AD生物标记物数据将 由GMSC生成。

ABSTRACT FOR OVERVIEW The Aging Adult Brain Connectome (AABC) leverages the existing infrastructure developed by the Human Connectome Project for Aging (HCP-A) by obtaining longitudinal follow-up data (neuroimaging, cognitive testing, and blood) using a standardized protocol from a well characterized cohort of over 1,000 healthy individuals to generate within-participant brain trajectories for up to 10 years. At initial recruitment, individuals enrolled in the HCP-A were generally physically and cognitively healthy but over time some will develop preclinical AD or early cognitive changes due to AD or ADRD. The AABC is comprised of four Projects: Project 1 examine the effects of stress and allostatic load, including inflammation, during the early adult period. Project 2 examines the effects of lifestyle behaviors on the trajectory of cognitive and brain changes during the mid adult period. Project 3 examine the effects of menopause transition/vasomotor symptoms during the mid adult period. Project 4 exam- ine the clinical and neural indicators of resiliency and resistance to AD and ADRD in the later decades of adult- hood. The AABC also consists of 4 Cores: The Administration Core (AC) will provide essential core and site leadership to carry out the scientific mission of the AABC. The diversity recruitment and retention unit (DRRU) will be located within this core and will ensure that the AABC continues to recruit and retain an adequate distri- bution of races that is currently seen in the US. The Integrated Data Acquisition Core (IDAC) provides expertise and personnel from each site to acquire high quality neuroimaging, deep phenotyping of non-imaging data, and biosamples from each site.The Informatics, Data Analysis, and Statistics Core (IDASC) will house project imag- ing data using the IntraDB database, will perform quality control of raw and analyzed data, will develop and run cross-sectional and longitudinal pipelines to produce multi-modal imaging data phenotypes for each project, will provide dimension-reduced summaries, will impute missing data; and will develop and run statistical models for each project. The IDASC will also be responsible for data sharing with the general public. The Genetics and Multi-omics Specimens Core (GMSC) will provide genetic information on participants evaluated through the AABC who have been characterized using a uniform protocol. Multi-omic data and AD biomarker data will be generated by the GMSC.