VULNERABILITY AND RESILIENCY IN THE AGING ADULT BRAIN CONNECTOME (AABC)

衰老成人大脑连接体 (AABC) 的脆弱性和弹性

• 批准号: 10283063
• 负责人: Beau M Ances
• 金额: $ 664.05万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10283063
• 关键词: Adult; Affect; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Behavior; Biological; Biological Markers; Blood; Blood Pressure; Brain; Centenarian; Clinical; Cognition; Cognitive; Communities; Conceptions; Data; Data Analyses; Databases; Dementia; Development; Diet; Dimensions; Disease; Elderly; Enrollment; Ensure; Foundations; Funding; General Population; Genetic; Genetic Markers; Goals; Health; Human; Human Resources; Image; Image Analysis; Impaired cognition; Impairment; Individual; Inflammation; Informatics; Infrastructure; Leadership; Life; Life Style; Light; Longevity; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Menopause; Mission; Multimodal Imaging; Multiomic Data; Neurocognitive; Participant; Partner in relationship; Pathology; Pattern; Phase Transition; Phenotype; Physical activity; Physiological; Plasma; Population; Postmenopause; Protocols documentation; Quality Control; Race; Request for Applications; Research Personnel; Resistance; Resolution; Resources; Risk; Risk Factors; Running; Sampling; Site; Specimen; Standardization; Statistical Models; Stress; Structure; Symptoms; Time; Underrepresented Populations; United States National Institutes of Health; Vasomotor; Woman; aged; allostatic load; base; cognitive change; cognitive testing; cohort; connectome; data acquisition; data sharing; data sharing networks; follow-up; genetic information; multiple omics; neurochemistry; neurofilament; neuroimaging; neuroinflammation; novel; phenotypic data; physical inactivity; pre-clinical; preservation; psychologic; recruit; relating to nervous system; resilience; response; sex; sleep quality; social; statistics; tau-1

ABSTRACT FOR OVERVIEW The Aging Adult Brain Connectome (AABC) leverages the existing infrastructure developed by the Human Connectome Project for Aging (HCP-A) by obtaining longitudinal follow-up data (neuroimaging, cognitive testing, and blood) using a standardized protocol from a well characterized cohort of over 1,000 healthy individuals to generate within-participant brain trajectories for up to 10 years. At initial recruitment, individuals enrolled in the HCP-A were generally physically and cognitively healthy but over time some will develop preclinical AD or early cognitive changes due to AD or ADRD. The AABC is comprised of four Projects: Project 1 examine the effects of stress and allostatic load, including inflammation, during the early adult period. Project 2 examines the effects of lifestyle behaviors on the trajectory of cognitive and brain changes during the mid adult period. Project 3 examine the effects of menopause transition/vasomotor symptoms during the mid adult period. Project 4 exam- ine the clinical and neural indicators of resiliency and resistance to AD and ADRD in the later decades of adult- hood. The AABC also consists of 4 Cores: The Administration Core (AC) will provide essential core and site leadership to carry out the scientific mission of the AABC. The diversity recruitment and retention unit (DRRU) will be located within this core and will ensure that the AABC continues to recruit and retain an adequate distri- bution of races that is currently seen in the US. The Integrated Data Acquisition Core (IDAC) provides expertise and personnel from each site to acquire high quality neuroimaging, deep phenotyping of non-imaging data, and biosamples from each site.The Informatics, Data Analysis, and Statistics Core (IDASC) will house project imag- ing data using the IntraDB database, will perform quality control of raw and analyzed data, will develop and run cross-sectional and longitudinal pipelines to produce multi-modal imaging data phenotypes for each project, will provide dimension-reduced summaries, will impute missing data; and will develop and run statistical models for each project. The IDASC will also be responsible for data sharing with the general public. The Genetics and Multi-omics Specimens Core (GMSC) will provide genetic information on participants evaluated through the AABC who have been characterized using a uniform protocol. Multi-omic data and AD biomarker data will be generated by the GMSC.

摘要概述