Cannabis, HIV and Mental Processing Systems (CHAMPS)

摘要/项目摘要 这项提案使用新的方法来确定并发艾滋病毒的关键决定因素和后果 感染和经常使用大麻。我们将从外周和脑中获取广泛的表型数据 活着的人的免疫激活、脑结构和神经心理功能(NP)的标志 艾滋病毒(PLWH)接受联合抗逆转录病毒疗法(CART)(80名普通大麻使用者和80名 非吸毒者)和未感染艾滋病毒(艾滋病毒)对照(80个普通吸食大麻者和80个不吸食者)。我们的整体 假说是，大麻的使用会导致外周和脑室炎症的增加。 我们还假设，由于经常使用大麻和艾滋病毒而产生的表型特征将通过 NP和脑体积计量学。在目标1中，我们假设常规大麻使用将增加外周和 CART中PLWH患者的脑免疫指标。在目标2中，我们假设经常使用大麻将导致 在服用CART和HIV对照组的PLWH患者中，NP恶化和脑体积减少。这项建议 将提供对常规大麻和艾滋病毒对外周和大脑标志物的影响的关键见解 PLWH和HIV对照的免疫功能和NP水平。这些见解对于治愈策略和 正在进行的艾滋病毒治疗倡议。

ABSTRACT/PROJECT SUMMARY This proposal employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. We will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). Our overall hypothesis is that cannabis use leads to increases in inflammation in the peripheral and brain compartments. We also hypothesize that phenotypic signatures due to regular cannabis use and HIV will be delineated through NP and brain volumetrics. In Aim 1 we hypothesize that regular cannabis use will increase both peripheral and brain immune indices in PLWH on cART. In Aim 2 we hypothesize that regular cannabis use will lead to a worsening of NP and reductions in brain volumetrics in both PLWH on cART and HIV- controls. This proposal will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.