Reproducible imaging-based brain growth charts for psychiatry

用于精神病学的可重复的基于成像的大脑生长图

基本信息

  • 批准号:
    10626901
  • 负责人:
  • 金额:
    $ 65.56万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-08-22 至 2025-05-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT Major psychiatric illnesses are increasingly understood as disorders of brain development, which has led to large-scale studies of youth that combine multi-modal neuroimaging with clinical phenotyping. Together, such data have emphasized the promise of objective ‘growth charts’ of brain development. However, synergies across major efforts remains unrealized due to use of different clinical instruments, different scanning protocols, challenges in informatics, and difficulties in data integration. In this proposal, we will overcome these obstacles by leveraging advances in multivariate harmonization and analysis techniques to build highly reproducible growth charts of human brain development. To do this, we will aggregate and harmonize eight existing large-scale developmental imaging studies, comprising over 10,000 participants between the age of 5- 24 (Aim 1). We will use this harmonized data to build generalizable indices of normal network brain development (Aim 2). Finally, developmental abnormalities within specific brain networks will be linked to dimensions of psychopathology (Aim 3). Critically, all code, data, and derived indices will be shared publicly, creating a massive new resource to accelerate research in the developmental neuroscience community (Aim 4). In sum, this proposal will have provide a new data resource, yield reproducible growth charts of brain development, and delineate novel mechanisms regarding the developmental basis of psychopathology in youth.
摘要 主要的精神疾病越来越被理解为大脑发育障碍,这导致了 联合收割机多模态神经成像与临床表型相结合的大规模青年研究。一起的 数据强调了大脑发育的客观“生长图”的前景。然而,协同作用 由于使用了不同的临床仪器、不同的扫描方法, 协议,信息学的挑战和数据集成的困难。在这份提案中,我们将克服 利用多元协调和分析技术的进步, 人类大脑发育的可重复增长图表。为了做到这一点,我们将汇总和协调八个 现有的大规模发育成像研究,包括超过10,000名5岁至 24(目标1)。我们将使用这些协调的数据来建立正常网络脑的可推广指标 发展(目标2)。最后,特定大脑网络中的发育异常将与 精神病理学的维度(目标3)。重要的是,所有代码、数据和派生索引都将公开共享, 创建一个巨大的新资源,以加速发展神经科学界的研究(Aim 4)。总之,该方案将提供一种新的数据源,产生可重复的脑生长图 发展,并描绘新的机制,关于发展的基础上,精神病理学, 青年

项目成果

期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Eliminating accidental deviations to minimize generalization error and maximize replicability: Applications in connectomics and genomics.
  • DOI:
    10.1371/journal.pcbi.1009279
  • 发表时间:
    2021-09
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Bridgeford EW;Wang S;Wang Z;Xu T;Craddock C;Dey J;Kiar G;Gray-Roncal W;Colantuoni C;Douville C;Noble S;Priebe CE;Caffo B;Milham M;Zuo XN;Consortium for Reliability and Reproducibility;Vogelstein JT
  • 通讯作者:
    Vogelstein JT
Screen time and psychopathology: investigating directionality using cross-lagged panel models.
  • DOI:
    10.1007/s00787-020-01675-5
  • 发表时间:
    2022-04
  • 期刊:
  • 影响因子:
    6.4
  • 作者:
    Bado P;Schafer J;Simioni AR;Bressan RA;Gadelha A;Pan PM;Miguel EC;Rohde LA;Salum GA
  • 通讯作者:
    Salum GA
Comparing mental health semi-structured diagnostic interviews and symptom checklists to predict poor life outcomes: an 8-year cohort study from childhood to young adulthood in Brazil.
  • DOI:
    10.1016/s2214-109x(23)00462-x
  • 发表时间:
    2024-01
  • 期刊:
  • 影响因子:
    34.3
  • 作者:
    Hoffmann, Mauricio Scopel;Pine, Daniel S.;Georgiades, Katholiki;Szatmari, Peter;Miguel, Euripedes Constantino;Pan, Pedro Mario;Gadelha, Ary;Rohde, Luis Augusto;Merikangas, Kathleen Ries;Milham, Michael Peter;Satterthwaite, Theodore Daniel;Salum, Giovanni Abrahao
  • 通讯作者:
    Salum, Giovanni Abrahao
Parent- and teacher-reported associations from adolescent bifactor models of psychopathology: an outcome-wide association study of 26 outcomes in mid-life.
家长和老师报告的青少年精神病理学双因素模型中的关联:对中年 26 种结果的全结果关联研究。
Reliability and validity of bifactor models of dimensional psychopathology in youth.
  • DOI:
    10.1037/abn0000749
  • 发表时间:
    2022-05
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Scopel Hoffmann, Mauricio;Moore, Tyler Maxwell;Kvitko Axelrud, Luiza;Tottenham, Nim;Zuo, Xi-Nian;Rohde, Luis Augusto;Milham, Michael Peter;Satterthwaite, Theodore Daniel;Salum, Giovanni Abrahao
  • 通讯作者:
    Salum, Giovanni Abrahao
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Michael Peter Milham其他文献

Clinical decision support systems in child and adolescent psychiatry: a systematic review
儿童和青少年精神病学中的临床决策支持系统:系统评价
  • DOI:
    10.1007/s00787-017-0992-0
  • 发表时间:
    2017-04-28
  • 期刊:
  • 影响因子:
    4.900
  • 作者:
    Roman Koposov;Sturla Fossum;Thomas Frodl;Øystein Nytrø;Bennett Leventhal;Andre Sourander;Silvana Quaglini;Massimo Molteni;María de la Iglesia Vayá;Hans-Ulrich Prokosch;Nicola Barbarini;Michael Peter Milham;Francisco Xavier Castellanos;Norbert Skokauskas
  • 通讯作者:
    Norbert Skokauskas

Michael Peter Milham的其他文献

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{{ truncateString('Michael Peter Milham', 18)}}的其他基金

Reproducible imaging-based brain growth charts for psychiatry
用于精神病学的可重复的基于成像的大脑生长图
  • 批准号:
    9810689
  • 财政年份:
    2019
  • 资助金额:
    $ 65.56万
  • 项目类别:
Reproducible imaging-based brain growth charts for psychiatry
用于精神病学的可重复的基于成像的大脑生长图
  • 批准号:
    10001025
  • 财政年份:
    2019
  • 资助金额:
    $ 65.56万
  • 项目类别:
Reproducible imaging-based brain growth charts for psychiatry
用于精神病学的可重复的基于成像的大脑生长图
  • 批准号:
    10430126
  • 财政年份:
    2019
  • 资助金额:
    $ 65.56万
  • 项目类别:
Reproducible imaging-based brain growth charts for psychiatry
用于精神病学的可重复的基于成像的大脑生长图
  • 批准号:
    10175049
  • 财政年份:
    2019
  • 资助金额:
    $ 65.56万
  • 项目类别:
Neurobiology and Cognitive Role of Slow Brain Network Fluctuations
神经生物学和慢脑网络波动的认知作用
  • 批准号:
    10639542
  • 财政年份:
    2017
  • 资助金额:
    $ 65.56万
  • 项目类别:
Macroscale physiology and functional correlates of slow network fluctuations
缓慢网络波动的宏观生理学和功能相关性
  • 批准号:
    10639544
  • 财政年份:
    2017
  • 资助金额:
    $ 65.56万
  • 项目类别:
Neuroimaging Core
神经影像核心
  • 批准号:
    10175039
  • 财政年份:
    2017
  • 资助金额:
    $ 65.56万
  • 项目类别:
Defining Neuronal Circuits and Cellular Processes Underlying Resting fMRI Signals
定义静息 fMRI 信号下的神经元回路和细胞过程
  • 批准号:
    9206010
  • 财政年份:
    2016
  • 资助金额:
    $ 65.56万
  • 项目类别:
Longitudinal Discovery of Brain Developmental Trajectories
大脑发育轨迹的纵向发现
  • 批准号:
    9303454
  • 财政年份:
    2013
  • 资助金额:
    $ 65.56万
  • 项目类别:
Longitudinal Discovery of Brain Developmental Trajectories
大脑发育轨迹的纵向发现
  • 批准号:
    9085391
  • 财政年份:
    2013
  • 资助金额:
    $ 65.56万
  • 项目类别:

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