Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)

衰老和跨学科神经科学的简要研究（BRAIN）

• 批准号: 10628895
• 负责人: Sachin Agarwal
• 金额: $ 18.05万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628895
• 关键词: Academic Medical Centers; Aging; Alzheimer' s disease related dementia; Authorship; Basic Science; Behavioral Research; Biomedical Research; Clinical Research; Clinical Trials; Disease; Educational Curriculum; Epidemiology; Epilepsy; Funding; Institution; Mentors; Motor Neuron Disease; Nervous System; Neurologic; Neurologist; Neurology; Neuropsychology; Neurosciences; Parkinson Disease; Patients; Positioning Attribute; Reproducibility; Research; Research Methodology; Research Project Grants; Research Training; Resources; Site; Stroke; Structure; Students; Work; career; collaborative approach; doctoral student; education research; experience; multidisciplinary; nervous system disorder; neurogenetics; neuropathology; posters; pre-clinical; pre-doctoral; programs; responsible research conduct; student participation; summer research

Project summary The Department of Neurology at Columbia University Medical Center serves as a rich site for multidisciplinary neurological research, with particular focus on disorders associated with the aging nervous system. This proposal seeks to continue funding for positions for 25 preclinical students participating in the Brief Research in Aging and Interdisciplinary Neurosciences (BRAIN) program each summer. For the BRAIN program, we have developed a comprehensive approach to develop a formal research program for predoctoral students early in developing careers in biomedical, behavioral and clinical research. The work is collaboratively approached through brief but intensive mentored summer research training experiences for these students. The research training provides opportunities in basic, behavioral and clinical research through ongoing research in the fields of basic neuroscience, neuropathology, neurogenetics, neuropsychology, stroke, Alzheimer disease and related disorders, motor neuron disease, Parkinson disease and related disorders, and epilepsy, as well as neurologic clinical trials treating patients with these disorders. In addition, a comprehensive structured research education curriculum is delivered over the course of the intense research experience, with topics including responsible conduct of research and methods to enhance reproducibility, basic research methodologies, introductions to abstract authorship and poster presentations, and introduction of statistical concepts and approach to analyses, as well as epidemiologic and pathophysiologic reviews of the most common neurologic disorders associated with aging and thus likely to be studied. Our institution has the strongest track record of developing academic neurologists of anywhere worldwide, and this short-term, intense program builds upon this wealth of resources through hands-on introductions to neurological research, comprehensive review of principles of research, and thus assures the best opportunity for these students to develop research careers in the field and be prepared to developing research projects of their own.

项目摘要 哥伦比亚大学医学中心的神经病学系是多学科的丰富网站， 神经学研究，特别关注与衰老神经系统相关的疾病。这 该提案旨在继续资助25名临床前学生参加简短的研究， 老化和跨学科神经科学（大脑）计划每年夏天。对于大脑计划，我们有 制定了一个全面的方法来制定一个正式的研究计划，为博士生早在 在生物医学、行为学和临床研究方面发展事业。这项工作是以协作的方式进行的 通过为这些学生提供简短但密集的暑期研究培训经验。研究 培训提供了基础，行为和临床研究的机会，通过正在进行的研究领域， 基础神经科学，神经病理学，神经遗传学，神经心理学，中风，阿尔茨海默病和 相关病症、运动神经元疾病、帕金森病和相关病症和癫痫，以及 治疗这些疾病患者的神经病学临床试验。此外，一个全面的结构化研究 教育课程是在密集的研究经验的过程中交付，与主题包括 负责任的研究和方法，以提高再现性，基本的研究方法， 介绍摘要作者和海报演示，并介绍统计概念和 分析方法，以及最常见的神经系统疾病的流行病学和病理生理学综述 与衰老相关的疾病，因此可能被研究。我们的机构拥有最强的跟踪记录， 培养世界各地的学术神经学家，这个短期的，紧张的计划建立在 这丰富的资源，通过动手介绍神经学研究，全面审查 研究的原则，从而确保这些学生发展研究事业的最佳机会， 并准备开发自己的研究项目。

项目成果

Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.

• DOI: 10.1016/j.phrs.2018.03.020
• 发表时间: 2018-06
• 期刊: Pharmacological research
• 影响因子: 9.3
• 作者: Israelyan N;Margolis KG
• 通讯作者: Margolis KG

Association of leisure-time physical activity and sedentary behavior with carotid atherosclerosis morphology: The ARIC carotid-MRI study.

休闲时间的体育锻炼与久坐行为与颈动脉粥样硬化形态的关联：Aric Carotid-MRI研究。

• DOI: 10.1016/j.ajpc.2023.100505
• 发表时间: 2023-06
• 期刊: AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
• 影响因子: 4.1
• 作者: Kumar, Aarti;Qiao, Ye;Wasserman, Bruce;Gabriel, Kelley Pettee;Martinez-Amezcua, Pablo;Dooley, Erin E;Diaz, Keith M;Evenson, Kelly R;Sharrett, A Richey;Zhang, Yiyi;Palta, Priya
• 通讯作者: Palta, Priya

Surgical site infections in pediatric spinal surgery after implementation of a quality assurance program.

实施质量保证计划后小儿脊柱手术的手术部位感染。

• DOI: 10.1007/s43390-020-00192-4
• 发表时间: 2021
• 期刊: Spine deformity
• 影响因子: 1.6
• 作者: Hammoor,Bradley;Matsumoto,Hiroko;Marciano,Gerard;Dziesinski,Lucas;Wang,Kevin;Roye,BenjaminD;Roye,DavidP;Vitale,MichaelG
• 通讯作者: Vitale,MichaelG

Impact of Panel Gene Testing for Hereditary Breast and Ovarian Cancer on Patients.

面板基因测试对遗传性乳腺癌和卵巢癌对患者的影响。

• DOI: 10.1007/s10897-017-0090-y
• 发表时间: 2017-10
• 期刊: Journal of genetic counseling
• 影响因子: 1.9
• 作者: Lumish HS;Steinfeld H;Koval C;Russo D;Levinson E;Wynn J;Duong J;Chung WK
• 通讯作者: Chung WK

Longitudinal Tracking of Sound Exposure and Hearing Aid Usage through Objective Data Logs.

• DOI: 10.1177/0194599818766056
• 发表时间: 2018-07
• 期刊: Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
• 作者: Doyle JB;Raghunathan RR;Cellum I;Li G;Golub JS
• 通讯作者: Golub JS