NR1F (ROR) nuclear hormone receptors and metabolism: insights into the control of lipid homeostasis.

NR1F (ROR) 核激素受体和代谢：对脂质稳态控制的见解。

• 批准号: nhmrc : 569741
• 负责人: Prof George Muscat
• 金额: $ 38.8万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nr1f-ror-nuclear-lipid-homeostasis/100662
• 关键词: NR1F; ROR; nuclear; hormone; receptors

ROR is a member of a gene family, that regulates reproduction, endocrine physiology, and metabolism, and are important in human health. ROR function remains illusive. However, it is expressed in liver, fat and muscle, tissues that (i) modulate blood lipids, insulin sensitivity and energy balance, and (ii) have an important role in diabetes and obesity. Understanding ROR function in metabolism provides the opportunity for the discovery of new pathways that ameliorate metabolic disease.

ROR是调节生殖、内分泌生理和代谢的基因家族的成员，并且对人类健康很重要。ROR功能仍然是虚幻的。然而，它在肝脏、脂肪和肌肉组织中表达，这些组织（i）调节血脂、胰岛素敏感性和能量平衡，以及（ii）在糖尿病和肥胖症中具有重要作用。了解ROR在代谢中的功能为发现改善代谢疾病的新途径提供了机会。