Nuclear Receptor 4A3 signalling in skeletal muscle

骨骼肌中的核受体 4A3 信号传导

• 批准号: nhmrc : 631480
• 负责人: Prof George Muscat
• 金额: $ 31.72万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nuclear-receptor-4a3-skeletal-muscle/97147
• 关键词: Nuclear; Receptor; 4A3; signalling; skeletal

Nuclear receptors regulate hormonal control of reproduction, endocrine physiology, and metabolism, and are very important in human health. NR4A3 function in peripheral tissues remains illusive. However, it is expressed in skeletal muscle, a tissue that (i) modulates blood lipids, insulin sensitivity and energy balance, and (ii) has an imortant role in diabetes and obesity. Understanding NR4A3 function in metabolism provides a potential platform for therapeutic intervention.

核受体调节生殖、内分泌生理和代谢的激素控制，并且在人类健康中非常重要。NR4A3在外周组织中的功能仍然是虚幻的。然而，它在骨骼肌中表达，骨骼肌是一种（i）调节血脂、胰岛素敏感性和能量平衡，以及（ii）在糖尿病和肥胖症中具有重要作用的组织。了解NR4A3在代谢中的功能为治疗干预提供了一个潜在的平台。