Endocrine control of metabolic disease

代谢性疾病的内分泌控制

• 批准号: nhmrc : 1059341
• 负责人: Prof George Muscat
• 金额: $ 50.9万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/endocrine-control-metabolic-disease/454750
• 关键词: Endocrine; control; metabolic; disease

The nuclear hormone receptors (NRs) translate hormonal, metabolic & pathophysiological signals into gene regulation, and several NRs are very important in human health. NRs are important therapeutics targets in the treatment of dyslipidemia, insulin insensitivity and breast cancer. Our data identifies new and novel NR targets that can be therapeutically/pharmacologically exploited in the context of exercise capacity, metabolic disease and breast cancer.

核激素受体（nuclear hormone receptors，NRs）是将激素、代谢和病理生理信号转化为基因调控的重要受体，其中一些受体在人类健康中起着重要作用。核受体是治疗血脂异常、胰岛素不敏感和乳腺癌的重要靶点。我们的数据确定了新的和新颖的NR靶点，这些靶点可以在运动能力、代谢疾病和乳腺癌的背景下进行治疗/开发。