Understanding the physiological role of COUP-TF orphan nuclear receptors in skeletal muscle.

了解 COUP-TF 孤儿核受体在骨骼肌中的生理作用。

• 批准号: nhmrc : 569742
• 负责人: Prof George Muscat
• 金额: $ 30.33万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-physiological-role-skeletal-muscle/76229
• 关键词: Understanding; physiological; role; COUP; TF

COUP-TF is a protein expressed in skeletal muscle, a tissue that accounts for ~40% of the body mass and energy expenditure, and is a major site of nutrient metabolism. COUP-TF is a member of the nuclear hormone receptor (NR) superfamily. These proteins respond to physiological signals, and are targets of pharmaceuticals for the treatment of inflammation, metabolic and endorcrine disorders. Our project is directed toward understanding the role of COUP-TF in the context of metabolism and obesity.

COUP-TF是一种在骨骼肌中表达的蛋白质，骨骼肌占身体质量和能量消耗的40%左右，是营养代谢的主要部位。COUP-TF是核激素受体（NR）超家族的成员。这些蛋白质对生理信号作出反应，是治疗炎症、代谢和内分泌紊乱的药物的靶点。我们的项目旨在了解COUP-TF在新陈代谢和肥胖中的作用。