Retinoic acid receptor-related orphan receptors and the regulation of metabolism:insights into diabetes and obesity

视黄酸受体相关的孤儿受体和代谢调节：对糖尿病和肥胖的见解

• 批准号: nhmrc : 1027484
• 负责人: Prof George Muscat
• 金额: $ 50.73万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/retinoic-acid-receptor-diabetes-obesity/110572
• 关键词: Retinoic; acid; receptor; related; orphan

Nuclear receptors (NRs) function as hormone dependent DNA binding proteins important in sustaining human health, highlighted by the array of medicines that target these proteins for human well being. ROR alpha is one such protein that we have shown regulates fat mass, obesity, and glucose tolerance. Obesity and diabetes are often linked with inflammation. We will examine how ROR controls inflammation during metabolic disease.

核受体（NR）作为激素依赖性DNA结合蛋白在维持人类健康方面发挥重要作用，这一点通过靶向这些蛋白质以促进人类健康的一系列药物来强调。ROR α就是这样一种蛋白质，我们已经证明它可以调节脂肪量、肥胖和葡萄糖耐量。肥胖和糖尿病通常与炎症有关。我们将研究ROR如何控制代谢疾病期间的炎症。