Environment, Epigenetics, Neurodevelopment & Health of Extremely Preterm Children

项目摘要/摘要 环境对儿童健康结局影响第二阶段(2023-2030)的目标(ECHO) 该计划是扩大和扩大ECHO队列，以进一步调查广泛的早期影响 在怀孕期和成年后的社会和生物暴露，关于Echo的五个 在不同人群中的关键儿童健康结果。我们的儿科Echo队列Elgan-Echo建议 继续：(1)领导协作回声队列科学，(2)跟踪现有回声队列参与者， (3)实现了回声队列数据和生物样本收集协议。这个项目的总体目标是 建议是：(1)评估暴露于环境应激源(化学和非化学)的预测因素 在未孕、怀孕和儿童早期；(2)确定有可能改变 环境暴露、围产期炎症生物标志物(例如，表观遗传， 基因组和蛋白质组)和神经发育结果作为我们建议的专业成果领域；以及(3) 最大限度地留住不同的埃尔根学员。我们将带来环境方面的专业知识 与金属、胎盘表观遗传学、早产的前因和相关因素有关的流行病学，以及 所提议的项目的神经发育结果。在项目的头两年(UG3阶段) ECHO-ELGAN团队的调查人员将与ECHO计划合作 为预想时期和数据协调制定回声队列议定书；牵头和 参与回声委员会、工作组和特别工作组；计划参与者跟进，获得批准 在回声队列联盟的单一IRB的监督下执行回声队列协议； 重新同意现有的回声队列参与者；执行回声队列协议以收集数据和 该协议中指定的生物样本；使用中央数据捕获系统来填充回声队列 数据平台；留住研究参与者，重点放在不同的人群；并制作和 通过出版物和其他公开演讲传播Echo Cohort科学。在接下来的五年中 年(UH3阶段)我们将扩大ECHCOROT科学的开发、生产和传播， 并继续在保持高保留率和对回声队列协议的保真度方面提供专业知识。 我们的总体视角将是面向解决方案的研究问题，这些问题将利用 回声队列的样本大小、多样性和纵向性质，并有可能影响实践， 改善儿童健康的方案和政策。

PROJECT SUMMARY/ABSTRACT The goal of the second phase (2023-2030) of the Environmental influences on Child Health Outcomes (ECHO) Program is to extend and expand the ECHO Cohort to further investigate the impact of a broad range of early social and biological exposures during the preconception period and into young adulthood, on ECHO’s five key child health outcomes among diverse populations. Our pediatric ECHO cohort, ELGAN-ECHO, proposes to continue to: (1) lead collaborative ECHO Cohort science, (2) follow up existing ECHO Cohort participants, and (3) implement the ECHO Cohort Data and Biospecimen Collection Protocol. The broad goals of this proposal are to: (1) evaluate predictors of exposure to environmental stressors (chemical and non-chemical) during preconception, pregnancy, and early childhood; (2) identify factors that have the potential to modify the relationships between environmental exposures, perinatal biomarkers of inflammation (e.g., epigenetic, genomic and proteomic) and neurodevelopmental outcomes as our proposed specialty outcome area; and (3) maximize retention of diverse ELGAN participants. We will bring specialized expertise in environmental epidemiology related to metals, placental epigenetics, antecedents and correlates of preterm birth, and neurodevelopmental outcomes to the proposed project. In the first two years of the project (the UG3 phase) investigators from the ECHO-ELGAN team will collaborate with the ECHO Program to collaborate on the development of the ECHO Cohort Protocol for the preconception period and harmonization of data; lead and participate on ECHO committees, working groups, and task forces; plan participant follow-up, obtain approval for conducting the ECHO Cohort Protocol with oversight from the ECHO Cohort Consortium’s single IRB; reconsent existing ECHO Cohort participants; implement the ECHO Cohort Protocol for collection of data and biospecimens specified in that protocol; use the central data capture system to populate the ECHO Cohort Data Platform; retain study participants with an emphasis on diverse populations; and produce and disseminate ECHO Cohort science through publications and other public presentations. In the following five years (the UH3 phase) we will expand development, production, and dissemination of ECHO Cohort science, and continue to lend expertise on maintaining high retention rates and fidelity to the ECHO Cohort Protocol. Our over-arching perspective will be solution-oriented research questions that take advantage of the large sample size, diversity, and longitudinal nature of the ECHO Cohort and have potential to influence practices, programs, and policies to improve children’s health.