Precancer Atlas of Familial Adenomatous Polyposis

家族性腺瘤性息肉病癌前图谱

基本信息

  • 批准号:
    10900834
  • 负责人:
  • 金额:
    $ 97.09万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2023
  • 资助国家:
    美国
  • 起止时间:
    2023-04-04 至 2024-08-31
  • 项目状态:
    已结题

项目摘要

Colorectal cancer (CRC) is the third highest cause of cancer death in the United States. Almost 80% of sporadic colorectal cancers have an APC gene mutation. Familial adenomatous polyposis (FAP), a hereditary colon cancer syndrome, is also caused by mutations in APC and affects children as young as 7 years of age. FAP causes hundreds of colonic polyps in affected individuals and a 100% lifetime risk of CRC. In preliminary efforts we have successfully collected hundreds of pre-cancerous colon polyps from individual FAP patients, applied genomic, epigenomic and other multi-omic analyses and begun to elucidate the impact of multiple types of “omic” alterations on precancerous colon polyp evolution toward CRC. We propose to use an integrated and collaborative approach to develop a PreCancer Atlas for colorectal adenocarcinoma using FAP as the disease model. We will: 1) Establish a biospecimen collection pipeline for procurement of longitudinal tissue samples during surveillance colonoscopy and during prophylactic surgical colectomy, including whole blood, serum, normal colonic tissue, colon microbiome, benign pre-cancerous polyps, dysplastic precancerous polyps and colon adenocarcinomas. The material will be used for our own center and will also be available to the Human Tumor Atlas Network (HTAN). Medical records, longitudinal samples and all relevant metadata will also be collected. 2) Establish a center to characterize the tissue samples with state-of-the-art omics and imaging technologies. These include but are not limited to whole genome sequencing, methylation, transcriptome, proteome, cytokine, metabolome, microbiome, and molecular imaging. 3) Establish an analysis core that analyzes and integrates results from -omics, imaging and medical information, builds a spatiotemporal, multidimensional, integrative multi-omics cancer atlas, and develops longitudinal and predictive models for PreCancer biology and progression, as well as data portal and visualization framework. 4) Establish multi-omics technologies on smaller number of samples. 5) Perform a “multiscale deep data analysis” on a large number of samples (57) from a few people and a fewer number of samples (6) from many people. Use this information to guide additional data collection. 6) Identify factors (e.g. germline genetics, microbiome, immune dysfunction) contributing to polyp heterogeneity between and across individuals. Build disease progression models based on these data. 7) Make all biospecimens, information, protocols and software available to the PCA, HTAN and the general scientific community. We expect our efforts will greatly facilitate understanding CRC at its earliest stages and serve as a model for understanding precancerous lesions of other solid tumor malignancies.
结直肠癌(CRC)是美国癌症死亡的第三大原因。几乎80%

项目成果

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MICHAEL P. SNYDER其他文献

MICHAEL P. SNYDER的其他文献

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{{ truncateString('MICHAEL P. SNYDER', 18)}}的其他基金

Organ Specific Project
器官特定项目
  • 批准号:
    10709580
  • 财政年份:
    2022
  • 资助金额:
    $ 97.09万
  • 项目类别:
Organ Specific Project
器官特定项目
  • 批准号:
    10531083
  • 财政年份:
    2022
  • 资助金额:
    $ 97.09万
  • 项目类别:
PRODUCTION CENTER FOR MAPPING REGULATORY REGIONS OF THE HUMAN GENOME
人类基因组监管区域图谱制作中心
  • 批准号:
    10241080
  • 财政年份:
    2021
  • 资助金额:
    $ 97.09万
  • 项目类别:
The Chromium Connect, an integrated and robotic system to automate library preparation for single-cell RNA-Seq
Chromium Connect,一个集成的机器人系统,用于自动进行单细胞 RNA 测序的文库制备
  • 批准号:
    10171302
  • 财政年份:
    2021
  • 资助金额:
    $ 97.09万
  • 项目类别:
Identifying Multidimensional Omics Profiles Associated with Cardiovascular and Pulmonary Responses to Chronic and Acute Air Pollution Exposure (Project 2) for AIRHEALTH Study
确定与慢性和急性空气污染暴露的心血管和肺部反应相关的多维组学概况(项目 2),用于空气健康研究
  • 批准号:
    10460331
  • 财政年份:
    2021
  • 资助金额:
    $ 97.09万
  • 项目类别:
Identifying Multidimensional Omics Profiles Associated with Cardiovascular and Pulmonary Responses to Chronic and Acute Air Pollution Exposure (Project 2) for AIRHEALTH Study
确定与慢性和急性空气污染暴露的心血管和肺部反应相关的多维组学概况(项目 2),用于空气健康研究
  • 批准号:
    10269335
  • 财政年份:
    2021
  • 资助金额:
    $ 97.09万
  • 项目类别:
Multi-Modal Wireless COVID Monitoring & Infection Alerts for Concentrated Populations
多模式无线新冠肺炎监测
  • 批准号:
    10594946
  • 财政年份:
    2020
  • 资助金额:
    $ 97.09万
  • 项目类别:
Multi-Modal Wireless COVID Monitoring & Infection Alerts for Concentrated Populations
多模式无线新冠肺炎监测
  • 批准号:
    10320756
  • 财政年份:
    2020
  • 资助金额:
    $ 97.09万
  • 项目类别:
Multi-Modal Wireless COVID Monitoring & Infection Alerts for Concentrated Populations
多模式无线新冠肺炎监测
  • 批准号:
    10274232
  • 财政年份:
    2020
  • 资助金额:
    $ 97.09万
  • 项目类别:
Genomics Diversity Summer Program (GDSP) at Stanford
斯坦福大学基因组多样性暑期项目 (GDSP)
  • 批准号:
    10408049
  • 财政年份:
    2019
  • 资助金额:
    $ 97.09万
  • 项目类别:

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Elucidation of the function of Apc gene in the formation of hippocampal neural networks using a novel three-dimensional analysis method
使用新颖的三维分析方法阐明 Apc 基因在海马神经网络形成中的功能
  • 批准号:
    18K14843
  • 财政年份:
    2018
  • 资助金额:
    $ 97.09万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Microencapsulated carbon nanotube-gene devices for targeted delivery of wild type apc gene in the treatment of colorectal adenocarcinoma.
用于靶向递送野生型 apc 基因治疗结直肠腺癌的微囊碳纳米管基因装置。
  • 批准号:
    348688-2007
  • 财政年份:
    2008
  • 资助金额:
    $ 97.09万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Microencapsulated carbon nanotube-gene devices for targeted delivery of wild type apc gene in the treatment of colorectal adenocarcinoma.
用于靶向递送野生型 apc 基因治疗结直肠腺癌的微囊碳纳米管基因装置。
  • 批准号:
    348688-2007
  • 财政年份:
    2007
  • 资助金额:
    $ 97.09万
  • 项目类别:
    Alexander Graham Bell Canada Graduate Scholarships - Doctoral
Rapid Assay for the l1307K Mutation of the APC Gene
APC 基因 l1307K 突变的快速检测
  • 批准号:
    6654369
  • 财政年份:
    2000
  • 资助金额:
    $ 97.09万
  • 项目类别:
INHIBITION OF COLONIC TUMORS IN MICE CARRYING A TRUNCATED APC GENE
携带截短的 APC 基因的小鼠中结肠肿瘤的抑制
  • 批准号:
    6300216
  • 财政年份:
    2000
  • 资助金额:
    $ 97.09万
  • 项目类别:
Rapid Assay for the l1307K Mutation of the APC Gene
APC 基因 l1307K 突变的快速检测
  • 批准号:
    6549455
  • 财政年份:
    2000
  • 资助金额:
    $ 97.09万
  • 项目类别:
RAPID ASSAY FOR THE I1307K MUTATION OF THE APC GENE
APC 基因 I1307K 突变的快速检测
  • 批准号:
    6074583
  • 财政年份:
    2000
  • 资助金额:
    $ 97.09万
  • 项目类别:
INHIBITION OF COLONIC TUMORS IN MICE CARRYING A TRUNCATED APC GENE
携带截短的 APC 基因的小鼠中结肠肿瘤的抑制
  • 批准号:
    6102062
  • 财政年份:
    1999
  • 资助金额:
    $ 97.09万
  • 项目类别:
INHIBITION OF COLONIC TUMORS IN MICE CARRYING A TRUNCATED APC GENE
携带截短的 APC 基因的小鼠中结肠肿瘤的抑制
  • 批准号:
    6269116
  • 财政年份:
    1998
  • 资助金额:
    $ 97.09万
  • 项目类别:
EPITHELIAL HOMEOSTASIS IN APC GENE MUTATION
APC 基因突变中的上皮稳态
  • 批准号:
    6173165
  • 财政年份:
    1997
  • 资助金额:
    $ 97.09万
  • 项目类别:
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