2-Generation Interventions to Improve Cardiovascular Health in Indiana and Illinois Through Home Visiting (2-NOURISH)
通过家访改善印第安纳州和伊利诺伊州心血管健康的第二代干预措施 (2-NOURISH)
基本信息
- 批准号:10622594
- 负责人:
- 金额:$ 81.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-16 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:3 year old5 year oldAddressAdoptionAgeAmerican Heart AssociationBehavior TherapyBirthBody mass indexCardiovascular DiseasesCause of DeathChildChildhoodClinical Trials DesignCognitive TherapyCollaborationsCommunitiesDataDevelopmentDisparityEarly InterventionEffectivenessEligibility DeterminationEnrollmentEnsureEquityEthnic OriginEvidence based interventionFamilyGenerationsGeographyGoalsHealthHealth PolicyHealth PromotionHealth behaviorHigh PrevalenceHomeHome visitationIllinoisImpaired cognitionImplementation readinessIndianaIndividualInternationalInterventionIntervention StudiesLife Cycle StagesLinkMaintenanceMaternal MortalityMaternal and Child HealthMeasuresMental DepressionMental HealthMissionModelingMonitorMothersNational Heart, Lung, and Blood InstituteNetwork-basedObesityOutcomeOverweightParentsParticipantPerinatalPhasePopulationPopulation HeterogeneityPopulations at RiskPositioning AttributePostpartum PeriodPregnancyProtocols documentationPsychosocial FactorQualifyingRaceRandomizedRandomized, Controlled TrialsReach, Effectiveness, Adoption, Implementation, and MaintenanceResearch DesignResearch PersonnelResourcesRiskScienceServicesSocietiesSocioeconomic StatusTechniquesTestingTimeUnited StatesUnited States Preventative Services Task ForceWeightWorkcardiovascular disorder riskcardiovascular healthclinical centerclinical research siteclinically relevantcluster randomized designcostdisabilityearly childhoodeffectiveness evaluationeffectiveness testingeffectiveness/implementation hybridevidence baseexperiencehealth assessmenthealth disparityhealth of the motherhealthy weightimplementation evaluationimplementation outcomesimplementation scienceimprovedin uteroinnovationintergenerationalintervention participantslifestyle interventionmaternal morbiditymulti-component interventionmultidisciplinarymultiple chronic conditionsoffspringpatient navigationpeer supportperinatal periodperipartum depressionpilot testpregnantprenatalprogramspsychosocialrecruitresponsesexskillsstress managementsuccessteachertimelinetransmission processvirtual deliveryvirtual platformyoung adult
项目摘要
PROJECT SUMMARY
This application proposing the 2-GeneratioN Interventions to ImprOve CardiovascUlaR Health in Indiana and
IllinoiS Through Home Visiting (2-NOURISH) is in response to the RFA “Early Intervention to Promote
Cardiovascular Health of Mothers and Children (ENRICH) Multisite Clinical Center (RFA-HL-22-007)”. Given
growing rates of maternal morbidity and mortality, interventions to optimize maternal cardiovascular health
(CVH) are urgently needed. Poor maternal CVH is also associated with poor offspring CVH. As a result, the
perinatal period is an opportune time to intervene, but evidence-based interventions are limited. Home visiting
(HV) programs serve as an ideal setting to conduct intervention research aimed at improving maternal and
child CVH as they already serve an at-risk population across the United States with a high prevalence of poor
CVH. The proposed Clinical Center, 2-NOURISH, led by Northwestern, in partnership with two evidence-based
HV models (Healthy Families America [HFA] and Parents as Teachers [PAT]), and an evidence-based virtual
platform for lifestyle intervention, Weight Watchers International (WW), is uniquely qualified to participate in all
aspects of the ENRICH Network and to substantially enhance the Network’s goals. In our application, we
demonstrate key prior experiences, which include: (1) long-standing collaborations with HV models, including
MPI Tandon’s evidence-based perinatal depression and stress management intervention (Mothers and
Babies); (2) significant expertise in the development and assessment of maternal and child CVH, particularly
during the perinatal period; and (3) extensive experience with recruitment and retention of diverse populations
for behavior interventions. During the UG3 phase (Years 1-2), we will work collaboratively within the ENRICH
Network to develop a common study protocol, adapt the intervention content, and conduct pilot tests. During
the UH3 phase (Years 3-7), we will recruit 600 mother-child dyads in partnership with 40 HV programs in
Illinois and Indiana within the proposed study timeline to achieve the ENRICH Network Goal of 3000 total
dyads to examine the effectiveness of an implementation-ready, CVH-focused, evidence-based intervention.
We carefully considered potential study designs and propose a Hybrid Effectiveness-Implementation Type 1
trial with a cluster randomized design that would randomize at the home visitor-level. Additionally, given the
potential maternal and offspring benefits of intervention during pregnancy, we propose prenatal recruitment.
Our proposed intervention also includes innovative prenatal (promotion of stress management techniques,
home visitor patient navigation) and postpartum (intensive lifestyle intervention with a virtual delivery platform,
peer support) components. Our Clinical Center is additionally committed to developing the skills of Early Stage
Investigators related to clinical trial design and the skills of home visitors related to the construct of CVH, its
components, and the common study protocol. 2-NOURISH is ideally suited to serve as a Clinical Center and
contribute to the Network’s long-term mission to equitably improve maternal and early childhood CVH.
项目总结
这份申请提出了第二代干预措施,以改善印第安纳州和
伊利诺伊州通过家访(2-Nutiish)是为了回应RFA的“早期干预促进”
母婴心血管健康(RICH)多点临床中心(RFA-HL-22-007)“。vt.给出
孕产妇发病率和死亡率不断上升,优化孕产妇心血管健康的干预措施
(CVH)是迫切需要的。母体CVH差也与子代CVH差有关。因此,
围产期是干预的好时机,但循证干预是有限的。家访
(HV)方案是开展干预研究的理想环境,旨在改善孕产妇和
儿童CVH,因为他们已经为全美贫困患病率较高的高危人群提供服务
CVH。拟议的临床中心,2-Nutiish,由西北大学领导,与两个循证医学中心合作
HV模型(美国健康家庭[HFA]和家长当老师[PAT])和一个基于证据的虚拟
生活方式干预平台国际慧俪轻体(WW)是唯一有资格参与
加强该网络的方方面面,并大大加强该网络的目标。在我们的应用程序中,我们
展示以前的关键经验,包括:(1)与高压模型的长期合作,包括
MPI Tandon的循证围产期抑郁和压力管理干预(母亲和
(2)在母婴CVH的发展和评估方面具有重要的专门知识,特别是
在围产期;以及(3)在招募和留住不同人群方面有丰富的经验
进行行为干预。在UG3阶段(第1-2年),我们将在Enrich中进行协作
网络制定共同的研究方案,调整干预内容,并进行中试。在.期间
UH3阶段(3-7年级),我们将招募600名母婴双胞胎,与40个HV项目合作
伊利诺伊州和印第安纳州在拟议的研究时间表内实现丰富网络的目标,总数为3000
DUADS,检查实施就绪、以CVH为重点、以证据为基础的干预措施的有效性。
我们仔细考虑了潜在的研究设计,并提出了混合有效性-实施类型1
试验采用集群随机设计,将在家庭访客层面随机化。此外,鉴于
孕期干预对母子的潜在益处,我们建议产前招募。
我们建议的干预措施还包括创新的产前(推广压力管理技术,
家庭访客患者导航)和产后(利用虚拟递送平台进行密集的生活方式干预,
对等支持)组件。我们的临床中心还致力于发展早期技能
与临床试验设计相关的研究人员和与CVH、ITS结构相关的家庭访客的技能
组件和共同研究方案。2-Nutiish非常适合作为临床中心和
为该网络公平改善产妇和幼儿健康状况的长期使命作出贡献。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Matthew M Davis其他文献
Risk factors for death during newborn and post-newborn hospitalizations among preterm infants
早产儿新生儿和新生儿住院期间死亡的危险因素
- DOI:
10.1038/s41372-022-01363-z - 发表时间:
2022 - 期刊:
- 影响因子:2.9
- 作者:
N. Matoba;Soyang Kwon;J. Collins;Matthew M Davis - 通讯作者:
Matthew M Davis
Being specific about being special: defining children's conditions and special health care needs.
明确特殊性:定义儿童的状况和特殊的医疗保健需求。
- DOI:
10.1001/archpedi.161.10.1003 - 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
Matthew M Davis;J. Brosco - 通讯作者:
J. Brosco
Reimbursement for Prevnar: a modern-day version of Hercules and the Hydra.
Prevnar 的报销:现代版的大力神和九头蛇。
- DOI:
- 发表时间:
2002 - 期刊:
- 影响因子:8
- 作者:
G. Freed;Matthew M Davis;M. Andreae;Susan Bass;H. Weinblatt - 通讯作者:
H. Weinblatt
Correction to: Hospital discharges for fever and neutropenia in pediatric cancer patients: United States, 2009
更正:儿童癌症患者因发烧和中性粒细胞减少症出院:美国,2009 年
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:3.8
- 作者:
Emily L. Mueller;K. Walkovich;R. Mody;A. Gebremariam;Matthew M Davis - 通讯作者:
Matthew M Davis
Increasing Incidence and Geographic Distribution of Neonatal Abstinence Syndrome: United States 2009-2012
新生儿戒断综合症发病率上升及地理分布:美国 2009-2012 年
- DOI:
- 发表时间:
2015 - 期刊:
- 影响因子:2.9
- 作者:
S. Patrick;Matthew M Davis;C. U. Lehman;W. Cooper - 通讯作者:
W. Cooper
Matthew M Davis的其他文献
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{{ truncateString('Matthew M Davis', 18)}}的其他基金
2-Generation Interventions to Improve Cardiovascular Health in Indiana and Illinois Through Home Visiting (2-NOURISH)
通过家访改善印第安纳州和伊利诺伊州心血管健康的第二代干预措施 (2-NOURISH)
- 批准号:
10427796 - 财政年份:2022
- 资助金额:
$ 81.48万 - 项目类别:
Using MEPS Data to Inform Public-Plan Consumerism
使用 MEPS 数据为公共计划消费主义提供信息
- 批准号:
7322652 - 财政年份:2007
- 资助金额:
$ 81.48万 - 项目类别:
Understanding & Estimating Costs of Vaccine Development,Production and Pricing
理解
- 批准号:
7282371 - 财政年份:2006
- 资助金额:
$ 81.48万 - 项目类别:
Understanding & Estimating Costs of Vaccine Development,Production and Pricing
理解
- 批准号:
7229176 - 财政年份:2006
- 资助金额:
$ 81.48万 - 项目类别:
Understanding & Estimating Costs of Vaccine Development,Production and Pricing
理解
- 批准号:
7684335 - 财政年份:2006
- 资助金额:
$ 81.48万 - 项目类别:
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