TRANSforma Tu Salud Dejando de Fumar: Advancing smoking cessation among transgender individuals

TRANSforma Tu Salud Dejando de Fumar：促进跨性别者戒烟

• 批准号: 10741034
• 负责人: Ines Aristegui
• 金额: $ 32.5万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-22 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10741034
• 关键词: 2 arm randomized control trial; Abstinence; Address; Adherence; Argentina; Behavior; Behavioral Research; Birth; Clinical Research; Cotinine; Country; Disparity; Effectiveness; Epidemiology; Ferrous fumarate; Fright; Gender Identity; HIV; Health; Healthcare; Image; Income; Individual; Intervention; Interview; Latin American; Latino; Latino Population; Lesbian Gay Bisexual Transgender; Literature; Medical; Mentors; Mexico; Modality; Modification; Multimedia; Participant; Persons; Pharmacy facility; Pilot Projects; Population; Prevalence; Printing; Procedures; Puerto Rico; Randomized; Randomized, Controlled Trials; Reporting; Research; Research Design; Research Personnel; Resources; Smoke; Smoker; Smoking; Smoking Cessation Intervention; Social support; Suicide attempt; Testing; Text; Tobacco; Work; arm; career; community based participatory research; cost; efficacy evaluation; experience; follow up assessment; follow-up; gender affirmation; gender dysphoria; gender expression; health care service; health care settings; housing instability; mHealth; maltreatment; nicotine replacement; pilot test; programs; recruit; satisfaction; sex; smoking abstinence; smoking cessation; social; standard of care; stressor; systematic review; text messaging intervention; transgender; translational study; usability; virtual

PROJECT SUMMARY Mobile health (mHealth) interventions are a promising modality for overcoming barriers and providing culturally appropriate treatment among transgender individuals. mHealth interventions may be appropriate among transgender individuals, as emergent evidence suggests that virtual spaces are used to access gender affirming support and resources. Moreover, mHealth interventions may enable authentic self-expression among transgender individuals, which is not always possible offline. Over the past 7 years, our team has developed Decídetexto, a culturally accommodated smoking cessation text messaging intervention for U.S. Latino smokers. Decídetexto has been expanded to different Latin American countries/regions (e.g., Mexico and Puerto Rico), and has been adapted to different populations (e.g., U.S. Latino smokers living with HIV). A recently completed randomized controlled trial (RCT) with U.S. Latino smokers (n=457) demonstrated that U.S. Latinos receiving the Decídetexto intervention were significantly more likely than those receiving standard of care (smoking cessation printed materials) to be smoking abstinent at Month 6 (34.1% vs 20.6%; p<0.001). Despite the proven effectiveness of Decídetexto among U.S. Latinos, we have identified that this intervention does not adequately address unique barriers to smoking cessation encountered by transgender individuals (e.g., low social support, gender dysphoria as a stressor, need for gender affirming medical procedures). We propose to integrate our expertise in mHealth, smoking cessation, transgender health care, community-based participatory research, and cultural accommodation to develop, pilot test (R21), and then formally evaluate (R33) TRANSformá Tu Salud Dejando de Fumar (Spanish for “TRANSform Your Health by Quitting Smoking”) – a culturally accommodated smoking cessation intervention for transgender individuals. TRANSformá Tu Salud Dejando de Fumar will consist of 1) a 12-week WhatsApp-based program that facilitates longitudinal and bidirectional multimedia-based (i.e., text, image, video, and audio) dialogue with participants, and 2) integration with an e-Pharmacy to access nicotine replacement therapy (NRT) at no cost. R21 Aim 1: Develop TRANSformá Tu Salud Dejando de Fumar, a culturally accommodated smoking cessation intervention for transgender individuals. R21 Aim 2: Assess the feasibility, acceptability, and preliminary impact of TRANSformá Tu Salud Dejando de Fumar among transgender individuals. R33 Aim 1: Assess the efficacy of TRANSformá Tu Salud Dejando de Fumar compared to standard of care on smoking abstinence at Month 6 among transgender individuals. R21-R33 Capacity building. We will build capacity for mHealth behavioral research through the engagement of early career investigators in mentored activities and through academic partnerships between the U.S. and Argentina.

项目摘要 移动健康（MHealth）干预措施是克服障碍并在文化上提供的一种有希望的方式 跨性别者的适当治疗。 MHealth干预措施可能是适当的 跨性别者，正如紧急证据表明，虚拟空间用于肯定性别 支持和资源。此外，MHealth干预措施可能会在 变性人，这并不总是可能的离线。在过去的7年中，我们的团队发展了 DeCídetexto是一种在文化上适应美国拉丁裔吸烟者的戒烟文本消息干预。 Decídetexto已扩展到不同的拉丁美洲国家/地区（例如墨西哥和波多黎各）， 并已适用于不同的人群（例如，感染艾滋病毒的美国拉丁裔吸烟者）。一个最近完成的 美国拉丁裔吸烟者（n = 457）的随机对照试验（RCT）证明，美国拉丁裔接受 与接受护理标准的人（吸烟）相比，Decídetexto干预的可能性要大得多 停止印刷材料）在第6个月戒烟（34.1％vs 20.6％； p <0.001）。尽管经过证明 在美国拉丁美洲人中，decídetexto的有效性，我们已经确定这种干预措施并不能充分 解决跨性别者遇到的戒烟的独特障碍（例如，社会支持低， 性别烦躁不安作为压力源，需要性别确认医疗程序）。我们建议整合我们的 MHealth，戒烟，跨性别医疗保健，基于社区的参与研究以及 开发的文化住宿，试点测试（R21），然后正式评估（R33） Dejando de Fumar（西班牙语“通过戒烟来改变您的健康”） - 一种文化容纳的 对跨性别者的戒烟干预。 TransformáutuSalud Dejandor Will 包括1）为12周的基于WhatsApp的计划，可促进纵向和双向基于多媒体 （即文本，图像，视频和音频）与参与者的对话，以及2）与e-permarmacy进行集成以访问 尼古丁替代疗法（NRT）免费。 R21 AIM 1：开发TransformtransformátuSalud Dejando de Fumar，一种文化容纳的戒烟 跨性别者的干预。 R21 AIM 2：评估可行性，可接受性和初步影响 R33 AIM 1：评估效率 与第6个月的戒烟标准相比 在变性人中。 R21-R33能力建设。我们将建立MHealth行为的能力 通过早期职业研究者参与重要活动和学术研究 美国和阿根廷之间的伙伴关系。