The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort

伊利诺伊州儿童发展研究 ECHO 怀孕和儿科队列

• 批准号: 10744548
• 负责人: Susan L Schantz
• 金额: $ 168.81万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10744548
• 关键词: Address; Award; Benzophenones; Birth; Birth Weight; Chemical Exposure; Chemicals; Child; Child Health; Cognition; Cognitive; Communities; Complex Mixtures; Conceptions; Consumption; Creativeness; Data; Data Collection; Development; Diet; Dietary Component; Discrimination; Enrollment; Ethnic Origin; Exposure to; Federally Qualified Health Center; Feedback; Focus Groups; Gestational Age; Goals; Health; Healthcare; Illinois; Incentives; Income; Individual; Language Delays; Language Development; Low Income Population; Low income; Measures; Methods; Modeling; Modification; Outcome; Paper; Participant; Pediatric cohort; Phase; Phenols; Pilot Projects; Poly-fluoroalkyl substances; Population Heterogeneity; Pregnancy; Pregnant Women; Protocols documentation; Psychosocial Stress; Public Health; Race; Reporting; Reproductive Health; Reproductive system; School-Age Population; Schools; Science; Series; Stress; Stressful Event; Structure; Systems Development; United States National Institutes of Health; Woman; Work; anogenital distance; autism spectrum disorder; cognitive development; cognitive function; cohort; community engagement; design; developmental disease; ethnic diversity; good diet; improved; indexing; infancy; interest; maternal stress; mathematical ability; mother nutrition; neurodevelopment; novel; novel strategies; patient oriented; perceived stress; perinatal outcomes; phthalates; pregnant; prenatal; prenatal exposure; prenatal stress; programs; racial diversity; reading ability; recruit; retention rate; stressor; success

PROJECT SUMMARY This is a competitive renewal application (1) to continue to follow children in the Illinois Kids Development Study (IKIDS) who are Level 2 participants in ECHO, and (2) to continue recruiting new pregnant women into the IKIDS- ECHO cohort. A key goal of our continued recruiting effort is to increase the racial/ethnic and income diversity of our cohort through new recruiting partnerships with community agencies – the Champaign-Urbana Public Health District (CUPHD) and Promise Health Care (our local federally qualified health center) – that serve a primarily low-income, racially and ethnically diverse population of pregnant women. Specifically, we propose to enroll 660 additional pregnant women (and their conceiving partners, if available) through our partnerships with these two entities during the next phase of ECHO. We will rely heavily on community engagement, input from an established Community Advisory Board, and feedback from focus groups to develop recruitment and retention strategies that are effective for both retaining our current Level 2 participants and recruiting, enrolling, and retaining new pregnant participants. A subset of these participants who report a moderate to high likelihood of becoming pregnant again will be enrolled in the planned preconception pilot study. Our scientific aims will be addressed in a series of ECHO Concept Papers and will build on our previous work investigating the impacts of maternal prenatal stress or chemical exposures on birth outcomes and neurodevelopment. Leveraging data from multiple ECHO cohorts will allow us to apply state-of-the-art mixtures methods to investigate the impact of multiple chemical and non-chemical stressors on birth outcomes (gestational age at birth; birth weight; anogenital distance) and child cognitive development (specific domains from the NIH toolbox cognitive battery; measures of language development). We will also use novel approaches to evaluate the ability of a healthy maternal diet to mitigate the negative impact of these exposures on our outcomes of interest. Our hypothesis is that multiple prenatal stressors and/or chemical exposures jointly impact child neurodevelopment and birth outcomes, and these impacts can be mitigated by a healthy diet. We will use multiple measures of prenatal psychosocial stress from the core ECHO protocol (Aim 1), multiple studied and novel phthalates/replacements and phenols from the ECHO-WC-HHEAR novel chemicals analysis (Aim 2) or both chemicals and stressors in our mixtures models. To assess the impact of diet, we will use a novel approach in which we will include multiple dietary components calculated using established diet quality indices, together with multiple measures of maternal psychosocial stress or multiple chemicals, to understand the cumulative effects of the diet/stress or diet/chemical mixture and to evaluate if particular components of healthier diets can lessen or negate adverse associations of maternal stress or chemical exposures with child cognition or birth outcomes. Lastly, an exploratory aim will evaluate associations of maternal preconception stressors with (1) birth outcomes and (2) neurodevelopment during infancy.

项目总结