The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort

伊利诺伊州儿童发展研究 ECHO 怀孕和儿科队列

基本信息

项目摘要

PROJECT SUMMARY This is a competitive renewal application (1) to continue to follow children in the Illinois Kids Development Study (IKIDS) who are Level 2 participants in ECHO, and (2) to continue recruiting new pregnant women into the IKIDS- ECHO cohort. A key goal of our continued recruiting effort is to increase the racial/ethnic and income diversity of our cohort through new recruiting partnerships with community agencies – the Champaign-Urbana Public Health District (CUPHD) and Promise Health Care (our local federally qualified health center) – that serve a primarily low-income, racially and ethnically diverse population of pregnant women. Specifically, we propose to enroll 660 additional pregnant women (and their conceiving partners, if available) through our partnerships with these two entities during the next phase of ECHO. We will rely heavily on community engagement, input from an established Community Advisory Board, and feedback from focus groups to develop recruitment and retention strategies that are effective for both retaining our current Level 2 participants and recruiting, enrolling, and retaining new pregnant participants. A subset of these participants who report a moderate to high likelihood of becoming pregnant again will be enrolled in the planned preconception pilot study. Our scientific aims will be addressed in a series of ECHO Concept Papers and will build on our previous work investigating the impacts of maternal prenatal stress or chemical exposures on birth outcomes and neurodevelopment. Leveraging data from multiple ECHO cohorts will allow us to apply state-of-the-art mixtures methods to investigate the impact of multiple chemical and non-chemical stressors on birth outcomes (gestational age at birth; birth weight; anogenital distance) and child cognitive development (specific domains from the NIH toolbox cognitive battery; measures of language development). We will also use novel approaches to evaluate the ability of a healthy maternal diet to mitigate the negative impact of these exposures on our outcomes of interest. Our hypothesis is that multiple prenatal stressors and/or chemical exposures jointly impact child neurodevelopment and birth outcomes, and these impacts can be mitigated by a healthy diet. We will use multiple measures of prenatal psychosocial stress from the core ECHO protocol (Aim 1), multiple studied and novel phthalates/replacements and phenols from the ECHO-WC-HHEAR novel chemicals analysis (Aim 2) or both chemicals and stressors in our mixtures models. To assess the impact of diet, we will use a novel approach in which we will include multiple dietary components calculated using established diet quality indices, together with multiple measures of maternal psychosocial stress or multiple chemicals, to understand the cumulative effects of the diet/stress or diet/chemical mixture and to evaluate if particular components of healthier diets can lessen or negate adverse associations of maternal stress or chemical exposures with child cognition or birth outcomes. Lastly, an exploratory aim will evaluate associations of maternal preconception stressors with (1) birth outcomes and (2) neurodevelopment during infancy.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Susan L Schantz其他文献

Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
回声队列研究中产前尿三聚氰胺、三聚氰胺类似物和芳香胺与妊娠期和胎儿生长的关联
  • DOI:
    10.1016/j.envint.2024.109227
  • 发表时间:
    2025-01-01
  • 期刊:
  • 影响因子:
    9.700
  • 作者:
    Giehae Choi;Xiaoshuang Xun;Deborah H. Bennett;John D. Meeker;Rachel Morello-Frosch;Sheela Sathyanarayana;Susan L Schantz;Leonardo Trasande;Deborah Watkins;Edo D. Pellizzari;Wenlong Li;Kurunthachalam Kannan;Tracey J. Woodruff;Jessie P. Buckley;for the ECHO Cohort Consortium
  • 通讯作者:
    for the ECHO Cohort Consortium
Interrogating Components of 2 Diet Quality Indices in Pregnancy using a Supervised Statistical Mixtures Approach
使用有监督的统计混合方法对妊娠期两种饮食质量指数的成分进行询问
  • DOI:
    10.1016/j.ajcnut.2023.05.020
  • 发表时间:
    2023-07-01
  • 期刊:
  • 影响因子:
    6.900
  • 作者:
    Diana C Pacyga;Diana K Haggerty;Chris Gennings;Susan L Schantz;Rita S Strakovsky
  • 通讯作者:
    Rita S Strakovsky

Susan L Schantz的其他文献

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{{ truncateString('Susan L Schantz', 18)}}的其他基金

Organophosphate flame retardants exposure during pregnancy, maternal thyroid hormone disruption and early infant cognition
怀孕期间接触有机磷阻燃剂、母体甲状腺激素破坏和婴儿早期认知
  • 批准号:
    10177664
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
ECHO Supplement to Promote Diversity in Health-Related Research
ECHO 补充剂促进健康相关研究的多样性
  • 批准号:
    10412218
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
  • 批准号:
    10011911
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
ECHO Supplement
回声补充
  • 批准号:
    10412797
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
  • 批准号:
    10685822
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
  • 批准号:
    10240465
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
  • 批准号:
    9341310
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
  • 批准号:
    9197555
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
  • 批准号:
    10476634
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
  • 批准号:
    9355726
  • 财政年份:
    2016
  • 资助金额:
    $ 168.81万
  • 项目类别:

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