ECHO Supplement to Promote Diversity in Health-Related Research
ECHO 补充剂促进健康相关研究的多样性
基本信息
- 批准号:10412218
- 负责人:
- 金额:$ 13.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAttentionBenzophenonesBiological MarkersBirthBirth WeightCaliforniaChemical ExposureChild HealthChronicChronic stressComplexConsumptionCorticotropin-Releasing HormoneDataData AnalysesData CollectionData SetDevelopmentEndocrine DisruptorsEtiologyExposure toFetal GrowthGeographyGestational AgeGreen spaceHealthHouseholdIllinoisIntakeLengthLeukocytesMeasurementMeasuresMediatingMethodologyMicronutrientsMineralsNeighborhoodsOutcomeParabensParentsPatternPhenolsPlasmaPoly-fluoroalkyl substancesPregnancyPregnant WomenProtocols documentationPsychosocial StressResearchSan FranciscoShapesShort-Term MemorySocial PerceptionSocial statusSocioeconomic StatusSourceStressTriclosanUmbilical cord structureUniversitiesVitaminsadverse birth outcomesbasebiological adaptation to stressbuilt environmentcognitive developmentcognitive functioncohortdata harmonizationdata managementearly childhoodethnic diversityexperienceimprovedindexinginfancyinformation processinginnovationmaternal stressmother nutritionneurodevelopmentoffspringprenatalprenatal exposureprenatal stressprofessional atmosphereracial diversityrecruitresiliencesocial cognitionsocial stresssocioeconomicsstress resiliencetelomeretriclocarbanvirtual
项目摘要
PROJECT SUMMARY – Parent UH3 OD023272
We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the
University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and
ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal
psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of
highproduction volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which
research suggests may impact development, but for which data on child health outcomes is sparse: phenols
(bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl
substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual - perceptions
of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based
– neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3)
Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone
(CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we
will use innovative approaches to assess basic cognitive functions including working memory, attention,
information processing, and social cognition in infancy and early childhood. We will address three specific
aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth
outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal
stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this
aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual
and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed
relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of
offspring. During the planning period, we will harmonize data collection and management (including
biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our
two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis
Center. During UG3 stage we will also actively participate in development and implementation of the ECHO-
wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive
development and our experiences integrating and harmonizing data collection across our two geographically
distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing
a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of
resilience in order to understand the complex set of prenatal etiologic factors that shape developmental
outcomes in infancy and early childhood.
项目摘要 – 父级 UH3 OD023272
我们建议整合伊利诺伊大学和伊利诺伊大学目前正在招募的两个怀孕队列
加州大学旧金山分校 (UCSF) 旨在形成一个在地理、社会经济、种族和
种族多样化队列(ECHO.CA.IL)研究化学品暴露和孕产妇的累积影响
社会心理压力对出生结果和早期神经发育的影响。我们将重点关注两组
孕妇中经常检测到高产量的内分泌干扰化学物质(EDC),这
研究表明可能会影响发育,但有关儿童健康结果的数据很少:苯酚
(双酚、二苯甲酮、二氯酚、对羟基苯甲酸酯、三氯生、三氯卡班)和全氟烷基
物质(PFAS)。我们将衡量慢性压力和复原力的三个指标:1)感知 - 看法
家庭、邻里和工作环境中的社会地位和压力暴露; 2)基于地点
– 社区层面的社会经济地位、公民参与、绿色空间和建筑环境;和 3)
生物标志物 - 母体和脐带白细胞的端粒长度以及促肾上腺皮质激素释放激素
母体血浆中的 (CRH) 水平。我们将测量出生结果(出生体重和胎龄)并且我们
将使用创新方法来评估基本认知功能,包括工作记忆、注意力、
婴儿期和幼儿期的信息处理和社会认知。我们将解决三个具体问题
目标:(1) 评估产前 EDC 暴露与不良分娩措施之间的关系
后代的结果和认知发展。 (2) 评估产前测量之间的关系
不良出生结局和后代认知发展的压力和措施。重要的是,为此
我们还将评估压力反应的生物标志物是否介导知觉之间的关系
以及基于地点的压力和发展结果。 (3) 评估母亲压力是否改变观察到的
EDC 暴露与不良出生结果或认知发展测量之间的关系
后代。在规划期间,我们将统一数据收集和管理(包括
生物样本、压力测量以及出生结果和认知功能的测量)
两个队列准备合并我们的两个数据集并与 ECHO 数据分析共享我们的数据
中心。在UG3阶段我们还将积极参与ECHO-的开发和实施
广泛的研究方案提供评估母亲压力、后代认知的专业知识和方法
发展以及我们在整合和协调两个地理区域的数据收集方面的经验
不同的妊娠队列。总之,我们的创新研究方法将通过提供以下内容为 ECHO 做出贡献:
将累积化学品暴露与慢性社会心理压力和来源相结合的框架
恢复力,以了解影响发育的一系列复杂的产前病因
婴儿期和幼儿期的结果。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan L Schantz其他文献
Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
回声队列研究中产前尿三聚氰胺、三聚氰胺类似物和芳香胺与妊娠期和胎儿生长的关联
- DOI:
10.1016/j.envint.2024.109227 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:9.700
- 作者:
Giehae Choi;Xiaoshuang Xun;Deborah H. Bennett;John D. Meeker;Rachel Morello-Frosch;Sheela Sathyanarayana;Susan L Schantz;Leonardo Trasande;Deborah Watkins;Edo D. Pellizzari;Wenlong Li;Kurunthachalam Kannan;Tracey J. Woodruff;Jessie P. Buckley;for the ECHO Cohort Consortium - 通讯作者:
for the ECHO Cohort Consortium
Interrogating Components of 2 Diet Quality Indices in Pregnancy using a Supervised Statistical Mixtures Approach
使用有监督的统计混合方法对妊娠期两种饮食质量指数的成分进行询问
- DOI:
10.1016/j.ajcnut.2023.05.020 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Diana C Pacyga;Diana K Haggerty;Chris Gennings;Susan L Schantz;Rita S Strakovsky - 通讯作者:
Rita S Strakovsky
Susan L Schantz的其他文献
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{{ truncateString('Susan L Schantz', 18)}}的其他基金
Organophosphate flame retardants exposure during pregnancy, maternal thyroid hormone disruption and early infant cognition
怀孕期间接触有机磷阻燃剂、母体甲状腺激素破坏和婴儿早期认知
- 批准号:
10177664 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10011911 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10685822 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
- 批准号:
9341310 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10240465 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort
伊利诺伊州儿童发展研究 ECHO 怀孕和儿科队列
- 批准号:
10744548 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
- 批准号:
9197555 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10476634 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
9355726 - 财政年份:2016
- 资助金额:
$ 13.48万 - 项目类别:
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