Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
基本信息
- 批准号:10011911
- 负责人:
- 金额:$ 217.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-21 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:AchievementAddressAttentionBenzophenonesBiological MarkersBirthBirth WeightBloodCaliforniaChemical ExposureChemicalsChild DevelopmentChild HealthChildhoodChronicChronic stressCognitiveCollectionComplexCorticotropin-Releasing HormoneDataData AnalysesData CollectionData SetDevelopmentEndocrine DisruptorsEnvironmental ExposureEnvironmental PolicyEtiologyExposure toGeographyGestational AgeGreen spaceHairHouseholdIllinoisImpaired cognitionIndividualInfantInterdisciplinary StudyInterventionJointsLengthLeukocytesLifeMeasurementMeasuresMediatingMethodologyMothersNeighborhoodsNeonatalOutcomeParabensParticipantPerceptionPhenolsPlasmaPoly-fluoroalkyl substancesPregnancyPregnancy HistoriesPregnant WomenProductionProtocols documentationPsychosocial StressResearchSan FranciscoShapesShort-Term MemorySocial PerceptionSocial PoliciesSocial statusSocioeconomic StatusSourceStandardizationStressStructure of nail of toeTriclosanUmbilical Cord BloodUmbilical cord structureUnit of MeasureUniversitiesUrineadverse birth outcomesadverse pregnancy outcomebasebiological adaptation to stressbuilt environmentcognitive developmentcognitive functioncohortdata harmonizationdata managementearly childhoodethnic diversityexperiencefetalhuman datahuman tissueindexinginfancyinformation processinginnovationmaternal stressneurodevelopmentnovelnovel strategiesoffspringpostnatalprenatalprenatal exposureprenatal stressprofessional atmosphereprogramsracial diversityrecruitresilienceresponse biomarkersocial cognitionsocial stresssocial stressorsocioeconomicsstress resiliencetelomeretriclocarban
项目摘要
PROJECT SUMMARY
We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the
University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and
ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal
psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of high-
production volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which
research suggests may impact development, but for which data on child health outcomes is sparse: phenols
(bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl
substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual - perceptions
of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based
– neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3)
Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone
(CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we
will use innovative approaches to assess basic cognitive functions including working memory, attention,
information processing, and social cognition in infancy and early childhood. We will address three specific
aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth
outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of
prenatal stress and measures of adverse birth outcomes and cognitive development of offspring.
Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship
between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal
stress modifies observed relationships between EDC exposures and measures of adverse birth
outcomes or cognitive development of offspring. During the planning period, we will harmonize data
collection and management (including biospecimens, stress measurements, and measurements of birth
outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for
sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in
development and implementation of the ECHO-wide study protocol contributing expertise and methodology for
assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing
data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research
approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with
chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal
etiologic factors that shape developmental outcomes in infancy and early childhood.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan L Schantz其他文献
Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
回声队列研究中产前尿三聚氰胺、三聚氰胺类似物和芳香胺与妊娠期和胎儿生长的关联
- DOI:
10.1016/j.envint.2024.109227 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:9.700
- 作者:
Giehae Choi;Xiaoshuang Xun;Deborah H. Bennett;John D. Meeker;Rachel Morello-Frosch;Sheela Sathyanarayana;Susan L Schantz;Leonardo Trasande;Deborah Watkins;Edo D. Pellizzari;Wenlong Li;Kurunthachalam Kannan;Tracey J. Woodruff;Jessie P. Buckley;for the ECHO Cohort Consortium - 通讯作者:
for the ECHO Cohort Consortium
Interrogating Components of 2 Diet Quality Indices in Pregnancy using a Supervised Statistical Mixtures Approach
使用有监督的统计混合方法对妊娠期两种饮食质量指数的成分进行询问
- DOI:
10.1016/j.ajcnut.2023.05.020 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Diana C Pacyga;Diana K Haggerty;Chris Gennings;Susan L Schantz;Rita S Strakovsky - 通讯作者:
Rita S Strakovsky
Susan L Schantz的其他文献
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{{ truncateString('Susan L Schantz', 18)}}的其他基金
Organophosphate flame retardants exposure during pregnancy, maternal thyroid hormone disruption and early infant cognition
怀孕期间接触有机磷阻燃剂、母体甲状腺激素破坏和婴儿早期认知
- 批准号:
10177664 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
ECHO Supplement to Promote Diversity in Health-Related Research
ECHO 补充剂促进健康相关研究的多样性
- 批准号:
10412218 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10685822 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
- 批准号:
9341310 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10240465 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort
伊利诺伊州儿童发展研究 ECHO 怀孕和儿科队列
- 批准号:
10744548 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
- 批准号:
9197555 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10476634 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
9355726 - 财政年份:2016
- 资助金额:
$ 217.55万 - 项目类别:
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