Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development

产前压力和化学品暴露对儿童发育的累积影响

• 批准号: 10011911
• 负责人: Susan L Schantz
• 金额: $ 217.55万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10011911
• 关键词: Achievement; Address; Attention; Benzophenones; Biological Markers; Birth; Birth Weight; Blood; California; Chemical Exposure; Chemicals; Child Development; Child Health; Childhood; Chronic; Chronic stress; Cognitive; Collection; Complex; Corticotropin-Releasing Hormone; Data; Data Analyses; Data Collection; Data Set; Development; Endocrine Disruptors; Environmental Exposure; Environmental Policy; Etiology; Exposure to; Geography; Gestational Age; Green space; Hair; Household; Illinois; Impaired cognition; Individual; Infant; Interdisciplinary Study; Intervention; Joints; Length; Leukocytes; Life; Measurement; Measures; Mediating; Methodology; Mothers; Neighborhoods; Neonatal; Outcome; Parabens; Participant; Perception; Phenols; Plasma; Poly-fluoroalkyl substances; Pregnancy; Pregnancy Histories; Pregnant Women; Production; Protocols documentation; Psychosocial Stress; Research; San Francisco; Shapes; Short-Term Memory; Social Perception; Social Policies; Social status; Socioeconomic Status; Source; Standardization; Stress; Structure of nail of toe; Triclosan; Umbilical Cord Blood; Umbilical cord structure; Unit of Measure; Universities; Urine; adverse birth outcomes; adverse pregnancy outcome; base; biological adaptation to stress; built environment; cognitive development; cognitive function; cohort; data harmonization; data management; early childhood; ethnic diversity; experience; fetal; human data; human tissue; indexing; infancy; information processing; innovation; maternal stress; neurodevelopment; novel; novel strategies; offspring; postnatal; prenatal; prenatal exposure; prenatal stress; professional atmosphere; programs; racial diversity; recruit; resilience; response biomarker; social cognition; social stress; social stressor; socioeconomics; stress resilience; telomere; triclocarban

PROJECT SUMMARY We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of high- production volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which research suggests may impact development, but for which data on child health outcomes is sparse: phenols (bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual - perceptions of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based – neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3) Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone (CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we will use innovative approaches to assess basic cognitive functions including working memory, attention, information processing, and social cognition in infancy and early childhood. We will address three specific aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring. During the planning period, we will harmonize data collection and management (including biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in development and implementation of the ECHO-wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal etiologic factors that shape developmental outcomes in infancy and early childhood.

项目概要 我们建议整合伊利诺伊大学和伊利诺伊大学目前正在招募的两个怀孕队列 加州大学旧金山分校 (UCSF) 旨在形成一个在地理、社会经济、种族和 种族多样化队列（ECHO.CA.IL）研究化学品暴露和孕产妇的累积影响 社会心理压力对出生结果和早期神经发育的影响。我们将重点关注两组高 孕妇中定期检测到的内分泌干扰化学物质（EDC）的产量， 研究表明可能会影响发育，但有关儿童健康结果的数据很少：苯酚 （双酚、二苯甲酮、二氯酚、对羟基苯甲酸酯、三氯生、三氯卡班）和全氟烷基 物质（PFAS）。我们将衡量慢性压力和复原力的三个指标：1）感知 - 看法 家庭、邻里和工作环境中的社会地位和压力暴露； 2）基于地点 – 社区层面的社会经济地位、公民参与、绿色空间和建筑环境；和 3) 生物标志物 - 母体和脐带白细胞的端粒长度以及促肾上腺皮质激素释放激素 母体血浆中的 (CRH) 水平。我们将测量出生结果（出生体重和胎龄）并且我们 将使用创新方法来评估基本认知功能，包括工作记忆、注意力、 婴儿期和幼儿期的信息处理和社会认知。我们将解决三个具体问题 目标：(1) 评估产前 EDC 暴露与不良分娩措施之间的关系 后代的结果和认知发展。 (2) 评估措施之间的关系 产前应激以及不良出生结局和后代认知发展的测量。 重要的是，为了这个目标，我们还将评估压力反应的生物标志物是否介导这种关系 感知压力和基于地点的压力与发展结果之间的关系。 (3)评估母亲是否 压力改变了观察到的 EDC 暴露与不良分娩措施之间的关系 后代的结果或认知发展。在规划期间，我们将协调数据 收集和管理（包括生物样本、压力测量和出生测量 结果和认知功能）在我们的两个队列中准备合并我们的两个数据集并 与 ECHO 数据分析中心共享我们的数据。 UG3阶段我们也会积极参与 制定和实施 ECHO 范围内的研究方案，为以下方面贡献专业知识和方法 评估母亲的压力、后代的认知发展以及我们整合和协调的经验 收集我们两个地理位置不同的妊娠队列的数据。总而言之，我们的创新研究 该方法将通过提供一个将累积化学品暴露与 慢性心理社会压力和复原力来源，以了解复杂的产前心理压力 影响婴儿期和幼儿期发育结果的病因因素。