Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
基本信息
- 批准号:9197555
- 负责人:
- 金额:$ 24.57万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:AccountingAddressArchivesBasic ScienceBiologicalBiological AssayBiologyBlood CirculationCandidate Disease GeneCardiovascular DiseasesCellsChemical ExposureChemicalsChorionic GonadotropinCollectionConceptusCorticotropin-Releasing HormoneDataDetectionDevelopmentDevelopmental Delay DisordersDiethylhexyl PhthalateDiseaseEndocrineEndocrine DisruptorsEndothelial CellsEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEpidemiologistExposure toFetal Growth RetardationFunctional disorderFutureGene ExpressionGenesGenetic TranscriptionGenomicsGestational AgeGoalsHealthHome environmentHormonesHumanHuman DevelopmentIllinoisLibrariesLifeLinkLiquid substanceMachine LearningMeasuresMediatingMental disordersMessenger RNAMetabolic syndromeMethodsMicroRNAsMonitorMorbidity - disease rateMothersNatureNeurodevelopmental DisorderOrganOutcomeOutcome MeasureParticipantPatternPeptidesPlacentaPlacentationPopulationPre-EclampsiaPregnancyPregnancy TestsPregnant WomenPremature BirthPremature LaborProceduresRNAReportingResearchRoleSamplingSignal TransductionSmall RNASourceSpontaneous abortionStromal CellsStructureSurrogate MarkersSyncytiotrophoblastSyndromeTechniquesTestingTimeTissuesTranscriptUrineUterine cavityVillousabstractingage effectbasecell typeclinically relevantcohortcytotrophoblastdesigndevelopmental toxicologyextracellular vesiclesgenome-widein vivointerestmortalitymultidisciplinaryneonatal morbidityneurodevelopmentnoveloffspringperinatal morbiditypersonal care productsphthalatespostnatalprenatalresponsestudy populationtranscriptometranscriptome sequencingurinary
项目摘要
Project Summary/Abstract
The placenta is an essential organ in human development, and disruption of
its function can result in problems in pregnancy including miscarriage, preterm
labor, preeclampsia and intrauterine growth restriction. Additionally, disrupted
placenta function during pregnancy has been associated with a great number of
disorders and diseases that do not present until much later in the offspring's life
such as metabolic syndrome, cardiovascular diseases, developmental delay and
other neurodevelopmental and psychiatric disorders. How the exposures
encountered in the environment drive alterations in placenta structure and
function is poorly understood, and placenta function is difficult to assess in vivo
using noninvasive methods. We propose to understand how gene expression is
altered in the placenta during gestation by noninvasively characterizing the
placenta transcriptome in association with exposure to chemicals known to alter
endocrine signaling. These chemicals, called phthalates, are commonly found in
a variety of commercial products such as plastics and personal care products,
and phthalate exposure has also been shown to effect neurodevelopment. The
link between phthalate exposure and placenta gene expression in vivo is not yet
clear; therefore we have assembled a team comprised of neuroscientists,
placenta biologists, environmental epidemiologists, and genomics experts do
address how phthalate exposure and gestational age effects gene that are
expressed in the placenta but not in other tissues. One of the advantages of the
proposed research is that we will assess placenta gene expression noninvasively
through RNA molecules contained in extracellular vesicles that are secreted into
the urine of pregnant women. Collecting gene expression data and chemical
exposure data from urine is highly clinically relevant, and we expect our
approach will have clear translational applications just as home pregnancy tests
that rely on the detection of placenta produced hormones in urine have become
common. Our proposed study will provide the basic science background for the
development of rapid, noninvasive tests for assessing placenta function,
chemical exposures, and ultimately problems in neurodevelopment and other
danger signals during pregnancy.
项目总结/文摘
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan L Schantz其他文献
Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort
回声队列研究中产前尿三聚氰胺、三聚氰胺类似物和芳香胺与妊娠期和胎儿生长的关联
- DOI:
10.1016/j.envint.2024.109227 - 发表时间:
2025-01-01 - 期刊:
- 影响因子:9.700
- 作者:
Giehae Choi;Xiaoshuang Xun;Deborah H. Bennett;John D. Meeker;Rachel Morello-Frosch;Sheela Sathyanarayana;Susan L Schantz;Leonardo Trasande;Deborah Watkins;Edo D. Pellizzari;Wenlong Li;Kurunthachalam Kannan;Tracey J. Woodruff;Jessie P. Buckley;for the ECHO Cohort Consortium - 通讯作者:
for the ECHO Cohort Consortium
Interrogating Components of 2 Diet Quality Indices in Pregnancy using a Supervised Statistical Mixtures Approach
使用有监督的统计混合方法对妊娠期两种饮食质量指数的成分进行询问
- DOI:
10.1016/j.ajcnut.2023.05.020 - 发表时间:
2023-07-01 - 期刊:
- 影响因子:6.900
- 作者:
Diana C Pacyga;Diana K Haggerty;Chris Gennings;Susan L Schantz;Rita S Strakovsky - 通讯作者:
Rita S Strakovsky
Susan L Schantz的其他文献
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{{ truncateString('Susan L Schantz', 18)}}的其他基金
ECHO Supplement to Promote Diversity in Health-Related Research
ECHO 补充剂促进健康相关研究的多样性
- 批准号:
10412218 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Organophosphate flame retardants exposure during pregnancy, maternal thyroid hormone disruption and early infant cognition
怀孕期间接触有机磷阻燃剂、母体甲状腺激素破坏和婴儿早期认知
- 批准号:
10177664 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10011911 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10685822 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10240465 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Placental RNA Expression as a Function of Gestational Age and Environmental Exposures
胎盘 RNA 表达与胎龄和环境暴露的关系
- 批准号:
9341310 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
The Illinois Kids Development Study ECHO Pregnancy and Pediatric Cohort
伊利诺伊州儿童发展研究 ECHO 怀孕和儿科队列
- 批准号:
10744548 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
10476634 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
Cumulative Effects of Prenatal Stress and Chemical Exposures on Child Development
产前压力和化学品暴露对儿童发育的累积影响
- 批准号:
9355726 - 财政年份:2016
- 资助金额:
$ 24.57万 - 项目类别:
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