Organophosphate flame retardants exposure during pregnancy, maternal thyroid hormone disruption and early infant cognition

怀孕期间接触有机磷阻燃剂、母体甲状腺激素破坏和婴儿早期认知

• 批准号: 10177664
• 负责人: Susan L Schantz
• 金额: $ 11.27万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-21 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177664
• 关键词: Address; Age; Age-Months; Animals; Attention; Award; Benzophenones; Biological; Biological Markers; Birth; Birth Weight; California; Chemical Exposure; Chemicals; Child; Child Health; Chronic; Chronic stress; Cognition; Cognitive; Complex; Consumption; Corticotropin-Releasing Hormone; Data; Data Analyses; Data Collection; Data Set; Decision Making; Development; Endocrine Disruptors; Environmental Epidemiology; Etiology; Exposure to; Fetal Growth; Flame Retardants; Funding; Geography; Gestational Age; Goals; Grant; Green space; Health; Household; Human; Illinois; Individual; Infant; Infant Development; Intake; Knowledge; Latina; Length; Leukocytes; Linear Regressions; Link; Location; Measurement; Measures; Mediating; Mediation; Mentorship; Methodology; Methods; Micronutrients; Minerals; Modeling; Neighborhoods; Nurses; Organophosphates; Outcome; Paired Comparison; Parabens; Parents; Participant; Pathway interactions; Pattern; Perinatal; Phenols; Plasma; Poly-fluoroalkyl substances; Positioning Attribute; Pregnancy; Pregnant Women; Protocols documentation; Psychosocial Stress; Research; Research Personnel; Research Project Grants; San Francisco; Scientific Advances and Accomplishments; Scientist; Serum; Shapes; Short-Term Memory; Social Perception; Social status; Socioeconomic Status; Source; Statistical Methods; Stress; Structure; Technology; Thyroid Function Tests; Thyroid Hormones; Thyrotropin; Thyroxine; Training; Translational Research; Triclosan; Triiodothyronine; Umbilical cord structure; Universities; Visual; Visual attention; Vitamins; Woman; Writing; adverse birth outcomes; aged; base; biological adaptation to stress; built environment; career; clinical practice; cognitive development; cognitive function; cohort; data harmonization; data management; early childhood; environmental chemical exposure; ethnic diversity; experience; improved; indexing; infancy; information processing; innovation; maternal stress; mother nutrition; multidisciplinary; neurodevelopment; novel; offspring; prenatal; prenatal exposure; prenatal stress; professional atmosphere; racial diversity; recruit; reproductive; resilience; skills; social cognition; social stress; socioeconomics; stress resilience; telomere; thyroid disruption; triclocarban; urinary; virtual; visual tracking

PROJECT SUMMARY – Parent UH3 OD023272 We propose to integrate two pregnancy cohorts currently under recruitment at the University of Illinois and the University of California, San Francisco (UCSF) to form a larger geographically, socio-economically, racially and ethnically diverse cohort (ECHO.CA.IL) to study the cumulative impact of chemical exposures and maternal psychosocial stress on birth outcomes and early neurodevelopment. We will focus on two groups of highproduction volume endocrine disrupting chemicals (EDCs) regularly detected in pregnant women, which research suggests may impact development, but for which data on child health outcomes is sparse: phenols (bisphenols, benzophenone, dichlorophenols, parabens, triclosan, triclocarban) and perfluorinated alkyl substances (PFAS). We will measure three indices of chronic stress and resilience: 1) Perceptual - perceptions of social standing and stress exposures in household, neighborhood, and work environments; 2) Place-based – neighborhood level socioeconomic status, civic engagement, green space and built environment; and 3) Biomarkers - telomere length in maternal and umbilical cord leukocytes and corticotropin releasing hormone (CRH) levels in maternal plasma. We will measure birth outcomes (birth weight and gestational age) and we will use innovative approaches to assess basic cognitive functions including working memory, attention, information processing, and social cognition in infancy and early childhood. We will address three specific aims: (1) Evaluate the relationship between prenatal exposures to EDCs and measures of adverse birth outcomes and cognitive development of offspring. (2) Evaluate the relationship between measures of prenatal stress and measures of adverse birth outcomes and cognitive development of offspring. Importantly, for this aim we will also assess whether biomarkers of stress response mediate the relationship between perceptual and place-based stress and developmental outcomes. (3) Evaluate whether maternal stress modifies observed relationships between EDC exposures and measures of adverse birth outcomes or cognitive development of offspring. During the planning period, we will harmonize data collection and management (including biospecimens, stress measurements, and measurements of birth outcomes and cognitive functions) across our two cohorts to prepare for merging our two data sets and for sharing our data with the ECHO Data Analysis Center. During UG3 stage we will also actively participate in development and implementation of the ECHO- wide study protocol contributing expertise and methodology for assessing maternal stress, offspring cognitive development and our experiences integrating and harmonizing data collection across our two geographically distinct pregnancy cohorts. In summary, our innovative research approach will contribute to ECHO by providing a framework for integrating cumulative chemical exposures with chronic psychosocial stress and sources of resilience in order to understand the complex set of prenatal etiologic factors that shape developmental outcomes in infancy and early childhood.

项目摘要 – 父级 UH3 OD023272 我们建议整合伊利诺伊大学和伊利诺伊大学目前正在招募的两个怀孕队列 加州大学旧金山分校 (UCSF) 旨在形成一个在地理、社会经济、种族和 种族多样化队列（ECHO.CA.IL）研究化学品暴露和孕产妇的累积影响 社会心理压力对出生结果和早期神经发育的影响。我们将重点关注两组 孕妇中经常检测到高产量的内分泌干扰化学物质（EDC），这 研究表明可能会影响发育，但有关儿童健康结果的数据很少：苯酚 （双酚、二苯甲酮、二氯酚、对羟基苯甲酸酯、三氯生、三氯卡班）和全氟烷基 物质（PFAS）。我们将衡量慢性压力和复原力的三个指标：1）感知 - 看法 家庭、邻里和工作环境中的社会地位和压力暴露； 2）基于地点 – 社区层面的社会经济地位、公民参与、绿色空间和建筑环境；和 3) 生物标志物 - 母体和脐带白细胞的端粒长度以及促肾上腺皮质激素释放激素 母体血浆中的 (CRH) 水平。我们将测量出生结果（出生体重和胎龄）并且我们 将使用创新方法来评估基本认知功能，包括工作记忆、注意力、 婴儿期和幼儿期的信息处理和社会认知。我们将解决三个具体问题 目标：(1) 评估产前 EDC 暴露与不良分娩措施之间的关系 后代的结果和认知发展。 (2) 评估产前测量之间的关系 不良出生结局和后代认知发展的压力和措施。重要的是，为此 我们还将评估压力反应的生物标志物是否介导知觉之间的关系 以及基于地点的压力和发展结果。 (3) 评估母亲压力是否改变观察到的 EDC 暴露与不良出生结果或认知发展测量之间的关系 后代。在规划期间，我们将统一数据收集和管理（包括 生物样本、压力测量以及出生结果和认知功能的测量） 两个队列准备合并我们的两个数据集并与 ECHO 数据分析共享我们的数据 中心。在UG3阶段我们还将积极参与ECHO-的开发和实施 广泛的研究方案提供评估母亲压力、后代认知的专业知识和方法 发展以及我们在整合和协调两个地理区域的数据收集方面的经验 不同的妊娠队列。总之，我们的创新研究方法将通过提供以下内容为 ECHO 做出贡献： 将累积化学品暴露与慢性社会心理压力和来源相结合的框架 恢复力，以了解影响发育的一系列复杂的产前病因 婴儿期和幼儿期的结果。