Population-Based Epidemiologic Research

基于人群的流行病学研究

• 批准号: 10929838
• 负责人: kathleen r merikangas
• 金额: $ 59.46万
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10929838
• 关键词: Address; Adolescent; Adult; Age; Alcohols; Anxiety Disorders; Assessment tool; Attention deficit hyperactivity disorder; Behavior; Behavior Disorders; Behavioral; Biochemical; Brain; Brazil; COVID-19 pandemic; COVID-19 pandemic effects; COVID-19 risk; Canada; Cannabis; Cardiovascular Diseases; Caregivers; Child; Childhood; China; Clinical; Cohort Studies; Collaborations; Collection; Communication; Complement; Consult; Coronavirus; Country; Coupled; Data; Data Analyses; Data Collection; Data Pooling; Data Sources; Development; Disease; Education; Electronic cigarette; Emotional; Emotional disorder; Epidemiology; Ethnic Population; Etiology; Evaluation; Family Study; Feeling suicidal; Future; General Population; Genetic; Goals; Greece; Health; Health Surveys; Health behavior; Household; Hygiene; Impairment; Individual; Intervention; Interview; Investigation; Language; Link; Longitudinal Studies; Major Depressive Disorder; Manic; Measures; Medical; Mental Depression; Mental Health; Mental disorders; Mind; Monitor; Mood Disorders; Moods; National Institute of Mental Health; Nature; Neurodevelopmental Disorder; New York; Outcome; Parents; Participant; Patients; Pattern; Pennsylvania; Philadelphia; Physical activity; Physiological; Population Assessment of Tobacco and Health; Population Heterogeneity; Population Research; Population Study; Predisposition; Prevalence; Prevention; Primary Care; Property; Prospective Studies; Protocols documentation; Psyche structure; Psychometrics; Public Health; Publications; Publishing; Questionnaires; Recreation; Research; Research Personnel; Resources; Risk; Risk Factors; Risk Reduction; SARS-CoV-2 exposure; Sampling; Services; Severities; Sleep; Structure; Subgroup; Substance Use Disorder; Suicide; Suicide attempt; Surveys; Switzerland; Symptoms; System; Taiwan; Time; Tobacco use; Translating; Universities; Variant; Work; Youth; adolescent with autism spectrum disorder; adverse outcome; aged; autism spectrum disorder; behavioral health; cardiovascular risk factor; climate change; clinical practice; comorbidity; cost; data resource; data sharing; design; developmental genetics; disease classification; disorder risk; editorial; epidemiology study; evidence base; follow-up; genetic epidemiology; high risk; interest; knowledge base; marijuana legalization; marijuana use; mobile computing; next generation; novel strategies; offspring; pandemic disease; pandemic impact; pediatric department; physical conditioning; population based; preference; programs; prospective; psychiatric comorbidity; racial population; research study; residence; response; risk mitigation; screening; social; suicidal behavior; suicidal risk; systematic review; validation studies

We continue to leverage the National Comorbidity Survey (NCS-A) for its rich information on risk factors to expand the scientific knowledge base that can be used to inform prevention efforts. We examined the association of cannabis use with major depression and suicidal behavior (Hinckley et al, 2023), and found that cannabis use is associated with higher odds of depression and depression severity and found that depression and cannabis use are independently associated with higher odds of suicide attempt. Findings underscore a potential link between cannabis and suicide risk and the need for research on the temporal nature of these associations, particularly as recreational cannabis legalization expands. Using a naturalistic observational design, we assessed parent responses for over 1200 youth using a CRISIS survey (CRISIS AFAR) adapted for autism spectrum disorder (ASD) and related neurodevelopmental disorders (NDD). Analyses showed that the pandemic was associated with distinct patterns of symptom change among youth with ASD and NDD (Vibert et al, 2023). We identified 4 subgroups and their profiles revealed that symptom and service changes have distinct patterns of covariation among youth with ASD/NDD. Results suggested the COVID-19 pandemic impact on these groups varied, as in the general population. This study highlights the need for increased global coordination to include common assessment protocols and data structures to facilitate data sharing and analysis, in addition to longitudinal research aimed to assess and address the needs of the most vulnerable. We also used CRISIS data collected through HBN approximately 1 year after the initial pandemic to study associations between mental disorders and COVID-19 risk-mitigation practices among youth aged 5-21 (Conway et al, 2023). In this now published study, we found that youth with anxiety disorders were more likely to avoid high-risk exposure settings, and those with ADHD (combined type) were less likely to follow hygiene practices. Findings suggested that education and monitoring of risk-mitigation strategies in certain subgroups of youth may reduce risk of exposure to COVID-19 and other contagious diseases. We continued to work with CMI collaborators to study multinational survey data to assess parents'/caregivers' comfort with and preferences for pediatric mental health screening and related factors among 900 parents/caregivers (Kass et al, 2023). Despite slight variations based on country of residence, screening topic, and childs age, there was a cross-national parent/caregiver acceptability for mental health screening of their offspring, with preferences for f/u with experts who can facilitate further evaluation and treatment. This study suggests multinational interest in developing programs to detect and intervene in mental disorders in youths. In a systematic review with collaborators, we examined and cataloged scientific evidence on child and adolescent mental health in Greece, encompassing: prevalence estimates, assessment instruments, and interventions (Koumoula et al, 2023). The goal of this review was to develop a free collection of up-to-date evidence to serve as an interactive resource for clinical practice, https://rpubs.com/camhi/sysrev_table. This work may encourage similar assessments in other countries for child and adolescent mental health. With investigators at the NIMH, we studied the validity of the Ask Suicide-Screening Questions (ASQ) among black youth (Horowitz et al, 2022). We pooled data from 3 ASQ validation studies of over 1,000 pediatric medical patients aged 10-21, where participants had completed both the ASQ and the Suicidal Ideation Questionnaire. We found that there were no significant differences in ASQ psychometric properties between black and white youth, indicating that the ASQ is valid for screening black youth at risk for suicide. Future research is needed to confirm the validity of the ASQ among black youth and other racial and ethnic groups. Finally, we published an editorial discussing the widespread concern about the mental health of US youth and the need for novel approaches to estimate and track the magnitude of mental and behavioral disorders in the US and across the world (Merikangas & Salum, 2023). The most recent data on the prevalence and service patterns for the full range of mental disorders were collected nearly 20 years ago through the NCS-A study referenced above. Such information remains crucial, even though this type of research is becoming less feasible because of the high cost, sampling challenges, and rapid shifts in communication patterns through mobile technology that make household surveys increasingly obsolete. This editorial suggests a next generation of child and adolescent epidemiology that will focus on systematic data to help characterize the magnitude and impact of serious emotional disorders across development, coupled with education, intervention and prevention. Public Health Impact: Our research group continues to be at the forefront of coordinating the evidence base on epidemiology including prevalence, correlates and consequences of child and youth mental health through extensive collaborations with leaders in the field in the US, Canada, Brazil, the UK, Greece, Taiwan and China. The focus on developmental risk factors in the manifestations of emotional and behavioral conditions, which the NCS-A made possible, are critical for identifying targets for intervention and prevention of psychiatric disorders. Our studies of physical-mental comorbidity and sleep in adolescents and adults complement our family study research on the importance of physiological systems and behavioral rhythms in mental health and contribute to scientific understanding of psychiatric disorder etiology and opportunities for prevention. The CRISIS Consortium and continued collaboration with HBN will further our opportunity to conduct research aimed at reducing the adverse consequences of the COVID-19 pandemic and other influences on mental health problems among youth, which may have life-long positive benefit. Our growing collaborations with other research across the world will also facilitate our ability to identify the impact of global influences such as the COVID-19 pandemic and climate change as well as individual-level susceptibility on youth physical and mental health. Future Plans: We plan to continue our activity in the CRISIS Consortium that is now extending to broader efforts to track youth mental health through our collaborations with CMI and HBN, and parallel Brazilian, Canadian, and Swiss studies with intensive analysis of collected data on clinical features, risk factors, and impairment. We are also helping to design and implement a prospective follow-up of select HBN participants that will provide longitudinal information on patterns of symptoms, behaviors, and risk across time during development. Our team is also collaborating with the leaders of a recent nationwide study of youth in Canada, the CHSCY Canadian Health Survey of Children and Youth of more than 40,000 youth ages 7-21 across Canada. Now the data have been collected, we will consult on the priorities, analyses and interpretations of findings. We also plan to interrogate data from the PATH Study for associations between tobacco-product use (including e-cigarettes) and mental health problems. Across these rich data resources, we expect to continue publishing studies related to: 1) the intersection between physical and mental health; 2) the relationship between health behaviors such as sleep and activity and psychiatric disorders; 3) the influence of environmental and social exposures among children and youth; 4) associations between sleep, physical activity and mood disorders; and 5) subtypes of depression, mania and their core components.

我们继续利用国家合并症调查（NCS-A）获得有关危险因素的丰富信息，以扩大可用于预防工作的科学知识基础。我们检查了大麻使用与重度抑郁和自杀行为的关联（Hinckley等，2023），发现大麻的使用与抑郁症和抑郁症的严重程度较高有关，发现抑郁症和大麻的使用与自杀尝试的几率独立相关。调查结果强调了大麻与自杀风险之间的潜在联系以及对这些关联时间性质的研究的需求，尤其是随着休闲大麻合法化的扩大。 使用自然主义的观察设计，我们使用适合自闭症谱系障碍（ASD）和相关神经发育障碍（NDD）的危机调查（急症）评估了1200多名青年的父母反应。分析表明，大流行与ASD和NDD青年人的症状变化不同（Vibert等，2023）有关。我们确定了4个亚组，它们的概况表明，症状和服务变化具有不同的ASD/NDD青年的协方差模式。结果表明，与普通人群一样，共同19-19对这些群体的大流行影响各不相同。这项研究强调了增加全球协调的必要性，以包括共同的评估方案和数据结构，以促进数据共享和分析，此外旨在评估和满足最脆弱的需求的纵向研究。 在最初大流行后约1年，我们还使用了通过HBN收集的危机数据，以研究5-21岁的青年在精神障碍与Covid-19风险缓解实践之间的关联（Conway等，2023）。在这项现已发表的研究中，我们发现患有焦虑症的青年更有可能避免高风险的暴露环境，而患有多动症（合并类型）的年轻人则不太可能遵循卫生实践。调查结果表明，在某些年轻人亚组中，教育和监测降低风险的策略可能会降低暴露于19 Covid-19和其他传染性疾病的风险。 我们继续与CMI合作者合作研究跨国调查数据，以评估父母/护理人员对900名父母/护理人员的儿科心理健康筛查及相关因素的舒适感和偏好（Kass等，2023）。尽管基于居住国，筛查主题和儿童年龄的略有差异，但在其后代的心理健康筛查中有跨国父母/照顾者的可接受性，对F/U的偏好与可以促进进一步评估和治疗的专家偏爱。这项研究表明，跨国兴趣对开发计划以检测和干预年轻人的精神障碍。 在与合作者的系统综述中，我们研究并分类了有关希腊儿童和青少年心理健康的科学证据，包括：流行估计，评估工具和干预措施（Koumoula等，2023）。这篇评论的目的是开发免费的最新证据集，以作为临床实践的交互式资源，https://rpubs.com/camhi/sysrev_table。这项工作可能会鼓励其他国家对儿童和青少年心理健康的类似评估。 在NIMH的调查人员的情况下，我们研究了黑人青年中问候自杀问题（ASQ）的有效性（Horowitz等，2022）。我们从1,000多名10-21岁的儿科医学患者进行了3项ASQ验证研究中汇总了数据，参与者同时完成了ASQ和自杀意念问卷。我们发现，黑白青年之间的ASQ心理测量特性没有显着差异，这表明ASQ有效筛查有自杀风险的黑人青年。需要进行未来的研究以确认黑人青年以及其他种族和种族中ASQ的有效性。 最后，我们发表了一篇社论，讨论了人们对美国青年心理健康的广泛关注，以及对美国和世界各地的精神和行为障碍的新颖方法的需求（Merikangas＆Salum，2023年）。大约20年前，通过上述NCS-A研究收集了有关全部精神障碍的患病率和服务模式的最新数据。即使由于成本高昂，抽样挑战以及通过移动技术的沟通模式快速转移，这些类型的研究变得越来越不可行，尽管这种研究变得越来越不可行。该社论表明，下一代儿童和青少年流行病学将重点关注系统数据，以帮助表征整个发展中严重的情绪障碍的严重性和影响，再加上教育，干预和预防。 公共卫生影响： 我们的研究小组通过与美国，加拿大，巴西，英国，希腊，台湾和中国的领导者进行广泛的合作，继续处于协调流行病学证据基础的最前沿。 NCS-A所能实现的情绪和行为状况表现中对发展风险因素的关注对于确定干预和预防精神疾病的目标至关重要。我们对青少年和成年人的身体合并症和睡眠的研究补充了我们家庭研究对生理系统和行为节奏在心理健康中的重要性的研究，并有助于科学理解精神疾病的病因和预防机会。危机财团和与HBN的持续合作将进一步进行我们的机会进行研究，以减少199日大流行的不良后果以及对青年人心理健康问题的其他影响，这可能会带来终身积极的好处。我们与全球其他研究的日益增长的合作还将促进我们确定全球影响力的影响，例如COVID-19大流行和气候变化以及个人水平对青年身心健康的敏感性。 未来计划： 我们计划在危机联盟中继续我们的活动，该联盟现在正在扩展到通过与CMI和HBN以及平行巴西，加拿大和瑞士研究的合作来追踪青年心理健康的更广泛努力，并通过对收集的有关临床特征，危险因素和损害的收集数据进行了深入的分析。我们还有助于设计和实施一定的HBN参与者的前瞻性随访，这些随访将提供有关症状，行为和风险在开发过程中的纵向信息。我们的团队还与加拿大CHSCY的加拿大CHSCY健康调查对加拿大CHSCY健康调查的最新全国性研究的领导人合作，对加拿大7-21岁的儿童和青少年进行了调查。现在收集了数据，我们将咨询发现结果的优先级，分析和解释。我们还计划从路径研究中询问数据，以了解使用烟草产品（包括电子烟​​）和心理健康问题之间的关联。在这些丰富的数据资源中，我们希望继续发布与以下方面的发表研究：1）身心健康之间的交集； 2）睡眠，活动与精神疾病等健康行为之间的关系； 3）儿童和青少年环境和社会暴露的影响； 4）睡眠，体育锻炼和情绪障碍之间的关联； 5）抑郁症，躁狂症及其核心成分的亚型。

项目成果

Editorial: Shifting the Landscape of Child Psychiatric Epidemiology.

社论：改变儿童精神病学流行病学的格局。

• DOI: 10.1016/j.jaac.2023.05.006
• 发表时间: 2023
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry
• 影响因子: 13.3
• 作者: Merikangas,KathleenRies;Salum,GiovanniAbrahão
• 通讯作者: Salum,GiovanniAbrahão

A genetic risk score is differentially associated with migraine with and without aura.

• DOI: 10.1007/s00439-017-1816-5
• 发表时间: 2017-08
• 期刊: Human genetics
• 影响因子: 5.3
• 作者: Pisanu C;Preisig M;Castelao E;Glaus J;Pistis G;Squassina A;Del Zompo M;Merikangas KR;Waeber G;Vollenweider P;Mwinyi J;Schiöth HB
• 通讯作者: Schiöth HB

Validation and Feasibility of the ASQ Among Pediatric Medical and Surgical Inpatients.

• DOI: 10.1542/hpeds.2020-0087
• 发表时间: 2020-09-01
• 期刊: Hospital pediatrics
• 作者: Horowitz, Lisa M;Wharff, Elizabeth A;Bridge, Jeffrey A
• 通讯作者: Bridge, Jeffrey A

Heterogeneity in COVID-19 Pandemic-Induced Lifestyle Stressors and Predicts Future Mental Health in Adults and Children in the US and UK.

• DOI: 10.1101/2021.08.10.21261860
• 发表时间: 2021-08-11
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Nikolaidis, Aki;DeRosa, Jacob;Paksarian, Diana
• 通讯作者: Paksarian, Diana

Environmental factors in offspring of parents with mood disorders and their role in parent-child transmission: findings from a 14-year prospective high-risk study.

• DOI: 10.1186/s40345-022-00257-5
• 发表时间: 2022-04-06
• 期刊: International journal of bipolar disorders
• 影响因子: 4
• 作者: Moulin F;Gholam M;Strippoli MF;Castelao E;Merikangas KR;Stapp EK;Marquet P;Aubry JM;Plessen KJ;Di Giacomo F;Glaus J;Pistis G;Lavigne B;Elowe J;Ranjbar S;Preisig M;Vandeleur CL
• 通讯作者: Vandeleur CL