Einstein Aging Study

摘要 阿尔茨海默病和相关痴呆（ADRD）的病因是多因素的，鉴于目前缺乏 在疾病修饰治疗中，越来越需要更好地理解可修饰风险的作用 因素这个爱因斯坦老化研究计划项目（EAS P01）更新的总体目标是 阐明联系行为，社会/情绪和代谢健康以及环境因素的途径 在ADRD发作前认知功能下降。EAS队列是来自布朗克斯的一个多元化的社区样本 县，纽约州，并提供了机会，研究有关种族/民族差异的社会因素， 认知健康在当前的资助期内，我们开发并应用了生态瞬时评估 (EMA)方法，并将其与基于临床的强大认知表现指标相结合， 认知变化和认知能力下降的可改变风险因素。我们将通过以下方式扩大这一经验： 利用移动的设备来捕捉风险因素和认知表现的动态时变性质 参与者在进行日常活动时，我们的门诊评估经验与 我们在传统方法方面的专业知识和强大的统计专业知识是这项建议的主要优势。的 稳健的常规认知成套测验提供了认知状态和衰退的领域特异性测量， 支持轻度认知障碍（MCI）的诊断，并便于与其他研究进行比较。我们 提出了四个主题相关的项目，以衡量与主要认知相关的暴露， 结局：认知能力、认知下降、轻度认知障碍和血液AD 生物标志物。项目1将评估睡眠健康、身体活动和久坐行为的综合影响。 项目2将调查社会/情绪健康、炎症和 生物老化的标志。项目3将测量个人暴露于空气污染的情况，以调查 颗粒物暴露的影响。项目4在2型糖尿病患者中使用连续葡萄糖监测， 检查葡萄糖调节的效果。这些综合项目的资源和专门知识将 由六个紧密相连的核心支撑。这些综合资源将提高我们研究生物学的能力， 可能是暴露与认知结果（包括炎症）相关的机制， 血管过程神经退化的标志信息将为未来有针对性的干预措施提供信息， 防止ADRD延迟发作。EAS研究人员将继续指导初级研究人员培训下一个 在临床研究的创新方法的一代认知老化科学家。通过oongoing 通过国家和国际合作，EAS将继续作为ADRD研究的宝贵资源 社区

ABSTRACT The etiology of Alzheimer’s disease and related dementias (ADRD) is multifactorial and given the current lack of disease-modifying treatments, there is a growing need to better understand the roles of modifiable risk factors. The overarching goal of this Einstein Aging Study Program Project (EAS P01) renewal is to elucidate pathways linking behavioral, social/emotional and metabolic health, as well as environmental factors to cognitive decline prior to onset of ADRD. The EAS cohort is a diverse community-based sample from Bronx County, NY, and provides the opportunity to examine social factors related to racial/ethnic disparities in cognitive health. In the current funding period, we developed and applied ecological momentary assessment (EMA) methods and aligned them with robust clinic-based measures of cognitive performance to identify early cognitive changes and modifiable risk factors for cognitive decline. We will expand upon this experience by utilizing mobile devices that capture the dynamic time-varying nature of risk factors and cognitive performance as participants engage in their usual daily activities. Our experience with ambulatory assessment paired with our expertise in conventional methods and strong statistical expertise are major strengths of the proposal. The robust conventional cognitive battery provides domain specific measures of cognitive status and decline, supports the diagnosis of mild cognitive impairment (MCI) and facilitates comparison with other studies. We propose four thematically connected projects, to measure exposures in relation to the primary cognitive outcomes: cognitive performance, cognitive decline, mild cognitive impairment, and blood-based AD biomarkers. Project 1 will assess combined effects of sleep health, physical activity and sedentary behavior. Project 2 will investigate the independent, and joint effects of social/emotional health, inflammation and markers of biological aging. Project 3 will measure person-specific exposure to air pollution to investigate the effects of particulate matter exposure. Project 4 utilize continuous glucose monitoring in Type 2 diabetics to examine effects of glucose regulation. The resources and expertise within these integrated projects, will be supported by six closely linked cores. These combined resources will enhance our ability to examine biological mechanisms that may underlie associations of exposures with cognitive outcomes including inflammation, vascular processes, markers of neurodegeneration. Information will inform future targeted interventions to prevent of delay ADRD onset. EAS researchers will continue to mentor junior investigators to train the next generation of cognitive aging scientists in innovative approaches to clinical research. Through oongoing national and international collaborations the EAS will continue as a valuable resource for the ADRD research community.