Predoctoral Training in Pharmacological Sciences

项目摘要 这是一个“新的”T32资助申请，寻求对药理学科学培训（TIPS）的支持， 威尔康奈尔研究生院（WCGS）。如果被授予，这笔赠款将支持一个非常成功的积极 T32博士前培训计划，目前的资金定于2021年6月30日结束。我们的TIPS计划是跨- 部门和跨机构，包括33名优秀的教师导师，从威尔康奈尔大学组装 医学和纪念斯隆-凯特琳癌症中心。我们提供了非常丰富的研究 培训环境，包括最先进的仪器和核心设施，宽敞的空间 分配给TIPS计划，并继续致力于招聘最聪明和最好的新教师。 我们的机构已经作出了前所未有的承诺，以发展其生物医学研究计划， 在过去的15年里，从慈善事业中筹集的30亿美元用于新的建设和教师发展。 参与的教师是一个有凝聚力的世界级的研究人员与充满活力的正在进行的研究， 培养早期科学领导者和学者的坚实记录。我们是专业的导师和生物医学 拥有实验室的研究人员每年平均获得超过140万美元的研究支持。正式的导师培训是 对我们所有的教职员工都有义务，沿着对教职员工和招生委员会进行隐性偏见培训。 目前的教师包括22名教授，4名副教授和5名副教授，并制定了协议 用于增加和删除培训教员。该计划的一个主要重点是分享 激发学员的发现热情，培养学生的批判性推理能力， 所有必要的技能，以实现他们所拥有的培训提供的各种职业机会的愿望 我们提供。值得注意的是，在过去10年中，97%的博士毕业生继续从事研究或 研究相关的职业。我们的教师导师是高度合作，但与不同的研究兴趣- 为学员提供广泛的培训机会，包括转化生物医学， 神经药理学，癌症生物学，细胞信号传导，代谢，化学生物学，合成化学， 计算生物学和结构生物学。药理学项目采用了全面的审查程序 每年招收12-16名优秀学生。在总共88名报名者中 90.1%符合培训条件，其中24.3%来自URiM团体。过去5 2010年，新生的平均大学平均成绩为3.58，并且有26.2个月的研究经验。的 GRE考试不再作为录取指标，我们已经迁移到一个整体的审查过程， 甄选候选人时考虑到整体准备、动机和感知到的勇气。我们的2020 药理学课程班由15名学员组成，其中14名符合培训条件，2名来自 少数民族/多样性群体。我们为我们的毕业生所担任的重要职位感到自豪，包括过去/现在 政府、学术界、制药和生物技术领域的科学领导者-证明了我们的培训计划的好处。

Project Summary This is a “new” T32 grant application seeking support for Training in the Pharmacological Sciences (TIPS) at the Weill Cornell Graduate School (WCGS). If awarded, that grant will extend support for a highly successful active T32 predoctoral training program with current funding slated to end on June 30, 2021. Our TIPS Program is inter- departmental and inter-institutional, comprising 33 outstanding faculty mentors, assembled from the Weill Cornell Medicine and the Memorial Sloan-Kettering Cancer Center. We provide an exceedingly rich research environment for training, including state-of-the-art instrumentation and core facilities, a generous space allocation to the TIPS Program and a continuing commitment to recruitment of the brightest and best new faculty. Our institutions have made an unprecedented commitment to growing their biomedical research programs, with >$3 billion raised from philanthropy spent on new construction and faculty development during the past 15 years. The participating faculty are a cohesive group of world-class investigators with vibrant ongoing research and solid records of training early-stage scientific leaders and scholars. We are dedicated mentors and biomedical researchers with labs that receive an annual average research support >$1.4M. Formal mentorship training is obligate for all of our faculty members, along with implicit bias training for the faculty and admissions committee. The current faculty comprise 22 Professors, 4 Assoc. Professors and 5 Asst. Professors with protocols in place for both adding and removing training faculty members. A major emphasis of the Program is to share the excitement of discovery with trainees, cultivate the student’s capacity for critical reasoning, and instill in students all necessary skills to fulfill aspirations they possess for the diverse career opportunities afforded by the training we offer. Notably, 97% of PhD graduates during the past 10 years have continued in either research or a research-related career. Our faculty mentors are highly-collaborative, yet with diverse research interests – providing trainees broad training opportunities in areas that include translational biomedicine, neuropharmacology, cancer biology, cell signaling, metabolism, chemical biology, synthetic chemistry, computational biology and structural biology. The Pharmacology Program has adopted a holistic review process for predoctoral applicants and enrolls 12-16 outstanding trainees annually. Among the total group of 88 enrolled or incoming trainees, 90.1% are training-eligible and 24.3% of these are from URiM groups. During the past 5 years, incoming students had a mean college GPA of 3.58 and 26.2 months of prior research experience. The GRE exam is no longer used as an admissions metric and we have migrated to a holistic review process for selection of candidates that considers overall preparation, motivation and perceived grit. Our 2020 incoming Pharmacology Program class is a group of 15 trainees, with 14 that are training-eligible and 2 from minority/diversity groups. We are proud of the prominent positions held by our graduates, including past/present scientific leaders in government, academia, pharma and biotech - attesting to the benefit of our training Program.