Population Neuroscience of Aging and Alzheimer's Disease (PNA)

衰老和阿尔茨海默病的群体神经科学 (PNA)

• 批准号: 10626198
• 负责人: MARY GANGULI
• 金额: $ 35.24万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10626198
• 关键词: Aging; Alzheimer' s Disease; Neurosciences; Population

This is a proposal for the competing continuation of the T32 Training Program in Population Neuroscience of Aging & Alzheimer’s Disease (PNA), at the University of Pittsburgh, for 3 pre-doctoral and 2 post-doctoral fellows, each for up to 3 years. This proposal builds on a successful first cycle, with a recruitment of ten (10) trainees (50% from an underrepresented group as defined by the National Institutes of Health (NIH)) and 100% retention rate. Among the ten trainees, six (6) have been in the program for more than one year, with high scholarly achievement (>30 published manuscripts, 5 NIH grants submitted, 2 NIH grants funded), 100% attendance, 100% multidisciplinary projects, and 100% progression into research careers. The goal of the PNA program is to train a diverse cohort of pre- and post-doctoral scholars to pursue successful independent research in the etiology and pathophysiology of Alzheimer’s Disease and other age- related dementia (ADRD). The growing breadth and complexity of research in ADRD requires new multi- disciplinary curricula that move beyond a “linear sum” of single-discipline coursework. The PNA curriculum responds to this changing landscape with a multidisciplinary curriculum that integrates disciplines traditionally taught in separate departments: population sciences, neurosciences, gerontology, and data sciences. The PNA curriculum has four components: (1) Individual development plan, crafted and monitored by a multi- disciplinary mentoring team, (2) PNA-focused core courses that teach foundational knowledge in PNA, (3) Research practicum with clinical rotations for hands-on training in rigorous research; (4) professional development activities to lead and work with multi-disciplinary research teams. Trainees acquire tangible skills to pursue research careers in the academic, government, and private sectors, including: scientific reasoning, scientific writing and communication, study design, data management, statistics, and public speaking. The PNA Program is administered by the Department of Epidemiology, with co-Directors Dr. Ganguli in Psychiatry and Dr Rosano in Epidemiology, who share responsibility for all aspects of its function. The PNA training formula benefits from extensive resources at Pitt. The 32 PNA program faculty are affiliated with the Schools of Public Health (Epidemiology, Biostatistics), Arts and Science (Neuroscience, Psychology), Medicine (Neurology, Biomedical Informatics), as well as NIA-funded Centers of excellence and Institutes: the Alzheimer Disease Research Center, the Center for the Neural Basis of Cognition, the Brain Institute, the Center for Aging, Population and Health, the Aging Institute, the Claude Pepper, the Office of Academic Career and Development and the Teaching Institute. Trainees are recruited using proactive and personalized strategies, in collaboration with Institutional resources to promote diversity, equity, and inclusion. We implement a rigorous evaluation process annually, with input from trainees, alumni, faculty and the External Advisory Committee.

这是一项关于竞相延续T32培训计划的建议，该计划的目的是为了 匹兹堡大学老年与阿尔茨海默病(PNA)，3名博士前和2名博士后 研究员，每人最多3年。这项建议建立在成功的第一个周期的基础上，招聘了十(10)人 受训人员(50%来自国家卫生研究院(NIH)定义的代表性不足的群体)和100% 保留率。在十名学员中，六(6)人已参加该项目一年以上， 学术成就(&gt；30篇已发表手稿，5份国家卫生研究院拨款，2份国家卫生研究院拨款)，100% 出勤率，100%多学科项目，100%进入研究职业生涯。 PNA计划的目标是培养一批不同的博士后和博士后学者 在阿尔茨海默病和其他年龄段的病因学和病理生理学方面成功的独立研究- 相关痴呆症(ADRD)。ADRD研究的广度和复杂性不断增长，需要新的多方面的 超越单一学科课程作业的“线性总和”的学科课程。PNA课程 通过传统上整合各学科的多学科课程来应对不断变化的环境 在不同的系教授：人口科学、神经科学、老年学和数据科学。 PNA课程有四个组成部分：(1)个人发展计划，由多个 纪律指导小组，(2)以PNA为重点的核心课程，教授PNA基础知识，(3) 带临床轮换的研究实习，以进行严格的研究实践培训；(4)专业 开发活动，领导多学科研究团队并与之合作。学员获得有形技能 在学术、政府和私营部门从事研究工作，包括：科学推理， 科学写作和交流、研究设计、数据管理、统计和公开演讲。 PNA计划由流行病学系管理，联合主任甘古利博士在 精神病学和流行病学方面的罗萨诺博士，他们共同负责其所有方面的职能。巴勒斯坦民族权力机构 培训公式受益于PIT的广泛资源。32名PNA项目教职员工隶属于 公共卫生学院(流行病学、生物统计学)、文理学院(神经科学、心理学)、医学院 (神经学、生物医学信息学)，以及NIA资助的英才中心和研究所：阿尔茨海默病 疾病研究中心、认知神经基础中心、脑研究所、 老龄化，人口和健康，老龄研究所，克劳德·佩珀，学术事业办公室和 发展和教学研究所。 与机构资源合作，采用积极主动和个性化的战略招募学员 促进多样性、公平性和包容性。我们每年都会执行严格的评估过程，并提供投入 来自学员、校友、教职员工和外部咨询委员会。

项目成果

Feasibility and Enjoyment of Exercise Video Games in Older Adults.

• DOI: 10.3389/fpubh.2021.751289
• 发表时间: 2021
• 期刊: Frontiers in public health
• 影响因子: 5.2
• 作者: Freed SA;Sprague BN;Stephan AT;Doyle CE;Tian J;Phillips CB;Ross LA
• 通讯作者: Ross LA

Tutorials in population neuroimaging: Using epidemiology in neuroimaging research.

群体神经影像学教程：在神经影像学研究中使用流行病学。

• DOI: 10.3389/fnimg.2022.934514
• 发表时间: 2022
• 期刊: Frontiers in neuroimaging
• 作者: Godina,Sara;Jacob,MiniE;Ganguli,Mary
• 通讯作者: Ganguli,Mary

Cognitive training, mobility, and everyday life.

• DOI: 10.1016/s2666-7568(21)00200-2
• 发表时间: 2021-09
• 期刊: The lancet. Healthy longevity
• 作者: Sprague BN

Cognition and Cerebrovascular Reactivity in Midlife Women With History of Preeclampsia and Placental Evidence of Maternal Vascular Malperfusion.

具有先兆子痫病史和母体血管厌食症的胎盘史的中年女性的认知和脑血管反应性。

• DOI: 10.3389/fnagi.2021.637574
• 发表时间: 2021
• 期刊: Frontiers in aging neuroscience
• 影响因子: 4.8
• 作者: Shaaban CE;Rosano C;Cohen AD;Huppert T;Butters MA;Hengenius J;Parks WT;Catov JM
• 通讯作者: Catov JM

A viewpoint on change point modeling for cognitive aging research: Moving from description to intervention and practice.

• DOI: 10.1016/j.arr.2019.101003
• 发表时间: 2020-03
• 期刊: Ageing research reviews
• 影响因子: 13.1
• 作者: Sprague BN;Freed SA;Phillips CB;Ross LA
• 通讯作者: Ross LA