Risk factors for MCI and Dementia in a Diverse Senior Cohort

摘要/摘要 不同老年人队列中MCI和痴呆症的危险因素。基于社区的 关于轻度认知损害(MCI)和痴呆的研究相对较少 研究对象包括低收入的少数族裔老年人。PAR 15-356特别欢迎项目 建议扩大现有的纵向队列研究，增强多学科的力量 种族队列研究，并探索阿尔茨海默病(AD)风险的趋势。我们建议 使用密集的以社区为基础的外展活动，从低社会经济地位群体中招募800名老年人 人口60%为非裔美国人(AA)的行政区。这些行政区，包括 15104个邮政编码，在MYHAT(R01AG023651)的研究区域内，正在进行的人口- 2000+随机抽取老年人认知损害与痴呆的队列研究 在宾夕法尼亚州西南部。通过在拟议的新15104中使用MYHAT评估协议 志愿者队列，我们将通过以下方式收集相同的数据并经济高效地利用MYHAT数据 将这两组人汇集在一起进行分析。使用适当的采样权重调整我们的 对15104个队列的非随机样本选择的估计，我们将检查风险和 在汇集的队列中，弹性因素。我们将在以下位置确定与MCI相关的因素 基线，并通过年度后续评估，确定后续的风险因素 认知功能衰退和痴呆症。特别是，但不完全是，我们将重点关注风险因素 在AA高年级学生中很常见：受教育程度低，教育质量差，健康素养低， 载脂蛋白E*4基因、高血压、糖尿病和吸烟。然后我们将确定种族是否 修正风险因素和不良认知结果之间的关系。增强 少数族裔老年人的参与将使我们在解决 调查并最终解决认知健康差距的挑战 人口。

ABSTRACT/SUMMARY Risk factors for MCI and dementia in a diverse senior cohort. Community-based research on mild cognitive impairment (MCI) and dementia includes relatively few longitudinal studies that include low-income minority seniors. PAR 15-356 specifically welcomes projects that propose augmenting existing longitudinal cohort studies, enhancing the power of multi- ethnic cohort studies, and exploring trends in the risk of Alzheimer's disease (AD). We propose to use intensive community-based outreach to recruit 800 seniors from a low-SES group of boroughs whose population is 60% African American (AA). These boroughs, comprising the 15104 ZIP code, are within the study area of MYHAT (R01AG023651), an ongoing population- based cohort study of cognitive impairment and dementia in 2000+ randomly selected seniors in southwestern PA. By using the MYHAT assessment protocol in the proposed new 15104 volunteer cohort, we will collect identical data and cost-effectively leverage the MYHAT data by pooling the two cohorts for analysis. Using appropriate sampling weights to adjust our estimates for non-random sample selection of the 15104 cohort, we will examine risk and resilience factors within the pooled cohort. We will identify factors associated with MCI at baseline, and, through annual follow-up assessments, identify risk factors for subsequent cognitive decline and dementia. Particularly, but not exclusively, we will focus on risk factors common among AA seniors: low education, poor educational quality, low health literacy, APOE*4 genotype, hypertension, diabetes, and smoking. We will then determine whether race modifies the relationship between risk factors and adverse cognitive outcomes. Enhancing the participation of minority seniors will allow us to take a critical first step towards addressing the challenges of investigating, and eventually addressing, cognitive health disparities in the population.