Risk factors for MCI and Dementia in a Diverse Senior Cohort

摘要/总结 不同老年人群MCI和痴呆的危险因素基于社区 关于轻度认知障碍（MCI）和痴呆的研究包括相对较少的纵向研究， 包括低收入少数民族老年人的研究。PAR 15-356特别欢迎项目 该研究建议扩大现有的纵向队列研究，增强多学科研究的力量， 种族队列研究，并探讨阿尔茨海默病（AD）的风险趋势。我们提出 利用密集的社区外展活动，从一个低社会经济地位群体中招募800名老年人， 60%的人口是非洲裔美国人（AA）。这些区，包括 15104邮政编码，在MYHAT（R 01 AG 023651）的研究区域内，这是一个正在进行的种群- 在2000多名随机选择的老年人中进行的基于认知障碍和痴呆的队列研究 西南部的PA。通过在拟定的新15104中使用MYHAT评估方案， 志愿者队列，我们将收集相同的数据，并通过以下方式经济有效地利用MYHAT数据： 将两个队列合并用于分析。使用适当的抽样权重调整我们的 对于15104队列的非随机样本选择的估计，我们将检查风险， 合并队列中的弹性因素。我们将确定与MCI相关的因素， 基线，并通过年度后续评估，确定后续风险因素， 认知能力下降和痴呆。特别是，但不限于此，我们将重点关注风险因素 AA老年人的常见问题：教育程度低，教育质量差，健康素养低， 载脂蛋白E *4基因型与高血压、糖尿病和吸烟的关系然后我们将决定种族 改变了危险因素和不良认知结果之间的关系。增强 少数族裔老年人的参与将使我们能够朝着解决 调查并最终解决认知健康差异的挑战 人口

ABSTRACT/SUMMARY Risk factors for MCI and dementia in a diverse senior cohort. Community-based research on mild cognitive impairment (MCI) and dementia includes relatively few longitudinal studies that include low-income minority seniors. PAR 15-356 specifically welcomes projects that propose augmenting existing longitudinal cohort studies, enhancing the power of multi- ethnic cohort studies, and exploring trends in the risk of Alzheimer's disease (AD). We propose to use intensive community-based outreach to recruit 800 seniors from a low-SES group of boroughs whose population is 60% African American (AA). These boroughs, comprising the 15104 ZIP code, are within the study area of MYHAT (R01AG023651), an ongoing population- based cohort study of cognitive impairment and dementia in 2000+ randomly selected seniors in southwestern PA. By using the MYHAT assessment protocol in the proposed new 15104 volunteer cohort, we will collect identical data and cost-effectively leverage the MYHAT data by pooling the two cohorts for analysis. Using appropriate sampling weights to adjust our estimates for non-random sample selection of the 15104 cohort, we will examine risk and resilience factors within the pooled cohort. We will identify factors associated with MCI at baseline, and, through annual follow-up assessments, identify risk factors for subsequent cognitive decline and dementia. Particularly, but not exclusively, we will focus on risk factors common among AA seniors: low education, poor educational quality, low health literacy, APOE*4 genotype, hypertension, diabetes, and smoking. We will then determine whether race modifies the relationship between risk factors and adverse cognitive outcomes. Enhancing the participation of minority seniors will allow us to take a critical first step towards addressing the challenges of investigating, and eventually addressing, cognitive health disparities in the population.