Mild Cognitive Impairment: A Prospective Community Study

轻度认知障碍：一项前瞻性社区研究

• 批准号: 7666378
• 负责人: MARY GANGULI
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7666378
• 关键词: Activities of Daily Living; Age; Agreement; Alzheimer' s Disease; Apolipoprotein E; Area; Biological; Blood Pressure; Categories; Censuses; Characteristics; Classification; Clinical; Clinical Research; Cognitive; Communities; Condition; Cross-Cultural Comparison; Data; Dementia; Diagnostic; Disease; Early Intervention; Elderly; Epidemiologic Studies; Etiology; Impaired cognition; Impairment; Individual; Intervention; Measures; Mental Depression; Minority; Numbers; Outcome; Participant; Persons; Pharmaceutical Preparations; Phase; Population; Prevalence; Principal Investigator; Public Health; Recruitment Activity; Risk; Sampling; Secondary Prevention; Standards of Weights and Measures; Stroke; Subgroup; Syndrome; Time; Vascular Dementia; aged; cognitive impairment no dementia; cohort; concept; demographics; follow-up; interest; mild neurocognitive impairment; performance tests; programs; prospective

DESCRIPTION (provided by applicant): A substantial number of older adults appear neither cognitively intact nor demented, but have minimal impairments that are intermediate between these two states. The term Cognitive Impairment, No Dementia (CIND) has been used to describe this broad group, regardless of etiology. Subgroups of CIND have been described using several terms, including Mild Cognitive Impairment (MCI) often used to describe a prodromal or risk state for dementing disorders. While clinically useful, these terms, concepts, and criteria are less reliable in the broader community setting, where they seem to identify unstable and heterogeneous categories. Yet, the importance of identifying those with true incipient dementing disorders cannot be overstated, given the growing likelihood of secondary prevention/ early intervention strategies in those most likely to progress to dementia. This revised application is for a new epidemiological project to be carried out near Pittsburgh (PA). Specifically, we will describe the distribution of CIND/ MCI and related entities, their associated features, their outcomes over time, and the predictors of these outcomes. An age-stratified random community sample of approximately 2,100 will be recruited and screened using cognitive, functional, and other health-related measures, to identify the non-demented who are cognitively impaired. Among them, we will identify subgroups meeting operational criteria for MCI of amnestic and other varieties. Participants will be further classified according to multiple, potentially overlapping, schema which are in currently use by different groups. Subgroups will be also characterized with regard to demographic, clinical, and biological variables which may predict outcomes and/or have diagnostic significance. Annual follow-up assessments will track changes in cognitive and functional ability and identify transitions to clinical states including Alzheimer's disease and other dementing disorders. Analysis of these prospectively gathered data will allow subgroups to be defined according to outcome, and thus permit the empirical refinement of clinical and research criteria for various forms of mild cognitive impairment.

描述（由申请人提供）：大量老年人的认知能力既不完整也不痴呆，但具有介于这两种状态之间的轻微损伤。认知障碍，无痴呆 (CIND) 一词已被用来描述这一广泛的群体，无论病因如何。 CIND 的亚组已使用多个术语进行描述，包括轻度认知障碍 (MCI)，通常用于描述痴呆症的前驱或危险状态。虽然在临床上有用，但这些术语、概念和标准在更广泛的社区环境中不太可靠，它们似乎识别不稳定和异质的类别。然而，鉴于对那些最有可能发展为痴呆症的人采取二级预防/早期干预策略的可能性越来越大，识别那些患有真正的早期痴呆症的人的重要性怎么强调也不为过。 此修订后的申请适用于将在匹兹堡（宾夕法尼亚州）附近开展的新流行病学项目。具体来说，我们将描述 CIND/MCI 和相关实体的分布、它们的相关特征、它们随时间的结果以及这些结果的预测因素。将招募约 2,100 名按年龄分层的随机社区样本，并使用认知、功能和其他健康相关措施进行筛选，以确定患有认知障碍的非痴呆人群。其中，我们将确定符合记忆删除和其他品种 MCI 操作标准的亚组。参与者将根据不同群体当前使用的多个可能重叠的模式进一步分类。亚组还将在人口统计学、临床和生物学变量方面进行表征，这些变量可以预测结果和/或具有诊断意义。年度随访评估将跟踪认知和功能能力的变化，并确定向临床状态的转变，包括阿尔茨海默病和其他痴呆症。对这些前瞻性收集的数据的分析将允许根据结果定义亚组，从而允许对各种形式的轻度认知障碍的临床和研究标准进行实证细化。