Pre-doctoral Training Program in Integrative Vascular Biology

综合血管生物学博士前培训项目

• 批准号: 10625918
• 负责人: Christopher P. Mack
• 金额: $ 49.64万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625918
• 关键词: Biology; Blood Vessels; Training Programs; pre-doctoral

Project Summary - The complexity of cardiovascular disease has hindered our understanding of its deveopment and progression. To uncover the mechanisms by which genetic variation and environmental factors influence cardiovascular development and disease, the next generation of scientists will need to be trained to use a variety of approaches, technologies and model systems. In response to this demand, the Integrative Vascular Biology (IVB) Pre-doctoral Training Program was established at UNC in 2002 to promote a collaborative interdisciplinary training environment for pre-doctoral students in the cardiovascular field. The IVB Program combines the breadth and depth of the cardiovascular research faculty with other research strengths at UNC in genetic model systems, state-of-the-art cell biology and imaging, high throughput genomic and proteomic analyses, and computational biology. The overall goal of the IVB Program is to provide Trainees with the interdisciplinary and collaborative skills necessary to extend their thesis work into new, innovative, and productive directions. Specific Aim 1 is to connect Trainees in broad areas of cardiovascular research by requiring them to collaborate with secondary mentors outside of their field. This training mechanism was specifically designed to “connect” graduate students in broad areas of cardiovascular biology and cardiovascular health research. The program teaches students to apply molecular, cellular, genetic, and computational approaches to pathological and physiological questions in cell, organ, and whole animal systems; to merge hypothesis- and discovery-based research; and to develop high-throughput approaches for use in complex models. Specific Aim 2 is to provide Trainees with a broad understanding of cardiovascular development and disease. This will be achieved through advanced paper-based cardiovascular courses, cardiovascular seminars by leaders in the field, and through bi-weekly student-led discussion groups. Specific Aim 3 is to enhance the skills necessary for effective collaboration and career advancement. Trainees will improve their communication skills by presenting their work at formal and informal IVB events and students will attend IVB Workshops on grant writing, career development, and scientific rigor and responsibility. The IVB Program is administered by UNC McAllister Heart Institute and is directed by Dr. Christopher Mack a respected vascular biologist who has been heavily involved in graduate student training at multiple levels. He is assisted by Associate Director, Vicki Bautch, and former IVB director Nobuyo Maeda. The major strength of the Program is the breadth and diversity of the 42 primary training faculty who are committed to graduate student training, extremely well-funded, and using cutting edge approaches to answer a wide-variety of cardiovascular questions. When combined with a well-developed academic program in Cardiovascular Science (also directed by Dr. Mack) and a large pool of well-qualified applicants, the UNC Integrative Vascular Biology Program offers an outstanding environment for multidisciplinary training of pre-doctoral students.

心血管疾病的复杂性阻碍了我们对它的理解。 发展与进步。为了揭示遗传变异和环境变化 影响心血管发育和疾病的因素，下一代科学家将需要 培训使用各种方法、技术和模型系统。为了满足这一需求， 综合血管生物学（IVB）博士前培训计划成立于2002年，以促进 为心血管领域的博士前学生提供跨学科协作培训环境。IVB 该计划结合了心血管研究教师与其他研究优势的广度和深度 在遗传模型系统，国家的最先进的细胞生物学和成像，高通量基因组和 蛋白质组学分析和计算生物学。IVB计划的总体目标是为学员提供 与必要的跨学科和协作技能，以扩展他们的论文工作到新的， 创新和富有成效的方向。具体目标1是在广泛的领域联系学员， 心血管研究，要求他们与他们的领域以外的二级导师合作。这 培训机制是专门设计的"连接"研究生在广泛的领域心血管 生物学和心血管健康研究。该计划教学生应用分子，细胞， 遗传学和计算方法来解决细胞、器官和整体的病理和生理问题 动物系统;合并假设和发现为基础的研究;并开发高通量 用于复杂模型的方法。具体目标2是让学员广泛了解 心血管发育和疾病。这将通过先进的纸质心血管 课程，心血管研讨会的领导人在该领域，并通过双周一次的学生领导的讨论小组。 具体目标3是提高有效合作和职业发展所需的技能。学员 将通过在正式和非正式的IVB活动和学生中展示他们的工作来提高他们的沟通技巧 将参加IVB研讨会的赠款写作，职业发展，科学严谨性和责任。IVB 该计划由McAllister心脏研究所管理，由Christopher Mack博士指导。 受人尊敬的血管生物学家，他一直积极参与多层次的研究生培训。他是 由副主任Vicki Bautch和前IVB主任Nobuyo Maeda协助。的主要优势 该计划是42名致力于毕业的初级培训教师的广度和多样性 学生培训，资金非常充足，并使用尖端的方法来回答各种各样的 心血管问题当与心血管科学的成熟学术课程相结合时 (also由Mack博士指导）和一大批合格的申请人， 该计划为博士前学生的多学科培训提供了良好的环境。

项目成果

SWI/SNF chromatin-remodeling complexes in cardiovascular development and disease.

• DOI: 10.1016/j.carpath.2013.09.003
• 发表时间: 2014-03
• 期刊: CARDIOVASCULAR PATHOLOGY
• 影响因子: 3.7
• 作者: Bevilacqua, Ariana;Willis, Monte S.;Bultman, Scott J.
• 通讯作者: Bultman, Scott J.

Compartmentalized acyl-CoA metabolism in skeletal muscle regulates systemic glucose homeostasis.

• DOI: 10.2337/db13-1070
• 发表时间: 2015-01
• 期刊: Diabetes
• 影响因子: 7.7
• 作者: Li LO;Grevengoed TJ;Paul DS;Ilkayeva O;Koves TR;Pascual F;Newgard CB;Muoio DM;Coleman RA
• 通讯作者: Coleman RA

Microfluidic and Organ-on-a-Chip Approaches to Investigate Cellular and Microenvironmental Contributions to Cardiovascular Function and Pathology.

• DOI: 10.3389/fbioe.2021.624435
• 发表时间: 2021
• 期刊: Frontiers in bioengineering and biotechnology
• 影响因子: 5.7
• 作者: Doherty EL;Aw WY;Hickey AJ;Polacheck WJ
• 通讯作者: Polacheck WJ

Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN.

• DOI: 10.1038/ncb3001
• 发表时间: 2014-08
• 期刊: Nature cell biology
• 影响因子: 21.3

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics.

• DOI: 10.1016/j.actbio.2023.05.015
• 发表时间: 2023-05
• 期刊: Acta biomaterialia
• 影响因子: 9.7
• 作者: Elizabeth L. Doherty;W. Y. Aw;Emily C. Warren;Max A Hockenberry;Chloe P. Whitworth;Grace Krohn;Stefanie Howell;B. Diekman;W. Legant;Hadi T. Nia;Anthony J. Hickey;W. Polacheck