Mentoring Clinical Investigators in Patient Oriented Research on Human Mobility and HIV
指导临床研究人员进行以患者为中心的人类流动性和艾滋病毒研究
基本信息
- 批准号:10257799
- 负责人:
- 金额:$ 13.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-01 至 2026-03-31
- 项目状态:未结题
- 来源:
- 关键词:AIDS preventionAddressAfricaAfrica South of the SaharaAreaAutomobile DrivingBehavioralBudgetsCaliforniaCaringClinicClinical InvestigatorClinical TrialsCohort StudiesCommunitiesComplexDataDemographyDestinationsDevelopmentDevelopment PlansDimensionsDiscipline of obstetricsEastern AfricaElementsEpidemicExposure toFacultyFundingFunding MechanismsGeographic LocationsGeographyGoalsGynecologyHIVHIV riskHIV/STDHealth systemHumanInfrastructureInterventionIntervention StudiesInterviewKenyaKnowledgeLeadLinkLocationLongitudinal StudiesMeasurementMeasuresMedicineMentorsMentorshipMethodsMidcareer Investigator Award in Patient-Oriented ResearchModelingNetwork-basedOutcomePathway AnalysisPatientsPersonsPilot ProjectsPlayPopulationPrevalenceProviderPublic DomainsReproductive SciencesResearchResourcesRoleSan FranciscoScientistSex BehaviorSocial NetworkSorting - Cell MovementTestingTheoretical Domains frameworkTheoretical modelTimeTrainingTreatment outcomeUgandaUniversitiesWomanWorkcare outcomescareercareer developmentcostdesignfeasibility testinggeographic populationimplementation frameworkimprovedmeetingsmenmid-career facultymultidisciplinarynetwork modelsnovelpatient oriented researchpopulation basedpreferenceprogramsprototyperesearch and developmentresearch studysocialtheoriestherapy developmenttransmission process
项目摘要
ABSTRACT
Human mobility plays a substantial role in driving the acquisition and transmission of HIV and
contributing to poor HIV care cascade outcomes. New evidence from large clinical trials shows that mobility
presents a major challenge to the successful implementation of well-recognized HIV eradication strategies
such as universal testing and treatment, as it can link geographically-spread epidemics, lead to introductions of
HIV into communities, reduce exposure to interventions, and disrupt HIV care engagement. There is an urgent
need to better understand the geospatial and temporal dimensions of mobility that lead to disparities in HIV
outcomes, and for feasible and scalable interventions to improve HIV outcomes in mobile populations. Yet,
research in these areas is nascent. There is a great need for an expanded scientific workforce with training in
human mobility and HIV to tackle these challenges, particularly for scientists under-represented in medicine.
Dr. Carol Camlin an Associate Professor in the Department of Obstetrics, Gynecology & Reproductive
Sciences at the University of California, San Francisco, and a behavioral scientist with training in social
demography. Her cross-disciplinary research program has focused on the study of human mobility and HIV
prevention and care outcomes. In this application for the Midcareer Investigator Award in Patient-Oriented
Research (K24), Dr. Camlin proposes a comprehensive mentoring, research and career development plan
which will advance the goal to reduce global disparities in HIV outcomes that result from human mobility.
The overall goals of this proposal are to: 1) Expand the scope of Dr. Camlin's POR in human mobility
and HIV through pursuit of training in geospatial and social network modeling methods, 2) Lay the groundwork
for conducting high-quality, large-scale, theory driven interventions to improve HIV care cascade outcomes
among mobile PLHIV in SSA; and 2) Engage fellows and junior faculty in the development of new
multidisciplinary POR to advance HIV prevention and treatment goals among mobile populations in Africa.
While the K24 provides limited resources for new research, with the support and protected time
provided by the K24, Dr. Camlin will be able to leverage the existing infrastructure of her current studies to: 1)
identify the geospatial networks of mobile populations and HIV “risk flows” in areas of Kenya and Uganda (Aim
1); 2) quantify the `distance decay' between clinics in origins and destinations of highly mobile persons living
with HIV (PLHIV) in the settings, and assess its influence on HIV care engagement (Aim 2); synthesize
cumulative findings and new developments in the field using an implementation science framework, and
convene a multidisciplinary panel of experts to review and prioritize promising interventions; and develop and
evaluate the potential feasibility, acceptability and appropriateness of two prototype strategies to improve HIV
care engagement among mobile PLHIV (Aim 3.) With K24 support, this project lays the groundwork for
sustained high impact research to address the challenges posed by mobility to efforts to eradicate HIV.
摘要
人的流动性在推动艾滋病毒的感染和传播方面发挥着重要作用
造成糟糕的艾滋病毒护理级联结果。来自大型临床试验的新证据表明,移动性
对成功执行公认的艾滋病毒根除战略提出了重大挑战
例如普遍检测和治疗,因为它可以将在地理上传播的流行病联系起来,导致引入
将艾滋病毒带入社区,减少接触干预措施,并扰乱艾滋病毒护理参与。有一件急事
需要更好地了解导致艾滋病毒差异的流动的地理空间和时间维度
为改善流动人口中艾滋病毒感染的结果,提出了可行和可推广的干预措施。然而,
这些领域的研究才刚刚起步。非常需要一支经过培训的科学队伍。
人类流动性和艾滋病毒,以应对这些挑战,特别是对于在医学上代表性不足的科学家。
卡罗尔·卡姆林博士,产科、妇科和生殖学系副教授
加州大学旧金山分校的科学和行为科学家,受过社交方面的培训
人口学。她的跨学科研究计划侧重于人类流动性和艾滋病毒的研究
预防和护理成果。在这份以病人为本的职业生涯中期研究人员奖的申请书中
研究(K24),卡姆林博士提出了一个全面的指导、研究和职业发展计划
这将推进减少因人类流动而导致的艾滋病毒结果的全球差异的目标。
这项提案的总体目标是:1)扩大卡姆林博士的POR在人类流动性方面的范围
通过追求地理空间和社会网络建模方法的培训,2)奠定基础
进行高质量、大规模、理论驱动的干预措施,以改善艾滋病毒护理的级联结果
在SSA的流动PLHIV中;以及2)让研究员和初级教员参与开发新的
在非洲流动人口中推进艾滋病毒预防和治疗目标的多学科POR。
虽然K24为新研究提供了有限的资源,但有支持和保护时间
由K24提供,卡姆林博士将能够利用她目前研究的现有基础设施:1)
查明肯尼亚和乌干达地区流动人口和艾滋病毒“风险流”的地理空间网络(目标
1);2)量化高流动性人群来源地和目的地诊所之间的“距离衰减”
在环境中使用艾滋病毒(艾滋病毒),并评估其对艾滋病毒护理参与的影响(目标2);合成
利用实施科学框架在该领域取得的累积成果和新发展,以及
召集一个多学科专家小组,审查有希望的干预措施并确定其优先次序;
评估改善艾滋病毒的两种原型策略的潜在可行性、可接受性和适当性
流动艾滋病毒感染者之间的护理参与度(目标3)在K24的支持下,该项目为
持续开展影响较大的研究,以应对流动性对根除艾滋病毒工作构成的挑战。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Carol Suzanne Camlin其他文献
Carol Suzanne Camlin的其他文献
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{{ truncateString('Carol Suzanne Camlin', 18)}}的其他基金
Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda
加强行为和社会科学研究能力,应对乌干达艾滋病毒护理和预防方面不断变化的挑战
- 批准号:
10872340 - 财政年份:2023
- 资助金额:
$ 13.42万 - 项目类别:
Mentoring Clinical Investigators in Patient Oriented Research on Human Mobility and HIV
指导临床研究人员进行以患者为中心的人类流动性和艾滋病毒研究
- 批准号:
10597982 - 财政年份:2021
- 资助金额:
$ 13.42万 - 项目类别:
Mentoring Clinical Investigators in Patient Oriented Research on Human Mobility and HIV
指导临床研究人员进行以患者为中心的人类流动性和艾滋病毒研究
- 批准号:
10374173 - 财政年份:2021
- 资助金额:
$ 13.42万 - 项目类别:
Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda
加强行为和社会科学研究能力,应对乌干达艾滋病毒护理和预防方面不断变化的挑战
- 批准号:
10381688 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda
加强行为和社会科学研究能力,应对乌干达艾滋病毒护理和预防方面不断变化的挑战
- 批准号:
10005514 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men
提高男性 ART 和 PrEP 采用率的自测策略和关联激励措施
- 批准号:
10433985 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men
提高男性 ART 和 PrEP 采用率的自测策略和关联激励措施
- 批准号:
10214463 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda
加强行为和社会科学研究能力,应对乌干达艾滋病毒护理和预防方面不断变化的挑战
- 批准号:
9768612 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
Self-Test Strategies and Linkage Incentives to Improve ART and PrEP Uptake in Men
提高男性 ART 和 PrEP 采用率的自测策略和关联激励措施
- 批准号:
10632006 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
Strengthening behavioral and social science research capacity to address the evolving challenges in HIV care and prevention in Uganda
加强行为和社会科学研究能力,应对乌干达艾滋病毒护理和预防方面不断变化的挑战
- 批准号:
10584483 - 财政年份:2019
- 资助金额:
$ 13.42万 - 项目类别:
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