Year 2, Targeted and Clinical Assay Supplement to the NPH MCAC

摘要 精准健康营养(NPH)研究将招募10,000多人来了解个人更多的 饮食模式，以及他们对饮食摄入量的反应。NPH研究的总体目标是开发 预测个体对食物和饮食模式的反应的算法。为促进北卡罗来纳州卫生署的研究目标， NPH代谢和临床分析中心(MCAC)将优先开展一系列NPH联盟 临床分析，靶向和非靶向代谢组学分析，以及使用 从人们的习惯性饮食中收集的生物样本，在3种NPH饮食前后， 以及在流质餐和节食餐之后的特殊膳食挑战。本补充文件准备添加更多 有助于将饮食摄入量和健康之间的关系联系起来的生物标记物分析。 1

Abstract The Nutrition for Precision Health (NPH) study will enroll over 10,000 people to learn more about individuals’ dietary patterns, and their responses to dietary intake. The overall goal of the NPH study is to develop algorithms that predict individual responses to food and dietary patterns. To facilitate the NPH study goal, the NPH Metabolomics and Clinical Assay Center (MCAC) will conduct a range of NPH consortium prioritized clinical assays, targeted and untargeted metabolomics assays, and phytochemical assays using biospecimens collected from people while on their habitual diets, prior to and following each of 3 NPH diets, and following liquid meal and diet specific meal challenges. This supplement is prepared to add additional biomarker assays that will aid in linking the relationship between dietary intake and health. 1