Year 2, Targeted and Clinical Assay Supplement to the NPH MCAC

摘要 精准健康营养 (NPH) 研究将招募超过 10,000 人，以更多地了解个人的健康状况 饮食模式及其对饮食摄入的反应。 NPH 研究的总体目标是开发 预测个人对食物和饮食模式的反应的算法。为了促进 NPH 研究目标， NPH 代谢组学和临床检测中心 (MCAC) 将开展一系列 NPH 联盟优先工作 临床检测、靶向和非靶向代谢组学检测以及植物化学检测 生物样本是在人们习惯饮食时、在 3 种 NPH 饮食之前和之后收集的， 以及遵循流食和饮食特定膳食挑战。本补充准备添加额外的 生物标志物测定有助于将饮食摄入与健康之间的关系联系起来。 1

Abstract The Nutrition for Precision Health (NPH) study will enroll over 10,000 people to learn more about individuals’ dietary patterns, and their responses to dietary intake. The overall goal of the NPH study is to develop algorithms that predict individual responses to food and dietary patterns. To facilitate the NPH study goal, the NPH Metabolomics and Clinical Assay Center (MCAC) will conduct a range of NPH consortium prioritized clinical assays, targeted and untargeted metabolomics assays, and phytochemical assays using biospecimens collected from people while on their habitual diets, prior to and following each of 3 NPH diets, and following liquid meal and diet specific meal challenges. This supplement is prepared to add additional biomarker assays that will aid in linking the relationship between dietary intake and health. 1