Year 2, Targeted and Clinical Assay Supplement to the NPH MCAC

第 2 年，NPH MCAC 的靶向和临床检测补充

• 批准号: 10867046
• 负责人: SUSAN J SUMNER
• 金额: $ 120万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10867046
• 关键词: Aldosterone; Amino Acids; Biogenic Amines; Biological; Biological Assay; Biological Markers; Branched-Chain Amino Acids; Clinical; Diet; Dietary Practices; Dietary intake; Enrollment; Food Patterns; Goals; Health; Individual; Learning; Link; Liquid substance; Measurement; Persons; Phenotype; Phytochemical; Precision Health; Regulation; Renin; Sex Hormone-Binding Globulin; acylcarnitine; cardiovascular health; individual response; metabolomics; precision nutrition; prediction algorithm; response; tool

Abstract The Nutrition for Precision Health (NPH) study will enroll over 10,000 people to learn more about individuals’ dietary patterns, and their responses to dietary intake. The overall goal of the NPH study is to develop algorithms that predict individual responses to food and dietary patterns. To facilitate the NPH study goal, the NPH Metabolomics and Clinical Assay Center (MCAC) will conduct a range of NPH consortium prioritized clinical assays, targeted and untargeted metabolomics assays, and phytochemical assays using biospecimens collected from people while on their habitual diets, prior to and following each of 3 NPH diets, and following liquid meal and diet specific meal challenges. This supplement is prepared to add additional biomarker assays that will aid in linking the relationship between dietary intake and health. 1

摘要 精准健康营养（NPH）研究将招募超过10，000人，以了解更多关于个人健康的信息。 饮食模式，以及他们对饮食摄入的反应。NPH研究的总体目标是开发 预测个体对食物和饮食模式的反应的算法。为了实现NPH研究目标， NPH代谢组学和临床分析中心（MCAC）将进行一系列NPH联盟优先 临床测定、靶向和非靶向代谢组学测定和植物化学测定 在3种NPH饮食之前和之后，从习惯性饮食的人中收集生物标本， 以及在液体膳食和饮食特定膳食挑战之后。本补充材料准备增加额外的 生物标志物测定，这将有助于联系饮食摄入量和健康之间的关系。 1