RTI's Regional Comprehensive Metabolomics Resource Center

描述（由申请人提供）：RTI国际（RTI） RCMRC的目标是发展一个自我维持的区域代谢组学中心，以合理的费用和合作机会提供全面的服务，旨在维护和开发最先进的标准化方法，促进代谢组学的研究、培训和教育，增加训练有素的研究人员的数量，扩大代谢组学技术的使用。RTI RCMRC将与一个联盟合作，建立全国标准，以提供收集和存储在中央数据存储库和协调中心（DRCC）的代谢组学数据的一致性。RTI RCMRC将由RTI领导，其合格和忠诚的高级科学家将为五个核心做出贡献并监督：行政核心A；液相色谱-质谱法代谢组学；气相色谱- ms代谢组学；核磁共振波谱代谢组学；RTI是一个独立的非营利组织，成立于1958年，位于北卡罗来纳州三角研究园（RTP），由北卡罗来纳大学系统、杜克大学和北卡罗来纳商业界共同管理。RTI将促进业务发展活动，以实现增长和可持续性的长期目标。行政核心将监督所有中心活动，并促进RTI和我们的合作者之间的互动。RTI RCMRC是由我们与David H. Murdock研究所以及三位国际公认的代谢组学科学家(dr。杰里米·尼科尔森，伊莱恩·霍姆斯和伊恩·威尔逊)，他们将为这个中心的各个方面提供咨询。这三个技术核心将开发和应用代谢组学方法，以支持协作和基于客户的研究，旨在了解由于暴露（化学物质、药物、环境压力源）、疾病发病、进展、消退或治疗或营养干预而产生的代谢组紊乱。推广和外展核心将开发基于网络的学习工具，增加代谢组学培训项目的实习生人数，并分发宣传材料。

DESCRIPTION (provided by applicant): The goal of the RTI International (RTI) RCMRC is to develop a self-sustaining regional metabolomics center that offers a comprehensive range of services at reasonable fees and collaborative opportunities designed to maintain and develop state-of-the-art standardized methods, and to promote research, training, and education in metabolomics to increase the number of trained investigators and to expand the use of metabolomics technologies. The RTI RCMRC will work in a consortium to establish nationwide standards that will serve to provide consistency in the metabolomics data collected and stored in a central Data Repository and Coordinating Center (DRCC).The RTI RCMRC will be led by RTI, whose qualified and committed senior scientists will contribute to and oversee five Cores: Administrative Core A; Liquid Chromatography-Mass Spectrometry Metabolomics Core B; Gas Chromatography-MS Metabolomics Core C; NMR Spectroscopy Metabolomics Core D; and Promotion and Outreach Core E. RTI is an independent nonprofit, organization, established in 1958 in Research Triangle Park (RTP), North Carolina (NC), and is governed by the University of North Carolina System, by Duke University, and by the NC business community. RTI will facilitate the business development activities to achieve the long-range goals of growth and sustainability. The Administrative Core will provide oversight to all center activities and foster interactions among RTI and our collaborators. The RTI RCMRC is supported by our collaboration with the David H. Murdock Research Institute, and with three internationally recognized metabolomics scientists (Drs. Jeremy Nicholson, Elaine Holmes, and Ian Wilson) who will consult on all aspects of this center. The three technology cores will develop and apply metabolomics methods to support collaborative and client-based studies aimed at understanding perturbations in the metabolome that arise as a result of exposure (to chemicals, drugs, environmental stressors), disease onset, progression, resolution, or therapeutic or nutritional intervention. The Promotion and Outreach Core will develop web-based learning tools, increase the number of interns in the metabolomics training program, and disseminate promotional materials.