RTI's Regional Comprehensive Metabolomics Resource Center

RTI 区域综合代谢组学资源中心

• 批准号: 9327565
• 负责人: SUSAN J SUMNER
• 金额: $ 5万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2016-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9327565
• 关键词: Area; Businesses; Chemicals; Client; Clinical Investigator; Clinical Research; Collaborations; Communities; Consensus; Consult; Contracts; Data; Data Analyses; Data Collection; Data Quality; Data Repository and Coordinating Center; Deposition; Development; Dietary Intervention; Ensure; Exposure to; Feasibility Studies; Fees; Fostering; Funding; Gas Chromatography; Goals; Growth; International; Internships; Laboratories; Lead; Leadership; Learning; Manuscripts; Maps; Mass Fragmentography; Methods; Multivariate Analysis; NMR Spectroscopy; Nonprofit Organizations; North Carolina; Nuclear Magnetic Resonance; Online Systems; Onset of illness; Pathway interactions; Pharmaceutical Preparations; Pilot Projects; Preparation; Publications; Qualifying; Reporting; Research; Research Institute; Research Training; Resolution; Resources; Scientist; Senior Scientist; Services; Statistical Data Interpretation; System; Technology; Therapeutic Intervention; Training Programs; Training and Education; Universities; Work; base; data sharing; design; environmental stressor; investigator training; liquid chromatography mass spectrometry; metabolome; metabolomics; metabolomics resource; new technology; novel strategies; outreach; response; sample collection; tool; web site

DESCRIPTION (provided by applicant): The goal of the RTI International (RTI) RCMRC is to develop a self-sustaining regional metabolomics center that offers a comprehensive range of services at reasonable fees and collaborative opportunities designed to maintain and develop state-of-the-art standardized methods, and to promote research, training, and education in metabolomics to increase the number of trained investigators and to expand the use of metabolomics technologies. The RTI RCMRC will work in a consortium to establish nationwide standards that will serve to provide consistency in the metabolomics data collected and stored in a central Data Repository and Coordinating Center (DRCC).The RTI RCMRC will be led by RTI, whose qualified and committed senior scientists will contribute to and oversee five Cores: Administrative Core A; Liquid Chromatography-Mass Spectrometry Metabolomics Core B; Gas Chromatography-MS Metabolomics Core C; NMR Spectroscopy Metabolomics Core D; and Promotion and Outreach Core E. RTI is an independent nonprofit, organization, established in 1958 in Research Triangle Park (RTP), North Carolina (NC), and is governed by the University of North Carolina System, by Duke University, and by the NC business community. RTI will facilitate the business development activities to achieve the long-range goals of growth and sustainability. The Administrative Core will provide oversight to all center activities and foster interactions among RTI and our collaborators. The RTI RCMRC is supported by our collaboration with the David H. Murdock Research Institute, and with three internationally recognized metabolomics scientists (Drs. Jeremy Nicholson, Elaine Holmes, and Ian Wilson) who will consult on all aspects of this center. The three technology cores will develop and apply metabolomics methods to support collaborative and client-based studies aimed at understanding perturbations in the metabolome that arise as a result of exposure (to chemicals, drugs, environmental stressors), disease onset, progression, resolution, or therapeutic or nutritional intervention. The Promotion and Outreach Core will develop web-based learning tools, increase the number of interns in the metabolomics training program, and disseminate promotional materials.

描述（申请人提供）：RTI国际（RTI）RCMRC的目标是发展一个自我维持的区域代谢组学中心，以合理的费用和合作机会提供全面的服务，旨在维护和发展最先进的标准化方法，并促进研究，培训，和代谢组学教育，以增加训练有素的研究人员的数量，并扩大代谢组学技术的使用。RTI RCMRC将在一个联盟中工作，以建立全国性的标准，这些标准将用于提供收集并存储在中央数据存储库和协调中心（DRCC）中的代谢组学数据的一致性。RTI RCMRC将由RTI领导，其合格和忠诚的高级科学家将贡献并监督五个核心：行政核心A;液相色谱-质谱代谢组学核心B;气相色谱-MS代谢组学核心C; NMR光谱代谢组学核心D;以及推广和推广核心E。RTI是一个独立的非营利组织，成立于1958年在研究三角公园（RTP），北卡罗来纳州（NC），并由北卡罗来纳州系统，由杜克大学，并由NC企业界管理。RTI将促进业务发展活动，以实现增长和可持续发展的长期目标。行政核心将监督所有中心活动，并促进RTI和我们的合作者之间的互动。RTI RCMRC得到了我们与大卫H.默多克研究所，并与三个国际公认的代谢组学科学家（博士杰里米尼科尔森，伊莱恩霍姆斯和伊恩威尔逊）谁将咨询该中心的各个方面。这三个技术核心将开发和应用代谢组学方法，以支持合作和基于客户的研究，旨在了解由于暴露（化学品，药物，环境压力），疾病发作，进展，解决或治疗或营养干预而引起的代谢组学扰动。推广和外联核心将开发基于网络的学习工具，增加代谢组学培训方案的实习生人数，并分发宣传材料。