RTI's Regional Comprehensive Metabolomics Resource Center

RTI 区域综合代谢组学资源中心

• 批准号: 8427473
• 负责人: SUSAN J SUMNER
• 金额: $ 216.34万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-04 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8427473
• 关键词: RTI; Regional; Comprehensive; Metabolomics; Resource

DESCRIPTION (provided by applicant): The goal of the RTI International (RTI) RCMRC is to develop a self-sustaining regional metabolomics center that offers a comprehensive range of services at reasonable fees and collaborative opportunities designed to maintain and develop state-of-the-art standardized methods, and to promote research, training, and education in metabolomics to increase the number of trained investigators and to expand the use of metabolomics technologies. The RTI RCMRC will work in a consortium to establish nationwide standards that will serve to provide consistency in the metabolomics data collected and stored in a central Data Repository and Coordinating Center (DRCC).The RTI RCMRC will be led by RTI, whose qualified and committed senior scientists will contribute to and oversee five Cores: Administrative Core A; Liquid Chromatography-Mass Spectrometry Metabolomics Core B; Gas Chromatography-MS Metabolomics Core C; NMR Spectroscopy Metabolomics Core D; and Promotion and Outreach Core E. RTI is an independent nonprofit, organization, established in 1958 in Research Triangle Park (RTP), North Carolina (NC), and is governed by the University of North Carolina System, by Duke University, and by the NC business community. RTI will facilitate the business development activities to achieve the long-range goals of growth and sustainability. The Administrative Core will provide oversight to all center activities and foster interactions among RTI and our collaborators. The RTI RCMRC is supported by our collaboration with the David H. Murdock Research Institute, and with three internationally recognized metabolomics scientists (Drs. Jeremy Nicholson, Elaine Holmes, and Ian Wilson) who will consult on all aspects of this center. The three technology cores will develop and apply metabolomics methods to support collaborative and client-based studies aimed at understanding perturbations in the metabolome that arise as a result of exposure (to chemicals, drugs, environmental stressors), disease onset, progression, resolution, or therapeutic or nutritional intervention. The Promotion and Outreach Core will develop web-based learning tools, increase the number of interns in the metabolomics training program, and disseminate promotional materials. PUBLIC HEALTH RELEVANCE: This application is prepared in response to RFA-RM-11-016: Regional Comprehensive Metabolomics Resource Cores (RCMRC) (U24), and if funded will be one of several RCMRCs designed to increase the national capacity to provide metabolomics profiling and data analysis services to basic, translational, and clinical investigators.

描述（由申请人提供）：RTI国际（RTI）RCMRC的目标是建立一个自我维持的区域代谢组学中心，以合理的费用提供全面的服务和合作机会，旨在维护和开发最先进的标准化方法，并促进代谢组学的研究、培训和教育，以增加训练有素的研究人员的数量并扩大代谢组学技术的使用。 RTI RCMRC 将与一个联盟合作，制定全国性标准，以确保中央数据存储库和协调中心 (DRCC) 中收集和存储的代谢组学数据的一致性。RTI RCMRC 将由 RTI 领导，RTI 合格且忠诚的资深科学家将致力于并监督五个核心：管理核心 A；液相色谱-质谱代谢组学核心 B；气相色谱-MS 代谢组学 Core C；核磁共振波谱代谢组学核心 D； E.RTI 是一个独立的非营利组织，于 1958 年在北卡罗来纳州研究三角园 (RTP) 成立，由北卡罗来纳大学系统、杜克大学和北卡罗来纳州商业界管理。 RTI 将促进业务发展活动，以实现增长和可持续发展的长期目标。行政核心将对所有中心活动进行监督，并促进 RTI 和我们的合作者之间的互动。 RTI RCMRC 得到了我们与 David H. Murdock 研究所以及三位国际知名代谢组学科学家（Jeremy Nicholson 博士、Elaine Holmes 和 Ian Wilson）的合作支持，他们将就该中心的各个方面提供咨询。这三个技术核心将开发和应用代谢组学方法来支持协作和基于客户的研究，旨在了解由于暴露（化学物质、药物、环境压力源）、疾病发作、进展、消退或治疗或营养干预而产生的代谢组扰动。推广和外展核心将开发基于网络的学习工具，增加代谢组学培训计划的实习生数量，并分发宣传材料。 公共卫生相关性：本申请是根据 RFA-RM-11-016：区域综合代谢组学资源核心 (RCMRC) (U24) 准备的，如果获得资助，将成为旨在提高国家向基础、转化和临床研究人员提供代谢组学分析和数据分析服务的国家能力的多个 RCMRC 之一。