South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE): Increasing Data Science Capacity

南卡罗来纳州 IDeA 生物医学研究卓越网络 (SC INBRE)：提高数据科学能力

• 批准号: 10872026
• 负责人: EDIE C GOLDSMITH
• 金额: $ 36.47万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10872026
• 关键词: Address; Area; Award; Big Data; Biochemistry; Bioinformatics; Biomedical Engineering; Biomedical Research; Cells; Collaborations; Country; Data Science; Development; Educational workshop; Enrollment; Ensure; Extramural Activities; Faculty; Female; Fostering; Funding; Funding Opportunities; Future; Geographic Distribution; Geography; Goals; Growth; Health; Health Personnel; Health Professional; Healthcare; High School Faculty; Historically Black Colleges and Universities; Industry; Institution; Medical; Mentors; Military Personnel; Modeling; Molecular Biology; Neurosciences; Occupations; Paper; Phase; Physicians; Pilot Projects; Population; Presbyterian Church; Publications; Publishing; Regenerative Medicine; Research; Research Infrastructure; Research Project Grants; Research Training; Schools; Scientist; Solid; Source; South Carolina; Students; Teacher Professional Development; Time; Training; Translating; Underrepresented Minority; Universities; Woman; Work; bioinformatics tool; biomedical scientist; career; college; demographics; disadvantaged student; economic disparity; experience; faculty support; graduate school; human disease; inter-institutional; interest; male; member; next generation; outreach; outreach program; personalized medicine; programs; role model; student training; success; training opportunity; undergraduate education; undergraduate research; undergraduate research experience; undergraduate student; underrepresented minority student; underserved area; underserved students; university student

Project Summary The South Carolina IDeA Networks of Biomedical Research Excellence (SC INBRE) is a state-wide network comprised of three Comprehensive Research Universities (CRUs) and ten Primarily Undergraduate Institutions (PUIs) whose goals are to enhance the biomedical research infrastructure and promote undergraduate research training in South Carolina while increasing access to research opportunities and careers in biomedicine for underrepresented minorities and economically disadvantaged students. The scientific themes in SC INBRE emerge from the research expertise in South Carolina and include Biochemistry and Cell/Molecular Biology, Bioengineering, Biomedical Engineering, Regenerative Medicine, and Neuroscience. With the rise of “big data” and a move towards personalized medicine, the need for research and training in Bioinformatics has increased. To meet this demand, the Bioinformatics Core of SC INBRE provides workshops and hands-on training opportunities for faculty and students seeking to apply bioinformatics tools to their research. During the current funding cycle, SC INBRE made significant progress in addressing these goals. From 2015-2019, 415 students were trained in biomedical research labs in the SC INBRE network. Of these students, 39% were male, 61% female and overall 29% were underrepresented minorities. For the students who completed their undergraduate education during this funding period, 44% enrolled in graduate school, 17% went to medical/health professional school, and 39% obtained a job industry. SC INBRE faculty and students produced over 100 publications and gave over 600 presentations during this funding cycle. Their work led to over $9 million dollars in extramural funding from a variety of federal and non-federal sources. Fostering inter-institutional collaborations and promoting a research culture at PUIs, SC INBRE contributed to a collaborative U54 award which brings $12.5 million in research dollars to South Carolina. During the next phase of SC INBRE, the network’s reach across the state will be expanded to include several new PUIs, with long-time network members serving a role models for these new institutions. The Developmental Research Project and Bioinformatics Pilot Project programs will continue to support faculty-driven research and student training. SC INBRE will continue to promote undergraduate research training at network PUIs through SC INRBE-sponsored Undergraduate Research Programs and proposes to expand training capacity at five PUIs through renovation of existing space/facilities. Career and professional development activities will be provided to SC INBRE faculty and students, as well as opportunities to network and develop collaborations with SC INBRE colleagues. Outreach programs developed at selected SC INBRE institutions will engage high school teachers and students, strengthening the pipeline of future college students interested in biomedical research careers and actively encouraging participation by underrepresented minority students and those from underserved areas in South Carolina.

项目概要 南卡罗来纳州 IDeA 生物医学研究卓越网络 (SC INBRE) 是一个全州网络 由三所综合研究型大学 (CRU) 和十所本科院校组成 （PUI），其目标是加强生物医学研究基础设施并促进本科生 南卡罗来纳州的研究培训，同时增加在南卡罗来纳州获得研究机会和职业的机会 为代表性不足的少数群体和经济困难的学生提供生物医学。科学主题 SC INBRE 博士源于南卡罗来纳州的研究专业知识，包括生物化学和 细胞/分子生物学、生物工程、生物医学工程、再生医学和神经科学。 随着“大数据”的兴起和个性化医疗的发展，对研究和培训的需求 生物信息学有所增加。为了满足这一需求，SC INBRE 的生物信息学核心提供了研讨会 为寻求将生物信息学工具应用到他们的工作中的教师和学生提供实践培训机会 研究。在当前的资助周期中，SC INBRE 在实现这些目标方面取得了重大进展。 2015年至2019年，415名学生在SC INBRE网络的生物医学研究实验室接受了培训。其中 学生中，39% 为男性，61% 为女性，总体 29% 为代表性不足的少数族裔。对于学生来说 在此资助期间完成本科教育的人中，44% 就读于研究生院， 17%进入医疗/保健专业学校，39%找到工作行业。 SC INBRE 教师和 在此资助周期内，学生们发表了 100 多份出版物并进行了 600 多场演讲。他们的工作 从各种联邦和非联邦来源获得了超过 900 万美元的外部资金。寄养 SC INBRE 致力于跨机构合作并促进 PUI 的研究文化，为 U54 合作奖为南卡罗来纳州带来了 1250 万美元的研究资金。在接下来的时间里 SC INBRE 阶段，该网络在全州的覆盖范围将扩大到包括几个新的 PUI，其中 长期网络成员为这些新机构树立了榜样。发展研究 项目和生物信息学试点项目计划将继续支持教师驱动的研究和学生 训练。 SC INBRE 将继续通过 SC 促进网络 PUI 的本科生研究培训 INRBE 资助的本科生研究项目并提议扩大五个 PUI 的培训能力 通过改造现有空间/设施。将提供职业和专业发展活动 向 SC INBRE 教职员工和学生提供机会，以及与 SC 建立联系和发展合作的机会 因布雷同事们。选定的 SC INBRE 机构制定的外展计划将吸引高中参与 教师和学生，加强对生物医学研究感兴趣的未来大学生的管道 职业生涯并积极鼓励代表性不足的少数族裔学生和来自其他国家的学生参与 南卡罗来纳州服务不足的地区。

项目成果

Rogue taxa phenomenon: a biological companion to simulation analysis.

• DOI: 10.1016/j.ympev.2013.05.010
• 发表时间: 2013-10
• 期刊: MOLECULAR PHYLOGENETICS AND EVOLUTION
• 影响因子: 4.1
• 作者: Westover, Kristi M.;Rusinko, Joseph P.;Hoin, Jon;Neal, Matthew
• 通讯作者: Neal, Matthew

The neuropeptide galanin adopts an irregular secondary structure.

• DOI: 10.1016/j.bbrc.2022.08.032
• 发表时间: 2022-08
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Rachel E. Wilkinson;Katelyn N. Kraichely;Cecilia M Hendy;Lauren E. Buchanan;S. Parnham;Michael W. Giuliano

Recent advances and limitations in the application of kahalalides for the control of cancer.

• DOI: 10.1016/j.biopha.2022.112676
• 发表时间: 2022-04
• 期刊: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

The Use of Flow Cytometry to Assess the State of Chromatin in T Cells.

• DOI: 10.3791/53533
• 发表时间: 2015-12-17
• 期刊: Journal of visualized experiments : JoVE
• 作者: Bingham KN;Lee MD;Rawlings JS
• 通讯作者: Rawlings JS

Triterpenoid dihydro-CDDO-trifluoroethyl amide protects against maladaptive cardiac remodeling and dysfunction in mice: a critical role of Nrf2.

• DOI: 10.1371/journal.pone.0044899
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Xing Y;Niu T;Wang W;Li J;Li S;Janicki JS;Ruiz S;Meyer CJ;Wang XL;Tang D;Zhao Y;Cui T
• 通讯作者: Cui T