Development of a PEM-PET-CT Breast Imaging and Biopsy Device

PEM-PET-CT 乳腺成像和活检设备的开发

• 批准号: 7590070
• 负责人: RAYMOND ROBERT RAYLMAN
• 金额: $ 50.19万
• 依托单位: WEST VIRGINIA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7590070
• 关键词: Address; Adjuvant Chemotherapy; Algorithms; Area; Biopsy; Breast; Breast Fibrocystic Disease; Caring; Characteristics; Clinical; Clinical Research; Complement; Computer Systems; Computer software; Coupled; Data; Detection; Development; Devices; Diagnosis; Diagnostic; Dose; Effectiveness; Elements; Event; Future; Goals; Head; Human; Image; Image Guided Biopsy; Imaging Techniques; Investigation; Lesion; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Mammography; Measures; Medical Imaging; Methodology; Methods; Modality; Modification; Organ; Partner in relationship; Performance; Photons; Physiological Processes; Positioning Attribute; Positron; Positron-Emission Tomography; Process; Protocols documentation; Radial; Radiation; Radioisotopes; Relative (related person); Resolution; Retinal Cone; Risk Factors; Role; Rotation; Running; Scanning; Scheme; Second Look Surgery; Staging; System; Techniques; Testing; Three-Dimensional Imaging; Time; Tissues; Tomography, Computed, Scanners; United States National Institutes of Health; Woman; X-Ray Computed Tomography; attenuation; breast lesion; breast scanner; calcification; cancer diagnosis; cancer therapy; chemotherapy; cone-beam computed tomography; data acquisition; detector; flexibility; image reconstruction; imaging modality; improved; interest; malignant breast neoplasm; minimally invasive; new technology; public health relevance; radiation absorbed dose; radiotracer; reconstruction; software development; tomography; trend; trial comparing; tumor; whole body imaging

DESCRIPTION (provided by applicant): Positron emission tomography (PET) breast imaging can potentially improve the detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. Additionally, the quantitative capabilities afforded by PET may also be exploited to provide early and accurate assessment of cancer treatment. During the last four years, our group, with the support of the National Institutes of Health, have developed a high-resolution positron emission mammography and tomography imaging and biopsy device (called PEM-PET) to detect and guide the biopsy of suspicious breast lesions, and quantify radionuclide concentrations in tissue. The system consists of two sets of rotating planar detector heads. Each detector head consists of a 4x3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96W72 array of 2W2W15mm3 LYSO detector elements (pitch= 2.1mm). Image reconstruction is performed with a 3D-OSEM algorithm optimized to run on an eight CPU computer system, significantly reducing image reconstruction times. Initial testing of the device is focusing yielded a spatial resolution at the center of the FOV of 1.87mm (radial), 1.84mm (tangential) and 1.67mm (axial); at 7cm from the center, the results were 1.9mm (radial), 1.89mm (tangential) and 1.69mm (axial). Total system detection sensitivity is 363.3kcps/microcurie/ml. In the continuing development of our breast imaging and biopsy system we propose the further optimization of the PET system; addressing some areas of weakness (count rate performance, for example) identified in our initial testing regime. We also propose the addition of a cone beam, x-ray computed tomography (CT) scanner to the current PEM-PET system, creating the PEM-PET-CT breast imaging and biopsy device. PEM-PET-CT will have the unique ability to continuously rotate during data acquisition, permitting the ability to rapidly produce PET and CT images. The anatomical information gained by integration of the CT imager will permit the correlation of structural features of the breast and abnormal areas with functional information from these areas. Thus, the two methods complement each other well. The data provided by the CT images will also be used improve corrections for physical phenomena that can confound quantitative measures of radiotracer concentrations. Finally, the completed system be tested in these two application during a pilot human trial, comparing its performance to whole body PET, MRI and MRS. The data from these studies will be crucial in the planning of future larger human trials. We envision that PEM-PET-CT could be used to detect lesions in women with dense breasts and indeterminate mammograms that have additional risks factors for cancer. It could also be used in the diagnostic role as a "second look" method to assess suspicious lesions or micro- calcifications. Lastly, the unique quantitative capabilities of the system could facilitate its use in treatment assessment of chemotherapy, especially in small tumors. Thus, the development of this new multi-modality system is a unique opportunity to improve a number of important clinical aspects of breast care. PUBLIC HEALTH RELEVANCE This application proposes the continued development of a dedicated breast PET-CT system. This device could be instrumental in the detection, diagnosis and treatment assessment of breast cancer.

描述（由申请人提供）：正电子发射断层扫描（PET）乳房成像可能会改善放射性和/或纤维囊性乳房的癌症的检测和诊断。此外，还可以利用PET提供的定量功能来对癌症治疗进行早期和准确的评估。在过去的四年中，在美国国家卫生研究院的支持下，我们的小组开发了高分辨率的正电子发射乳房X线摄影和层析成像和活检装置（称为PEM-PET），以检测和指导可疑乳房病变的活检，并量化组织中的放射性核素浓度。该系统由两组旋转的平面检测器头组成。每个检测器头由一个4x3阵列Hamamatsu H8500平板位置敏感光电层流（PSPMTS）组成，该光电倍增管（PSPMTS）与96W72阵列为2W2W15MM3 LYSO探测器元件（PITCH = 2.1mm）。图像重建是通过优化在八个CPU计算机系统上运行的3D OSEM算法执行的，从而大大减少了图像重建时间。该设备的初始测试是在1.87mm（radial），1.84mm（切向）和1.67mm（轴向）的FOV中心产生的空间分辨率；距中心7厘米时，结果为1.9mm（径向），1.89mm（切向）和1.69mm（轴向）。总系统检测灵敏度为363.3kcps/microcurie/ml。在乳房成像和活检系统的持续发展中，我们提出了对宠物系统的进一步优化。解决我们初始测试方案中确定的一些弱点（例如计数率表现）的领域。我们还建议在当前的PEM-PET系统中添加锥形束，X射线计算机断层扫描仪（CT）扫描仪，从而创建PEM-PET-CT-CT乳房成像和活检设备。 PEM-PET-CT将具有在数据采集期间连续旋转的独特能力，从而允许快速生产PET和CT图像的能力。通过整合CT成像仪获得的解剖学信息将允许乳房和异常区域的结构特征与这些区域的功能信息相关。因此，这两种方法相互补充。 CT图像提供的数据还将用于改善物理现象的校正，该现象可以混淆放射性示意剂浓度的定量测量。最后，在试验人类试验期间，在这两个应用中测试了完整的系统，将其性能与全身宠物，MRI和MRS进行了比较。这些研究的数据对于未来大型人类试验的计划至关重要。我们设想PEM-PET-CT可用于检测乳房密集的妇女和不确定的乳房X线照片的病变，这些乳房X线照片具有癌症的其他风险因素。它也可以在诊断角色中用作评估可疑病变或微钙化的“第二种外观”方法。最后，该系统的独特定量能力可以促进其在化学疗法的治疗评估中的使用，尤其是在小肿瘤中。因此，这种新的多模式系统的发展是改善乳房护理的许多重要临床方面的独特机会。公共卫生相关性本申请提出了持续开发专门的母乳喂养系统。该设备可能对乳腺癌的检测，诊断和治疗评估有用。