Development of a PEM-PET-CT Breast Imaging and Biopsy Device
PEM-PET-CT 乳腺成像和活检设备的开发
基本信息
- 批准号:7590070
- 负责人:
- 金额:$ 50.19万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-09-01 至 2013-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAdjuvant ChemotherapyAlgorithmsAreaBiopsyBreastBreast Fibrocystic DiseaseCaringCharacteristicsClinicalClinical ResearchComplementComputer SystemsComputer softwareCoupledDataDetectionDevelopmentDevicesDiagnosisDiagnosticDoseEffectivenessElementsEventFutureGoalsHeadHumanImageImage Guided BiopsyImaging TechniquesInvestigationLesionMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalignant NeoplasmsMammographyMeasuresMedical ImagingMethodologyMethodsModalityModificationOrganPartner in relationshipPerformancePhotonsPhysiological ProcessesPositioning AttributePositronPositron-Emission TomographyProcessProtocols documentationRadialRadiationRadioisotopesRelative (related person)ResolutionRetinal ConeRisk FactorsRoleRotationRunningScanningSchemeSecond Look SurgeryStagingSystemTechniquesTestingThree-Dimensional ImagingTimeTissuesTomography, Computed, ScannersUnited States National Institutes of HealthWomanX-Ray Computed Tomographyattenuationbreast lesionbreast scannercalcificationcancer diagnosiscancer therapychemotherapycone-beam computed tomographydata acquisitiondetectorflexibilityimage reconstructionimaging modalityimprovedinterestmalignant breast neoplasmminimally invasivenew technologypublic health relevanceradiation absorbed doseradiotracerreconstructionsoftware developmenttomographytrendtrial comparingtumorwhole body imaging
项目摘要
DESCRIPTION (provided by applicant): Positron emission tomography (PET) breast imaging can potentially improve the detection and diagnosis of cancer in women with radiodense and/or fibrocystic breasts. Additionally, the quantitative capabilities afforded by PET may also be exploited to provide early and accurate assessment of cancer treatment. During the last four years, our group, with the support of the National Institutes of Health, have developed a high-resolution positron emission mammography and tomography imaging and biopsy device (called PEM-PET) to detect and guide the biopsy of suspicious breast lesions, and quantify radionuclide concentrations in tissue. The system consists of two sets of rotating planar detector heads. Each detector head consists of a 4x3 array of Hamamatsu H8500 flat panel position sensitive photomultipliers (PSPMTs) coupled to a 96W72 array of 2W2W15mm3 LYSO detector elements (pitch= 2.1mm). Image reconstruction is performed with a 3D-OSEM algorithm optimized to run on an eight CPU computer system, significantly reducing image reconstruction times. Initial testing of the device is focusing yielded a spatial resolution at the center of the FOV of 1.87mm (radial), 1.84mm (tangential) and 1.67mm (axial); at 7cm from the center, the results were 1.9mm (radial), 1.89mm (tangential) and 1.69mm (axial). Total system detection sensitivity is 363.3kcps/microcurie/ml. In the continuing development of our breast imaging and biopsy system we propose the further optimization of the PET system; addressing some areas of weakness (count rate performance, for example) identified in our initial testing regime. We also propose the addition of a cone beam, x-ray computed tomography (CT) scanner to the current PEM-PET system, creating the PEM-PET-CT breast imaging and biopsy device. PEM-PET-CT will have the unique ability to continuously rotate during data acquisition, permitting the ability to rapidly produce PET and CT images. The anatomical information gained by integration of the CT imager will permit the correlation of structural features of the breast and abnormal areas with functional information from these areas. Thus, the two methods complement each other well. The data provided by the CT images will also be used improve corrections for physical phenomena that can confound quantitative measures of radiotracer concentrations. Finally, the completed system be tested in these two application during a pilot human trial, comparing its performance to whole body PET, MRI and MRS. The data from these studies will be crucial in the planning of future larger human trials. We envision that PEM-PET-CT could be used to detect lesions in women with dense breasts and indeterminate mammograms that have additional risks factors for cancer. It could also be used in the diagnostic role as a "second look" method to assess suspicious lesions or micro- calcifications. Lastly, the unique quantitative capabilities of the system could facilitate its use in treatment assessment of chemotherapy, especially in small tumors. Thus, the development of this new multi-modality system is a unique opportunity to improve a number of important clinical aspects of breast care. PUBLIC HEALTH RELEVANCE This application proposes the continued development of a dedicated breast PET-CT system. This device could be instrumental in the detection, diagnosis and treatment assessment of breast cancer.
描述(由申请人提供):正电子发射断层扫描(PET)乳腺成像可能改善放射性致密和/或纤维囊性乳腺女性的癌症检测和诊断。此外,PET提供的定量能力也可用于提供癌症治疗的早期和准确评估。在过去的四年中,我们的团队在美国国立卫生研究院的支持下,开发了一种高分辨率正电子发射乳腺X射线摄影和断层扫描成像和活检设备(称为PEM-PET),以检测和指导可疑乳腺病变的活检,并量化组织中的放射性核素浓度。该系统由两套旋转平面探测器头组成。每个探测器头由一个4x 3阵列的Hamamatsu H8500平板位置敏感光电倍增管(PSPMT)组成,该光电倍增管耦合到一个96 W72阵列的2 W2 W15 mm 3 LYSO探测器元件(间距= 2.1mm)。图像重建与3D-OSEM算法优化运行在一个八CPU的计算机系统,显着减少图像重建时间。器械的初始测试聚焦在FOV中心处产生的空间分辨率为1.87 mm(径向)、1.84 mm(切向)和1.67 mm(轴向);在距离中心7 cm处,结果为1.9 mm(径向)、1.89 mm(切向)和1.69 mm(轴向)。系统总的检测灵敏度为363.3kcps/μ curie/ml。在我们的乳腺成像和活检系统的持续发展中,我们建议进一步优化PET系统;解决在我们的初始测试制度中发现的一些薄弱领域(例如计数率性能)。我们还建议在当前PEM-PET系统中添加锥形束X射线计算机断层扫描(CT)扫描仪,从而创建PEM-PET-CT乳腺成像和活检设备。PEM-PET-CT将具有在数据采集期间连续旋转的独特能力,从而能够快速生成PET和CT图像。通过整合CT成像仪获得的解剖信息将允许乳房和异常区域的结构特征与来自这些区域的功能信息相关联。因此,这两种方法可以很好地相互补充。CT图像提供的数据也将用于改进对可能混淆放射性示踪剂浓度定量测量的物理现象的校正。最后,完成的系统将在这两个应用程序中进行测试,在试点人体试验期间,将其性能与全身PET,MRI和MRS进行比较。我们设想PEM-PET-CT可用于检测具有致密乳房和不确定乳房X线照片的女性的病变,这些乳房X线照片具有额外的癌症风险因素。它也可以作为一种“第二次检查”方法用于诊断,以评估可疑病变或微钙化。最后,该系统独特的定量能力可以促进其在化疗治疗评估中的使用,特别是在小肿瘤中。因此,这种新的多模态系统的开发是一个独特的机会,以改善乳房护理的一些重要的临床方面。公共卫生相关性本申请建议继续开发专用乳腺PET-CT系统。该设备可用于乳腺癌的检测、诊断和治疗评估。
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
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RAYMOND ROBERT RAYLMAN其他文献
RAYMOND ROBERT RAYLMAN的其他文献
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{{ truncateString('RAYMOND ROBERT RAYLMAN', 18)}}的其他基金
A PET/CT scanner for guiding treatment of head and neck cancer
用于指导头颈癌治疗的 PET/CT 扫描仪
- 批准号:
10161756 - 财政年份:2020
- 资助金额:
$ 50.19万 - 项目类别:
A PET/CT scanner for guiding treatment of head and neck cancer
用于指导头颈癌治疗的 PET/CT 扫描仪
- 批准号:
10390411 - 财政年份:2020
- 资助金额:
$ 50.19万 - 项目类别:
A PET/CT scanner for guiding treatment of head and neck cancer
用于指导头颈癌治疗的 PET/CT 扫描仪
- 批准号:
10619509 - 财政年份:2020
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Development of a Combined MRI-PET System for Contemporaneous Functional Imaging
开发用于同步功能成像的 MRI-PET 组合系统
- 批准号:
7730090 - 财政年份:2009
- 资助金额:
$ 50.19万 - 项目类别:
Development of a Combined MRI-PET System for Contemporaneous Functional Imaging
开发用于同步功能成像的 MRI-PET 组合系统
- 批准号:
7915244 - 财政年份:2009
- 资助金额:
$ 50.19万 - 项目类别:
Development of a Combined MRI-PET System for Contemporaneous Functional Imaging
开发用于同步功能成像的 MRI-PET 组合系统
- 批准号:
8096561 - 财政年份:2009
- 资助金额:
$ 50.19万 - 项目类别:
Development of a Combined MRI-PET System for Contemporaneous Functional Imaging
开发用于同步功能成像的 MRI-PET 组合系统
- 批准号:
8286966 - 财政年份:2009
- 资助金额:
$ 50.19万 - 项目类别:
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