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Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens

Preclinical Evaluation Of Neutralizing Antibodies Elicited by HIV-1 Immunogens
HIV-1 免疫原引发的中和抗体的临床前评估
批准号：
7732735
负责人：
John R Mascola
金额：
$32.02万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7732735
关键词：
AdenovirusesAnimalsAntibodiesAntibody FormationAntigensDNAEvaluationHIV-1ImmunizationLeadMacaca mulattaProteinsRecombinantsTestingTreatment ProtocolsVaccinesVirusdesignneutralizing antibodynovelnovel vaccinesplasmid DNApre-clinical

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英文摘要
The present studies examine the breadth and magnitude of neutralizing antibody (NAb) responses in small animals and rhesus monkeys after various immunization regimens. Using a standardized multi-tier panel of reference Env pseudoviruses for NAb assessment, we show that both protein immunization, and DNA prime, rAd boost immunization, can generate high antibody titers. The potency and breadth of neutralization of primary viruses is still limited. Ongoing optimization of immunogen design will lead to new vaccines to test.
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