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Macaque studies of correlates of HIV protection

Macaque studies of correlates of HIV protection
HIV 保护相关性的猕猴研究
批准号：
7174910
负责人：
John R Mascola
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/7174910
关键词：
AIDS education /preventionAIDS vaccinesMacaca mulattaantiviral antibodycellular immunitycytotoxic T lymphocyteenzyme linked immunosorbent assayhuman immunodeficiency virus 1human tissuehumoral immunityimmunomodulatorsinterleukin 2neutralizing antibodynonhuman therapy evaluationpassive immunizationvaccine developmentvaccine evaluationvector vaccine

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英文摘要
Current HIV vaccine candidates elicit reasonably potent cellular immune responses, but only low levels of neutralizing antibodies. Such CTL based vaccines (e.g., those based on DNA immunization) do not prevent infection, but can have a beneficial effect on disease course. In contrast, passively infused antibodies can provide complete protection, but must be administered in doses that result in serum antibody levels much higher than can be generated by current immunization strategies. We are studying the effect of passively transferred neutralizing antibodies alone, or in combination with active cellular immunity inducted by vaccination.
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PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
PASSIVE ANTIBODY PROTECTION IN SHIV CHALLENGE MODEL
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