Evaluation Of Neutralizing Antibodies Elicited by HIV-1

HIV-1 引起的中和抗体的评估

• 批准号: 7174913
• 负责人: John R Mascola
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7174913
• 关键词: AIDS education /prevention; AIDS vaccines; Animalia; flow cytometry; human immunodeficiency virus 1; immunization; immunogenetics; neutralizing antibody; tissue /cell culture; vaccine development; vaccine evaluation; virus antigen

Several ongoing small animal studies are evaluating the DNA prime, rAd boost vaccine strategy. Preliminary data show that DNA immunization can elicit cellular and humoral immune responses that are substantially boosted by rAd immunization.

几项正在进行的小动物研究正在评估DNA引物、rAd增强疫苗策略。初步数据表明，DNA免疫可引起细胞和体液免疫反应，rAd免疫可显著增强细胞和体液免疫反应。