Non-human Primate Immunogenicity Studies Of Dna Prime, R

DNA Prime、R 的非人类灵长类动物免疫原性研究

• 批准号: 6684228
• 负责人: John R Mascola
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6684228
• 关键词: AIDS vaccines; Adenoviridae; Macaca; active immunization; cellular immunity; humoral immunity; nonhuman therapy evaluation; recombinant virus; transfection /expression vector; vaccine development; vector vaccine

Several ongoing macaque studies are evaluating the DNA prime, rAd boost vaccine strategy. Preliminary data show that DNA immunization can elicit cellular and humoral immune responses that are substantially boosted by rAd immunization.

几项正在进行的猕猴研究正在评估DNA初免，rAd加强疫苗策略。初步数据表明，DNA免疫可以引起细胞和体液免疫应答，这些应答基本上由rAd免疫增强。