Dermatoscopy in the Evaluation of Pigmented Lesions

这个项目的范围仅限于描述常见的、获得性黑素细胞痣和罕见遗传性疾病色素性干皮病患者的各种类型的色素病变的视觉特征。在临床方案06-C-0060 （Thomas J. Hornyak， M.D, Ph.D.，首席研究员）的支持下，患者被招募到皮肤科诊所进行黑素细胞痣的研究和组织获取。选择病变成像与数字脱毛显微镜使用设备，数字皮肤镜，允许评估这些病变在照明放大。这种技术可以观察到与良性或恶性色素病变相关的某些结构。随着时间的推移，我们收集病变的图像，并分析它们的变化和新结构的存在，这些结构可以与特定类型或组织病理学上的细胞排列相关。此外，与博士合作。Kenneth Kraemer和John Digiovanna，我们获得了大约20例色素性干皮病患者的活组织检查色素性皮肤病变的数字皮肤镜图像。这些患者在美国国立卫生研究院临床中心的主持下，Kraemer博士的临床协议集中在色素性干皮病。目前，正在使用标准的皮镜标准，对从这些患者那里获得信息的20多个病变进行分析，以确定它们在临床上是否可以被分类为恶性或良性。此外，对着色性干皮病患者的家庭成员所选择的色素病变的皮镜评估有时也会进行。

The scope of this project is limited to describing visual characteristics corresponding to various types of pigmented lesions in common, acquired melanocytic nevi and in patients with the rare genetic disease xeroderma pigmentosum. Under the auspices of clinical protocol 06-C-0060 (Thomas J. Hornyak, M.D., Ph.D., Principal Investigator), patients are recruited to the Dermatology Clinic for study and tissue acquisition of melanocytic nevi. Selected lesions are imaged with digital epiluminescent microscopy using a device, the digital dermatoscope, that permits evaluation of these lesions under illuminated magnification. Certain structures correlated with benign or malignant pigmented lesions can be observed with this technique. We collect images of lesions over time and analyze them for changes and for the presence of novel structures that can be correlated with specific types or arrangements of cells histopathologically. Also, in collaboration with Drs. Kenneth Kraemer and John Digiovanna, we have obtained digital dermatoscopic images of biopsied pigmented skin lesions on approximately 20 patients with xeroderma pigmentosum. These patients have been seen at the NIH Clinical Center under the auspices of Dr. Kraemer's clinical protocol focused upon xeroderma pigmentosum. Currently the greater than twenty lesions whose information has been obtained from these patients are being analyzed, using standard dermatoscopic criteria, for features that may permit whether they can be classified clinically as malignant or benign. In addition, dermatoscopic evaluation of selected pigmented lesions on family members of those affected with xeroderma pigmentosum is sometimes performed.