Maternal Effect Genes in Mammalian Embryogenesis
哺乳动物胚胎发生中的母体效应基因
基本信息
- 批准号:7733967
- 负责人:
- 金额:$ 88.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:AffectAnimal ModelAreaBindingCell LineageCell divisionCellsComplexDevelopmentEmbryoEmbryonic DevelopmentFemaleGenesGenomeGerm CellsGrowthHumanInner Cell MassInvestigationMeiosisMorulaMusMutationOocytesOvulationProteinsRecurrenceResearch DesignStagingSterilityTranscriptblastocystblastomere structureeggembryo stage 2implantationnovelzygote
项目摘要
We have identified a subcortical maternal complex (SCMC) that assembles during oocyte growth and is essential for zygotes to progress beyond the first embryonic cell divisions. At least four maternally encoded proteins contribute to this MDa complex: FLOPED, MATER and TLE6 interact with each other while Filia binds independently to MATER. Although the transcripts encoding these proteins are degraded during meiotic maturation and ovulation, the SCMC proteins persist in the early embryo. The SCMC, located in the subcortex of eggs, is excluded from regions of cell-cell contact in the cleavage-stage embryo and segregates to the outer cells of the morulae and blastocyst. Floped null and/or Mater null eggs lack the SCMC, but can be fertilized. However, these embryos do not progress beyond cleavage stage development and female mice are sterile. The proteins are conserved in humans and similar maternal effect mutations may result in recurrent embryonic loss.
我们已经确定了一种皮质下母体复合体(SCMC),它在卵母细胞生长过程中组装,对于受精卵在第一次胚胎细胞分裂后的进展是必不可少的。至少有四种母性编码的蛋白质参与了这种丙二醛复合体的形成:FLOPED、MATER和TLE6相互作用,而Filia独立地与MATE结合。虽然编码这些蛋白的转录本在减数分裂成熟和排卵过程中被降解,但SCMC蛋白在早期胚胎中持续存在。SCMC位于卵子的皮质下,被排除在卵裂期胚胎的细胞与细胞接触的区域之外,并与桑椹胚和囊胚的外部细胞分离。无卵和/或无母卵缺乏体细胞,但可以受精。然而,这些胚胎不会超过卵裂阶段的发育,雌性小鼠是不育的。这些蛋白质在人类中是保守的,类似的母系效应突变可能会导致反复的胚胎丢失。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
- DOI:10.1055/s-2007-980218
- 发表时间:2007-07
- 期刊:
- 影响因子:2.7
- 作者:P. Zheng;J. Dean
- 通讯作者:P. Zheng;J. Dean
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JURRIEN DEAN其他文献
JURRIEN DEAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JURRIEN DEAN', 18)}}的其他基金
Molecular Biology of Mammalian Gametogenesis, Fertilization and Early Development
哺乳动物配子发生、受精和早期发育的分子生物学
- 批准号:
10000707 - 财政年份:
- 资助金额:
$ 88.5万 - 项目类别:
Mammalian Gonadogenesis, Folliculogenesis and Fertilization
哺乳动物的性腺发生、卵泡发生和受精
- 批准号:
6105002 - 财政年份:
- 资助金额:
$ 88.5万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 88.5万 - 项目类别:
Grant-in-Aid for Early-Career Scientists