INSOMNIA AND CARDIO-METABOLIC DISEASE RISK IN OLDER ADULTS

老年人的失眠和心脏代谢疾病风险

• 批准号: 7651523
• 负责人: Phyllis C. Zee
• 金额: $ 26.35万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7651523
• 关键词: Adult; Age; Age-Years; Aging; Arts; Blood Glucose; Blood Pressure; Body Temperature; Cardiovascular Diseases; Cardiovascular Physiology; Characteristics; Chicago; Chronic; Chronic Disease; Chronic Insomnia; Circadian Rhythms; Collaborations; Communities; Data; Detection; Development; Disease; Doctor of Philosophy; Dyslipidemias; Elderly; Frequencies; Funding; Gender; Health; Heart; High Prevalence; Hour; Impairment; Individual; Industry; Inflammation; Instruction; Insulin; Insulin Resistance; Link; Logistic Regressions; Maintenance; Measurement; Measures; Medical; Medicine; Melatonin; Metabolic; Metabolic Diseases; Metabolism; Middle Insomnia; Participant; Patient Self-Report; Phase; Phenotype; Play; Population; Population Study; Prevention; Principal Investigator; Program Research Project Grants; Public Health; REM Sleep; Race; Recruitment Activity; Regulation; Reporting; Risk; Risk Factors; Risk Marker; Role; Sampling; Severities; Signal Transduction; Sleep; Sleep Fragmentations; Sleep Stages; Sleep disturbances; Sleeplessness; Slow-Wave Sleep; Symptoms; Time; Woman; Work; age related; base; cardiovascular disorder risk; cardiovascular risk factor; cohort; cost efficient; diabetes risk; disorder risk; improved; indexing; inflammatory marker; insight; interest; older men; programs; stressor

instructions): Chronic sleep disturbance is reported by nearly 50% of older adults. The high prevalence of insomnia in older adults is likely due to an interaction of age-related changes in sleep and circadian regulation, chronic illnesses and late life stressors. Recent evidence suggests that poor health contributes to poor sleep, but poor sleep can also increase the risk for poor health. Evidence from our group shows that sleep loss may promote the development or increase the severity of age-related cardio-metabolic disease. While many studies have confirmed the link between short sleep duration and cardio-metabolic disease, emerging evidence supports a relationship between insomnia symptoms and risk for cardiovascular disease. However, little is known of the impact of insomnia or its specific sleep characteristics on cardio-metabolic health in older adults. In the present study, we propose to examine in detail the relationship between sleep characteristics with cardio-metabolic risk factors in older adults with chronic insomnia. A total of 120 older adults with chronic insomnia and controls will be recruited from the Chicago Heart Association Detection Project in Industry cohort. This collaboration represents a unique and cost efficient opportunity to study the relationship between insomnia and cardio-metabolic risk factors in a large group of community based older adults ages 65-80 years of age. The overall aim of this project is to define the sleep, circadian and cardio- metabolic phenotypes of common age-related insomnia subtypes. Objective and self reported measures of nocturnal sleep, daytime sleepiness, circadian rhythm, metabolism, inflammation, and autonomic function will be assessed in older adults with chronic insomnia and compared to age, gender, race and BMI matched controls without insomnia. The specific aims are: 1) Assess whether levels of cardio-metabolic risk factors are higher in older adults with chronic insomnia than in their counterparts without insomnia; 2) Determine the role of each of the major sleep characteristics: total sleep time, sleep efficiency, latency to persistent sleep, sleep fragmentation, minutes of slow wave sleep, minutes of REM sleep, slow wave activity and high frequency activity, and daytime sleepiness on cardio-metabolic function in older adults with and without chronic insomnia; and 3) Determine the contribution of circadian phase and amplitude to the relationship between insomnia and cardio-metabolic disease risk factors. The results of the proposed study will greatly improve our understanding of the impact of insomnia and the role of specific sleep and wake characteristics on cardio-metabolic disease risk markers and daytime function in older adults. RELEVANCE (See instructions): The proposed study has important implications for public health. If chronic insomnia in older adults is associated with elevated cardio-metabolic risk factors, it would strongly underscore the importance of identifying and treating insomnia in older adults. Furthermore, these results can provide the basis for personalized approaches to the treatment of insomnia as well as the prevention of common age associated co-morbid medical and psychiatric conditions.

指示）： 近50％的老年人报告了慢性睡眠障碍。失眠的高流行率 老年人可能是由于年龄相关的睡眠变化与昼夜节律的相互作用，慢性 疾病和后期的生活压力。最近的证据表明，健康状况不佳会导致睡眠不良，但 睡眠不足也会增加健康状况不佳的风险。我们小组的证据表明睡眠损失可能 促进发展或增加与年龄相关的心脏代谢疾病的严重程度。而很多 研究已经证实了短睡眠时间与心脏代谢疾病之间的联系 证据支持失眠症状与心血管疾病的风险之间的关系。然而， 关于失眠或其特定睡眠特征对心脏代谢健康的影响鲜为人知 老年人。在本研究中，我们建议详细检查睡眠之间的关系 慢性失眠的老年人中有心脏代谢风险因素的特征。总共120岁 慢性失眠和对照组的成年人将从芝加哥心脏协会检测中招募 行业队列项目。这项合作代表了研究 大量基于社区的较老的失眠与心脏代谢风险因素之间的关系 年龄在65-80岁的成年人。该项目的总体目的是定义睡眠，昼夜节律 - 常见年龄相关失眠亚型的代谢表型。客观和自我报告的措施 夜间睡眠，白天嗜睡，昼夜节律，代谢，炎症和自主功能 将在患有慢性失眠的老年人中进行评估，并与年龄，性别，种族和BMI相匹配。 没有失眠的控制。具体目的是：1）评估心脏代谢危险因素的水平是否 在慢性失眠的老年人中，没有失眠的人高。 2）确定 每个主要睡眠特征的作用：总睡眠时间，睡眠效率，持续睡眠的潜伏期， 睡眠碎片，慢波睡眠时间，雷姆睡眠时间，慢波活动和高 在有和没有的老年人中，频率活动和白天嗜睡 慢性失眠； 3）确定昼夜节相和幅度对关系的贡献 失眠和心脏代谢疾病风险因素之间。拟议研究的结果将大大 提高我们对失眠影响以及特定睡眠和唤醒特征的作用的理解 关于心脏代谢疾病的风险标志和白天的功能。 相关性（请参阅说明）： 拟议的研究对公共卫生具有重要意义。如果老年人的慢性失眠是 与升高的心脏代谢风险因素相关，它将强烈强调 识别和治疗老年人失眠。此外，这些结果可以为 个性化治疗失眠以及预防共同年龄相关的方法 合并医学和精神病病。