2009 GRC Muscle: Excitation/Contraction Coupling

描述(申请人提供)：这是戈登会议的部分支持申请，题为肌肉：兴奋/收缩耦合，将于2009年6月14-19日在新罕布夏州沃特维尔山谷举行。这次会议始于1970年，此后每三年举行一次会议，这是唯一一次主要关注骨骼肌兴奋-收缩偶联(ECC)的国内或国际会议。总体目标是增加我们对电刺激和肌肉收缩之间的联系的了解，以及钙在正常肌肉功能和肌肉疾病中的作用。2009年会议的具体目标是召集总共175名与会者，包括9场会议的31名发言者，由会议主席介绍每届会议，促进讨论，并强调争议和重要的未解问题。会议的主题将包括ECC的超微结构和分子基础，ECC过程中钙的运动，导致或导致肌肉疾病和疲劳的钙动力学的变化，以及钙信号在肌肉的发育、生理适应和衰老中的作用。这次会议的意义在于，许多对ECC重要的问题在其他组织中也很重要，而且ECC背后的细胞系统通常参与病理生理状态的发展。这次会议将促进新的研究，因为它汇集了一系列感兴趣的演讲者，从生物物理学和离子通道的结构(最初肌肉和离子通道是单一戈登会议的一部分)，到转录调控，再到作为临床实体的肌肉疾病。这次会议与健康相关的是，遗传性人类骨骼肌和心肌疾病是由ECC相关蛋白质的突变造成的，钙信号对肌肉的使用/废弃反应和损伤后的修复至关重要。

DESCRIPTION (provided by applicant): This is an application for partial support of the Gordon Conference entitled Muscle: Excitation/Contraction Coupling, which will be held at Waterville Valley, New Hampshire, June 14 - 19, 2009. This conference, which is the only national or international meeting with a primary focus on excitation-contraction coupling (ECC) in skeletal muscle, began in 1970 and has met every three years since. The overall goal is to increase our understanding of the link between electrical excitation and contraction of muscle, and of the roles of calcium in normal muscle function and in muscle disease. The specific aims of the 2009 conference are to convene 175 total participants, including 31 speakers in 9 sessions, with session chairs providing an introduction to each session, facilitating discussion, and highlighting controversies and important, unanswered questions. The topics of the sessions will include the ultrastructural and molecular basis for ECC, the movements of calcium during ECC, alterations in calcium dynamics that contribute to, or result from, muscle diseases and fatigue, and the role of calcium signals in the development, physiological adaptation and aging of muscle. The significance of the conference is that many of the issues of importance to ECC are also important in other tissues, and that the cellular systems underlying ECC are oftern involved in the development of pathophysiological states. The conference will foster new research because it brings together a spectrum of speakers with interests ranging from the biophysics and structure of ion channels (originally muscle and ion channels were part of a single Gordon conference), to transcriptional regulation, to muscle diseases as clinical entities. The health relatedness of the conference is that inherited human diseases of skeletal and cardiac muscle result from mutations of the proteins involved in ECC, and that calcium signaling is critical for the response of muscle to use/disuse and for its repair after injury.