2009 GRC Muscle: Excitation/Contraction Coupling

2009 GRC 肌肉：激发/收缩耦合

• 批准号: 7671845
• 负责人: KURT G BEAM
• 金额: $ 1.5万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2009-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7671845
• 关键词: Biological; Biology; Biophysics; Calcium; Calcium Signaling; Clinical; Coupling; Development; Fatigue; Fostering; Funding; Goals; Health; Human; Inherited; Injury; International; Ion Channel; Link; Molecular; Movement; Muscle; Muscle Cells; Muscle Contraction; Muscle function; Mutation; Myocardium; Myopathy; New Hampshire; Participant; Physiological Adaptation; Proteins; Research; Research Personnel; Role; Scientist; Skeletal Muscle; Structure; System; Tissues; Transcriptional Regulation; Work; base; human disease; insight; interest; meetings; muscle aging; repaired; response; skeletal; symposium

DESCRIPTION (provided by applicant): This is an application for partial support of the Gordon Conference entitled Muscle: Excitation/Contraction Coupling, which will be held at Waterville Valley, New Hampshire, June 14 - 19, 2009. This conference, which is the only national or international meeting with a primary focus on excitation-contraction coupling (ECC) in skeletal muscle, began in 1970 and has met every three years since. The overall goal is to increase our understanding of the link between electrical excitation and contraction of muscle, and of the roles of calcium in normal muscle function and in muscle disease. The specific aims of the 2009 conference are to convene 175 total participants, including 31 speakers in 9 sessions, with session chairs providing an introduction to each session, facilitating discussion, and highlighting controversies and important, unanswered questions. The topics of the sessions will include the ultrastructural and molecular basis for ECC, the movements of calcium during ECC, alterations in calcium dynamics that contribute to, or result from, muscle diseases and fatigue, and the role of calcium signals in the development, physiological adaptation and aging of muscle. The significance of the conference is that many of the issues of importance to ECC are also important in other tissues, and that the cellular systems underlying ECC are oftern involved in the development of pathophysiological states. The conference will foster new research because it brings together a spectrum of speakers with interests ranging from the biophysics and structure of ion channels (originally muscle and ion channels were part of a single Gordon conference), to transcriptional regulation, to muscle diseases as clinical entities. The health relatedness of the conference is that inherited human diseases of skeletal and cardiac muscle result from mutations of the proteins involved in ECC, and that calcium signaling is critical for the response of muscle to use/disuse and for its repair after injury.

描述（由申请人提供）：这是一份题为“肌肉：兴奋/收缩耦合”的戈登会议的部分支持申请，该会议将于 2009 年 6 月 14 日至 19 日在新罕布什尔州沃特维尔谷举行。该会议是唯一一次主要关注骨骼肌兴奋-收缩耦合 (ECC) 的国家或国际会议，始于 1970 年，此后每三年举行一次。总体目标是增加我们对电兴奋和肌肉收缩之间的联系以及钙在正常肌肉功能和肌肉疾病中的作用的理解。 2009年会议的具体目标是召集总共175名与会者，其中包括9场会议的31名发言者，会议主席对每场会议进行介绍，促进讨论，​​并强调争议和重要的、未解答的问题。会议主题将包括 ECC 的超微结构和分子基础、ECC 期间钙的运动、导致或导致肌肉疾病和疲劳的钙动力学变化，以及钙信号在肌肉发育、生理适应和衰老中的作用。此次会议的意义在于，许多对 ECC 重要的问题在其他组织中也很重要，并且 ECC 背后的细胞系统通常参与病理生理状态的发展。该会议将促进新的研究，因为它汇集了一系列感兴趣的演讲者，从生物物理学和离子通道结构（最初肌肉和离子通道是单个戈登会议的一部分）到转录调控，再到作为临床实体的肌肉疾病。此次会议的健康相关性在于，人类遗传性骨骼和心肌疾病是由参与 ECC 的蛋白质突变引起的，而钙信号传导对于肌肉使用/废弃的反应以及损伤后的修复至关重要。