Portable photoacoustic microscopy

便携式光声显微镜

• 批准号: 7656172
• 负责人: Jian Liu
• 金额: $ 10.01万
• 依托单位: POLARONYX, INC.
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2009-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7656172
• 关键词: Amplifiers; Animal Experimentation; Animals; Award; Ballistics; Biological; Biotechnology; Blood Vessels; Brain; Cellular biology; Clinic; Collaborations; Confocal Microscopy; Contrast Media; Development; Diagnostic; Fiber; Functional Imaging; Generations; Hemoglobin; Image; Imaging technology; Industry; Investigation; Lasers; Malignant neoplasm of brain; Malignant neoplasm of cervix uteri; Methyl Green; Microscopy; Molecular; Molecular Probes; Morphologic artifacts; Nature; Noise; Optical Coherence Tomography; Optics; Output; Oxygen; Phase; Physiologic pulse; Physiological; Play; Production; Publishing; Pump; Records; Research; Residual state; Resolution; Role; Shapes; Skin Cancer; Small Business Innovation Research Grant; Speed; System; Techniques; Technology; Testing; Time; Tissues; Ultrasonics; Ultrasonography; Universities; Washington; Width; Work; absorption; angiogenesis; base; clinical Diagnosis; clinical application; clinical practice; commercialization; cost; design; drug discovery; imaging modality; in vivo; innovation; lysophosphatidic acid; malignant breast neoplasm; medical specialties; molecular imaging; nanosecond; novel; optical imaging; prototype; public health relevance; second harmonic; two-photon

DESCRIPTION (provided by applicant): This SBIR phase I project proposes a novel all-fiber and ultra compact high power nanosecond fiber laser system by using our proprietary technologies on spectral shaping and pulse shaping. The proposed idea is an enabling technology for portable photoacoustic microscopy. It is a specialty fiber based MOPA. Our unique spectral shaping techniques enable us to reduce the SBS and ASE noise significantly in the amplifier for commercially available YDFs and to reuse the residual pump to further increase the efficiency. These will make the fiber laser system superior in terms of wall plug efficiency (over 20%), power (>10 W and > 100 kW peak power), noise, size, and cost. The cost and size will be at least ten times cheaper than other competing approaches. The design is simpler in construction and easy to operate. In Phase I time frame, a prototype 1064 nm fiber laser operating at output energy of 0.5 mJ will be built up and preliminary test will be done for imaging. Fine tuning of the product to achieve more compact size and generation of second harmonic green light laser and several imaging applications (in collaboration with Washington University) will be given in Phase II with an investigation of volume production. PUBLIC HEALTH RELEVANCE: The proposed portable photoacoustic microscopy provides a breakthrough in applying nanosecond fiber laser technology into real clinic. Though photoacoustic microscopy is our first application in obtaining deep tissue high resolution image, it will have significant impact to other biomedical applications.

描述(申请人提供)：该SBIR一期项目利用我们在频谱整形和脉冲整形方面的专有技术，提出了一种新型的全光纤和超紧凑型高功率纳秒光纤激光系统。提出的想法是使便携式光声显微镜成为可能的技术。它是一种基于MOPA的特种光纤。我们独特的频谱整形技术使我们能够显著降低商用YDF放大器中的SBS和ASE噪声，并重复使用剩余泵浦以进一步提高效率。这将使光纤激光系统在壁塞效率(20%以上)、功率(10W和100kW峰值功率)、噪声、尺寸和成本方面更具优势。成本和规模将至少比其他竞争方法便宜十倍。该设计结构简单，操作方便。在第一阶段的时间框架内，将建立一台输出能量为0.5mJ的1064 nm光纤激光器的样机，并对其进行成像的初步测试。第二阶段将对产品进行微调，以实现更紧凑的尺寸和产生二次谐波绿光激光和几种成像应用(与华盛顿大学合作)，并对批量生产进行调查。公共卫生相关性：拟议的便携式光声显微镜在将纳秒光纤激光技术应用于实际临床方面取得了突破。虽然光声显微镜是我们在获得深部组织高分辨率图像方面的第一个应用，但它将对其他生物医学应用产生重大影响。