Portable photoacoustic microscopy

描述（由申请人提供）：SBIR第一阶段项目提出了一种新型的全光纤和超紧凑型高功率纳秒光纤激光器系统，采用我们的光谱整形和脉冲整形专有技术。所提出的想法是一种使能技术的便携式光声显微镜。它是一种基于特种纤维的MOPA。我们独特的频谱整形技术使我们能够显著降低商用YDF放大器中的SBS和ASE噪声，并重新使用剩余泵浦以进一步提高效率。这些将使光纤激光器系统在壁插效率（超过20%）、功率（>10 W和> 100 kW峰值功率）、噪声、尺寸和成本方面上级。成本和尺寸将比其他竞争方法便宜至少十倍。该设计结构简单，操作方便。在第一阶段的时间框架内，将建立一个原型1064 nm光纤激光器，输出能量为0.5 mJ，并进行初步测试成像。第二阶段将对产品进行微调，以实现更紧凑的尺寸，并产生二次谐波绿色激光和几种成像应用（与华盛顿大学合作），并对批量生产进行调查。公共卫生相关性：提出的便携式光声显微镜提供了一个突破纳秒光纤激光技术应用到真实的临床。虽然光声显微术是我们在获取深部组织高分辨率图像方面的第一个应用，但它将对其他生物医学应用产生重大影响。

DESCRIPTION (provided by applicant): This SBIR phase I project proposes a novel all-fiber and ultra compact high power nanosecond fiber laser system by using our proprietary technologies on spectral shaping and pulse shaping. The proposed idea is an enabling technology for portable photoacoustic microscopy. It is a specialty fiber based MOPA. Our unique spectral shaping techniques enable us to reduce the SBS and ASE noise significantly in the amplifier for commercially available YDFs and to reuse the residual pump to further increase the efficiency. These will make the fiber laser system superior in terms of wall plug efficiency (over 20%), power (>10 W and > 100 kW peak power), noise, size, and cost. The cost and size will be at least ten times cheaper than other competing approaches. The design is simpler in construction and easy to operate. In Phase I time frame, a prototype 1064 nm fiber laser operating at output energy of 0.5 mJ will be built up and preliminary test will be done for imaging. Fine tuning of the product to achieve more compact size and generation of second harmonic green light laser and several imaging applications (in collaboration with Washington University) will be given in Phase II with an investigation of volume production. PUBLIC HEALTH RELEVANCE: The proposed portable photoacoustic microscopy provides a breakthrough in applying nanosecond fiber laser technology into real clinic. Though photoacoustic microscopy is our first application in obtaining deep tissue high resolution image, it will have significant impact to other biomedical applications.