Portable Fiber Lasers for Multiphoton Endoscope

描述（由申请人提供）：将开发一种基于全光纤的多光子内窥镜，用于采集来自组织的体内MPM信号。飞秒光纤激光器和小型光纤探针将使从内腔和器官的小区域检测MPM信号成为可能。 PolarOnyx提议开发一种创新的高功率飞秒光纤激光器，该激光器通过光纤将未失真的飞秒光脉冲传输到组织，并通过光纤束收集从组织激发的MPM信号。使用全光纤组件，该系统将是紧凑，便携和低成本的。在第一阶段，飞秒光纤激光器将被开发和优化用于MPM应用。一个微型探头将被设计为提供激发光和收集信号。激光束将被扫描的深度和多光子光谱将获得使用摄谱仪。在第二阶段，将对激光器进行全面优化，并与光纤探头集成，以实现真实的临床试验。

DESCRIPTION (provided by applicant): An all-fiber-based multiphoton endoscope will be developed for acquiring in vivo MPM signals from tissues. A femtosecond fiber laser and a small fiber probe will make it possible to detect MPM signals from small areas of internal cavities and organs. PolarOnyx proposes to develop an innovative high power femtosecond fiber laser with fiber delivering of undistorted femtosecond light pulses to tissues and a fiber bundle for collecting MPM signals excited from tissues. Using all-fiber-based components, the system will be compact, portable, and low-cost. In phase I, a femtosecond fiber laser will be developed and optimized for MPM applications. A miniature probe head will be designed to deliver excitation light and collect signals. Laser beam will be scanned in depth and multiphoton spectra will be acquired using a spectrograph. In phase II, the laser will be fully optimized and integrate with the fiber probe towards real clinic try.