Portable Fiber Lasers for Multiphoton Endoscope

用于多光子内窥镜的便携式光纤激光器

• 批准号: 7536162
• 负责人: Jian Liu
• 金额: $ 9.96万
• 依托单位: POLARONYX, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7536162
• 关键词: Area; Clinic; Depth; Endoscopes; Fiber; Head; Lasers; Light; Organ; Phase; Physiologic pulse; Pulse taking; Scanning; Signal Transduction; System; Tissues; base; cost; design; in vivo; innovation

DESCRIPTION (provided by applicant): An all-fiber-based multiphoton endoscope will be developed for acquiring in vivo MPM signals from tissues. A femtosecond fiber laser and a small fiber probe will make it possible to detect MPM signals from small areas of internal cavities and organs. PolarOnyx proposes to develop an innovative high power femtosecond fiber laser with fiber delivering of undistorted femtosecond light pulses to tissues and a fiber bundle for collecting MPM signals excited from tissues. Using all-fiber-based components, the system will be compact, portable, and low-cost. In phase I, a femtosecond fiber laser will be developed and optimized for MPM applications. A miniature probe head will be designed to deliver excitation light and collect signals. Laser beam will be scanned in depth and multiphoton spectra will be acquired using a spectrograph. In phase II, the laser will be fully optimized and integrate with the fiber probe towards real clinic try.

描述（由申请人提供）：将开发一种全纤维多光子内窥镜，用于从组织中获取体内MPM信号。一个飞秒光纤激光器和一个小光纤探头将使从内部腔和器官的小区域检测MPM信号成为可能。PolarOnyx提出了一种创新的高功率飞秒光纤激光器，该激光器采用光纤向组织传输未失真的飞秒光脉冲，并采用光纤束收集组织激发的MPM信号。该系统采用全光纤组件，结构紧凑、便携且成本低廉。在第一阶段，将开发并优化用于MPM应用的飞秒光纤激光器。一个微型探头将被设计用来发送激发光和收集信号。利用摄谱仪对激光束进行深度扫描，获取多光子光谱。在第二阶段，将对激光器进行充分优化，并与光纤探头相结合，走向真正的临床试验。