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Efficient snap-shot CT imaging of the entire heart using staggered circular scans

使用交错圆形扫描对整个心脏进行高效快照 CT 成像

基本信息

批准号：
7880625
负责人：
Frederic Noo
金额：
$ 18.62万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7880625
关键词：
Address Advertising Algorithms Angiography Area Body Image Breathing Cardiac Complement Computer Simulation Computers Coronary Coronary artery Data Development Diagnostic Dose Evaluation Freezing Goals Heart Human Image Knowledge Low Dose Radiation Marketing Measurement Morphologic artifacts Motion Noise Patients Performance Plant Roots Relative (related person)Research Proposals Resolution Retinal Cone Rotation Scanning Simulate Solutions Somatotype Source Speed Stenosis System Technology Tomography, Computed, Scanners Translations Validation X-Ray Computed Tomography base comparative coronary computed tomography angiography cost data acquisition design detector heart motion image reconstruction improved indexing innovation interest patient population prevent prototype public health relevance reconstruction simulation theories tomography tool

项目摘要

DESCRIPTION (provided by applicant): We are interested in x-ray computed tomography (CT) imaging of the coronary arteries, commonly referred to as coronary CT angiography (CTA). Specifically, we suggest an innovative, low-cost solution to the problem of performing accurate coronary CTA within a single heartbeat. This solution is the result of combining the latest advances in image reconstruction theory with careful system design considerations. More specifically, we propose to mitigate artifacts occurring with circular CB tomography of the entire heart, using (i) a new concept of scans, called staggered circular scans, that use several x-ray sources together to obtain CB data on parallel circular trajectories for the net effect of reducing the cone angle without requiring axial motion, (ii) innovative reconstruction algorithms that draw on recent advances in image reconstruction theory. Staggered circular scans are defined with an index K that gives the number of x-ray sources involved. We will focus our effort on the following aims: (1) Development, implementation and validation of a preferred reconstruction algorithm for accurate coronary CTA using staggered circular scans of index K = 2, K = 3 and K = 4. (2) Comparative evaluation of staggered circular scans against each other and against the conventional circular data acquisition. (3) Demonstration of robustness for real data. (4) Feasibility demonstration of accurate general body imaging with a scanner designed to perform staggered circular scans. PUBLIC HEALTH RELEVANCE: NARRATIVE This proposal aims at allowing a leap forward in technology so that cardiac CT imaging can be achieved consistently (i.e., independently of the patient heart's condition) with high accuracy, low scanner cost, and a dose comparable to that of a conventional CT scan. The patients will therefore receive a lower radiation dose with an improved diagnostic, and the population of patients that can be imaged will be widened.

描述（由申请人提供）：我们对冠状动脉的X射线计算机断层扫描（CT）成像感兴趣，通常称为冠状动脉CT血管造影（CTA）。具体来说，我们提出了一个创新的，低成本的解决方案，在一个单一的心跳进行准确的冠状动脉CTA的问题。该解决方案是将图像重建理论的最新进展与仔细的系统设计考虑相结合的结果。更具体地，我们提出使用（i）称为交错圆形扫描的扫描的新概念，其一起使用几个X射线源以获得平行圆形轨迹上的CB数据，用于减小锥角而不需要轴向运动的净效果，（ii）利用图像重建理论的最新进展的创新重建算法。交错圆形扫描定义为索引K，该索引K给出所涉及的X射线源的数量。我们将致力于以下目标：（1）开发、实施和验证用于精确冠状动脉CTA的首选重建算法，使用指数K = 2、K = 3和K = 4的交错圆形扫描。(2)交错圆形扫描相互之间以及与传统圆形数据采集的比较评估。(3)真实的数据的稳健性证明。(4)使用设计用于执行交错圆形扫描的扫描仪进行精确全身成像的可行性论证。公共卫生相关性：该提议旨在允许技术上的飞跃，使得可以一致地实现心脏CT成像（即，独立于患者心脏状况），具有高精度、低扫描器成本和与常规CT扫描相当的剂量。因此，患者将接受更低的辐射剂量，并改善诊断，可以成像的患者群体将扩大。