Multifunctional Image Guided Surgical Platform

描述（由申请人提供）：拟议项目的总体目标是开发一种用于执行精细和复杂手术的新型多功能图像引导手术（MIGS）平台。MIGS平台将在单个平台上集成高分辨率深度分辨光学成像系统、激光手术刀、微型多轴平移系统、图像处理器和控制系统。在外科手术过程中能够以微米分辨率看到埋藏的组织平面和血管具有革新涉及去除不同组织之间的粘连的外科手术的潜力。存在组织彼此粘附的许多情况。这些患者包括既往接受过手术、接受过放射治疗、患有肿瘤或炎症的患者。当组织平面被这些过程消除时，需要进行手术的外科医生处于严重的劣势，因为缺乏他们所依赖的正常组织平面引导来识别和对各种器官进行手术。当盲目地切入这些类型的手术区域时，可能会发生伤害，并可能产生毁灭性的后果。在某些情况下，致密粘连和组织损伤的结合使外科医生无法实现其目标，使一些疾病过程无法得到治疗。到目前为止，还没有技术可以在这个过程中指导外科医生。拟议的MIGS平台将使外科医生能够在没有某种形式的指导的情况下进行目前无法进行或非常危险的手术。MIGS平台的开发将通过实现以下特定目标来完成，1）开发一种紧凑且坚固的3D光学成像探头，该探头针对图像引导手术应用进行了优化，2）将光纤激光手术刀与成像探头集成，以进行精确的组织切割，以及3）在腹部粘连的体内大鼠模型中测试MIGS平台的性能。 公共卫生相关性：拟议的研究工作解决了一个重要的医疗需要的图像引导手术仪器，这将使手术，目前是不可能的或非常危险的。所提出的仪器的开发将使外科医生能够以前所未有的精度和准确度可视化和精确地放置切口。如果拟议工作的目标得到满足，多功能手术导航系统将可用于执行精细和复杂的手术。

DESCRIPTION (provided by applicant): The overall objective of the proposed project is the development of a novel Multifunctional Image Guided Surgical (MIGS) platform for performing delicate and intricate surgeries. The MIGS platform will integrate a high resolution depth- resolved optical imaging system, a laser scalpel, a miniature multi-axis translation system, an image processor, and a control system on a single platform. Being able to see buried tissue planes and blood vessels with micrometer resolution during surgical procedures has the potential to revolutionize surgical procedures that involve removal of adhesion between different tissues. There are many scenarios where tissues are adherent to one another. These include patients who have had prior surgeries, been radiated, have tumors or inflammatory processes. When tissue planes are obliterated by these processes, surgeons needing to conduct operations are at a serious disadvantage for lack of the normal tissue plane guidance they rely on to identify and operate upon various organs. When blindly cutting into these types of operative fields injuries can occur that can have devastating consequences. In some circumstances, the combination of dense adhesions and tissue injury preclude surgeons from accomplishing their objectives, leaving some disease processes untreated. To date, no technology exists to guide surgeons during this process. The proposed MIGS platform will enable surgeons to perform surgeries that cannot be currently performed or are very risky without some form of guidance. The development of the MIGS platform will be done by accomplishing the following specific aims, 1) Develop a compact and robust 3D optical imaging probe that is optimized for image guided surgical applications, 2) Integrate a fiber laser scalpel with the imaging probe for precision tissue cutting, and 3) Test the performance of the MIGS platform in an in vivo rat model of abdominal adhesions. PUBLIC HEALTH RELEVANCE: The proposed research work addresses an important medical need of an imaged guided surgical instrument which will enable surgeries that are currently not possible or are very risky. The development of the proposed instrument will enable surgeons to visualize and precisely place incision with unprecedented precision and accuracy. If the objectives of the proposed work are met a multifunctional surgical guidance system will be available for performing delicate and intricate surgeries.