Multifunctional Image Guided Surgical Platform

描述(由申请人提供)：建议项目的总体目标是开发一种新型的多功能图像引导外科(MIGS)平台，用于进行精细和复杂的手术。米格斯平台将在单一平台上集成高分辨率深度分辨光学成像系统、激光手术刀、微型多轴平移系统、图像处理器和控制系统。在外科手术过程中，能够以微米分辨率看到埋在地下的组织平面和血管，这有可能彻底改变涉及去除不同组织之间粘连的外科手术。在很多情况下，纸巾会互相粘连。这些患者包括以前做过手术、接受过辐射、有肿瘤或炎症过程的患者。当组织平面被这些过程破坏时，需要进行手术的外科医生处于严重的劣势，因为他们缺乏正常的组织平面指导来识别和操作各种器官。当盲目切入这些类型的手术区域时，可能会发生伤害，这可能会造成毁灭性的后果。在某些情况下，致密的粘连和组织损伤的结合阻碍了外科医生完成他们的目标，使得一些疾病过程得不到治疗。到目前为止，还没有技术可以在这个过程中指导外科医生。拟议的MiGs平台将使外科医生能够在没有某种形式的指导的情况下进行目前无法进行或非常危险的手术。MIGS平台的开发将通过实现以下具体目标来完成：1)开发紧凑且坚固耐用的3D光学成像探头，这种探头针对图像引导手术应用进行了优化；2)将光纤激光手术刀与成像探头集成在一起，以进行精确的组织切割；以及3)在大鼠腹壁粘连的活体模型中测试MIGS平台的性能。公共卫生相关性：拟议的研究工作解决了成像引导手术器械的一个重要医疗需求，该器械将使目前不可能或非常危险的手术成为可能。拟议的仪器的开发将使外科医生能够以前所未有的精确度和精确度可视化并精确地放置切口。如果达到拟议工作的目标，一个多功能的手术指导系统将可用于进行精细和复杂的手术。

DESCRIPTION (provided by applicant): The overall objective of the proposed project is the development of a novel Multifunctional Image Guided Surgical (MIGS) platform for performing delicate and intricate surgeries. The MIGS platform will integrate a high resolution depth- resolved optical imaging system, a laser scalpel, a miniature multi-axis translation system, an image processor, and a control system on a single platform. Being able to see buried tissue planes and blood vessels with micrometer resolution during surgical procedures has the potential to revolutionize surgical procedures that involve removal of adhesion between different tissues. There are many scenarios where tissues are adherent to one another. These include patients who have had prior surgeries, been radiated, have tumors or inflammatory processes. When tissue planes are obliterated by these processes, surgeons needing to conduct operations are at a serious disadvantage for lack of the normal tissue plane guidance they rely on to identify and operate upon various organs. When blindly cutting into these types of operative fields injuries can occur that can have devastating consequences. In some circumstances, the combination of dense adhesions and tissue injury preclude surgeons from accomplishing their objectives, leaving some disease processes untreated. To date, no technology exists to guide surgeons during this process. The proposed MIGS platform will enable surgeons to perform surgeries that cannot be currently performed or are very risky without some form of guidance. The development of the MIGS platform will be done by accomplishing the following specific aims, 1) Develop a compact and robust 3D optical imaging probe that is optimized for image guided surgical applications, 2) Integrate a fiber laser scalpel with the imaging probe for precision tissue cutting, and 3) Test the performance of the MIGS platform in an in vivo rat model of abdominal adhesions. PUBLIC HEALTH RELEVANCE: The proposed research work addresses an important medical need of an imaged guided surgical instrument which will enable surgeries that are currently not possible or are very risky. The development of the proposed instrument will enable surgeons to visualize and precisely place incision with unprecedented precision and accuracy. If the objectives of the proposed work are met a multifunctional surgical guidance system will be available for performing delicate and intricate surgeries.