MRS/MRI for Small Animal Models of Disease

MRS/MRI 用于小动物疾病模型

• 批准号: 7595353
• 负责人: JAMES H. PRESTEGARD
• 金额: $ 50万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7595353
• 关键词: Animal Disease Models; Animal Model; Animals; Communities; Data Quality; Development; Diabetes Mellitus; Disease; Funding; Genome Mappings; Image; Infection; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Mammals; Modeling; Monitor; Mus; Neurodegenerative Disorders; Obesity; Physiological; Population; Procedures; Protocols documentation; Rattus; Research; Scientist; System; Time; United States National Institutes of Health; Universities; Variant; base; combat; human disease; improved; in vivo; non-invasive monitor; public health relevance

DESCRIPTION (provided by applicant): The purchase of a magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) system for the in vivo study of small animals (primarily mice and rats) is proposed. The system will be based on a 7 Tesla, 210 mm horizontal bore magnet and a versatile console that can adapt to a variety of experimental protocols. The system will be used by an interdisciplinary group of 22 scientists, primarily at the University of Georgia, in support of their research on mouse and other small animal models of human disease. Their research, much of it already funded by the NIH, requires accurate monitoring of anatomical and physiological changes in animals during the course of a study. Traditionally, this is done by histological procedures on animals sacrificed at various times during a study. However, in time course studies, sacrifice introduces the effects of population variations, degrading the quality of data and requiring observations on multiple animals to restore statistical validity. The MRI/MRS system will provide a versatile alternative that allows in vivo imaging of anatomical features and the non-invasive monitoring of metabolite levels that can correlate with disease. PUBLIC HEALTH RELEVANCE: The use of small animal models for the study of normal development, of progression of human disease, and of treatment of human disease, has become widespread in the scientific community. This is particularly true in the case of mouse and rat models, where the availability of near complete maps of the genomes is greatly facilitating an ability to extrapolate results to other mammals. Improving the quality of data in these studies, through the use of MRI/MRS, will benefit our ability to combat and understand human diseases, including cancer, diabetes, obesity, circulatory disease, neurodegenerative disease, and pathogenic infection.

描述(由申请人提供)：建议购买磁共振成像(MRI)和磁共振波谱(MRS)系统，用于小动物(主要是小鼠和大鼠)的活体研究。该系统将基于一个7特斯拉，210毫米水平孔磁铁和一个多功能的控制台，可以适应各种实验协议。该系统将被一个由22名科学家组成的跨学科小组使用，主要是在佐治亚大学，以支持他们对老鼠和其他人类疾病小动物模型的研究。他们的研究，其中大部分已经由美国国立卫生研究院资助，需要在研究过程中准确监测动物的解剖和生理变化。传统上，这是通过对在研究期间不同时间牺牲的动物进行组织学程序来完成的。然而，在时间进程研究中，牺牲引入了种群变化的影响，降低了数据质量，需要对多个动物进行观察才能恢复统计有效性。MRI/MRS系统将提供一种多功能的替代方案，允许对解剖特征进行活体成像，并对可能与疾病相关的代谢物水平进行非侵入性监测。 公共卫生相关性：使用小动物模型研究正常发育、人类疾病的进展和人类疾病的治疗，在科学界已变得普遍。在小鼠和大鼠模型中尤其如此，在这些模型中，近乎完整的基因组图谱的可获得性极大地促进了将结果推断到其他哺乳动物的能力。通过使用MRI/MRS提高这些研究中的数据质量，将有助于我们对抗和了解人类疾病，包括癌症、糖尿病、肥胖症、循环系统疾病、神经退行性疾病和病原性感染。