INBRE: MUSC: ENHANCEMENT OF BIOENGINEERING PROGRAM AT MUSC

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 五年多来，南卡罗来纳州的三个研究机构(CRU)一直致力于促进再生医学、生物工程和发育生物学的INBRE主题。克莱姆森和南加州大学在生物工程方面的联合计划，在克莱姆森、南加州大学和南加州大学设立再生医学捐赠教席，以及联合科布雷赠款，都突显了这一努力。这些努力改善了BRIN/INBRE网络内的沟通、互动和研究环境。在这次更新中，每个CRU将管理一个互动的研究/技术核心单位，其目的将是与PUI的教职员工和学生建立和协调专门的研究团队/伙伴关系，并协助招聘新教师。具体地说，我们将在南加州大学提供干细胞核心单元，其目标/目的不仅是提供广泛的实践培训，而且通过每月的研讨会，从概念上了解干细胞的类型、它们的基本生物学，以及它们如何用于研究黏附、迁移、增殖的机制，或应用于组织工程或基因工程，或用于筛选环境毒素或药物。MUSC的核心教职员工将在PUI项目开发方面提供协助和合作。已经建立了具体的可变复杂性的实验模型，通过该模型，PUI教师可以选择成为竞争研究团队的一部分，或者使用这些模型来开发独立和相互依赖的研究项目。其中一种模式是最先进的单(干细胞)移植模式，全世界只有四到五家机构可以使用这种模式。所有合作项目和辅导的一个主要目标是，这些工作可以由PUI的教员在他们的家乡机构完成和维持。在MUSC，我们的招聘工作将致力于成功招聘两名少数族裔科学家(非裔美国人和西班牙裔)，目标是增加我们在干细胞生物学方面的竞争资金实力，并确保INBRE计划促进的长期持续合作。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For over five years, the three research institutions (CRUs) in South Carolina have been working to promote the INBRE theme of regenerative medicine, bioengineering, and developmental biology. This effort is highlighted by joint programs in bioengineering between Clemson and MUSC, the establishment of endowed chairs in regenerative medicine at Clemson, MUSC and USC and joint COBRE grants. These efforts have resulted in better communications, interactions, and research environment within the BRIN/INBRE network. In this renewal, each CRU will manage an interactive Research/Technological Core Unit whose purposes will be to build and coordinate specialized research teams/partnerships with PUI faculty and students and to assist in recruiting new faculty. Specifically, at MUSC, we will provide a Stem Cell Core Unit whose goals/aims will be to provide not only extensive hands-on training but also, through monthly seminars, conceptual understanding of the types of stem cells, their basic biology, and how they can be used to study mechanisms of adhesion, migration, proliferation, or applied to tissue or genetic engineering or to screening environmental toxins or drugs. MUSC Core faculty and staff will assist and collaborate in PUI project development. Specific experimental models of variable complexity have been established by which PUI faculty can elect to become a part of a competitive research team or use the models to develop independent and interdependent research programs. One of these models is a state-of-the-art, single (stem) cell engraftment model that is available at only four or five institutions worldwide. A major objective of all collaborative projects and mentoring will be that the work can be done and sustained by PUI faculty at their home institutions. At MUSC, our recruitment efforts will be committed to successfully recruiting two minority scientists (African American and Hispanic) with goals being to increase our competitive funding strengths in stem cell biology and to assure long term continuation of collaborations fostered by the INBRE program.