INBRE: MUSC: ENHANCEMENT OF BIOENGINEERING PROGRAM AT MUSC

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 五年多来，南卡罗来纳州的三个研究机构（CRU）一直致力于促进再生医学、生物工程和发育生物学的INBRE主题。 克莱姆森和南加州大学之间的生物工程联合项目，在克莱姆森、南加州大学和南加州大学建立再生医学教授职位，以及联合COBRE赠款，都突出了这一努力。 这些努力导致BRIN/INBRE网络内更好的沟通，互动和研究环境。在这次更新中，每个CRU将管理一个互动的研究/技术核心单元，其目的是建立和协调专业的研究团队/与PUI教师和学生的合作伙伴关系，并协助招聘新的教师。具体来说，在MUSC，我们将提供一个干细胞核心单元，其目标/目的不仅是提供广泛的实践培训，而且通过每月的研讨会，对干细胞类型的概念理解，它们的基本生物学，以及它们如何用于研究粘附，迁移，增殖的机制，或应用于组织或遗传工程或筛选环境毒素或药物。MUSC核心教师和工作人员将协助和PUI项目开发合作。 已经建立了可变复杂性的具体实验模型，PUI教师可以选择成为一个有竞争力的研究团队的一部分，或使用模型来开发独立和相互依存的研究项目。其中一种模型是最先进的单（干）细胞移植模型，全世界只有四五个机构提供。 所有合作项目和指导的一个主要目标是，这项工作可以由PUI教师在他们的家乡机构完成和维持。 在MUSC，我们的招聘工作将致力于成功招募两名少数民族科学家（非洲裔美国人和西班牙裔），目标是提高我们在干细胞生物学方面的竞争力，并确保INBRE计划培养的长期合作持续下去。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. For over five years, the three research institutions (CRUs) in South Carolina have been working to promote the INBRE theme of regenerative medicine, bioengineering, and developmental biology. This effort is highlighted by joint programs in bioengineering between Clemson and MUSC, the establishment of endowed chairs in regenerative medicine at Clemson, MUSC and USC and joint COBRE grants. These efforts have resulted in better communications, interactions, and research environment within the BRIN/INBRE network. In this renewal, each CRU will manage an interactive Research/Technological Core Unit whose purposes will be to build and coordinate specialized research teams/partnerships with PUI faculty and students and to assist in recruiting new faculty. Specifically, at MUSC, we will provide a Stem Cell Core Unit whose goals/aims will be to provide not only extensive hands-on training but also, through monthly seminars, conceptual understanding of the types of stem cells, their basic biology, and how they can be used to study mechanisms of adhesion, migration, proliferation, or applied to tissue or genetic engineering or to screening environmental toxins or drugs. MUSC Core faculty and staff will assist and collaborate in PUI project development. Specific experimental models of variable complexity have been established by which PUI faculty can elect to become a part of a competitive research team or use the models to develop independent and interdependent research programs. One of these models is a state-of-the-art, single (stem) cell engraftment model that is available at only four or five institutions worldwide. A major objective of all collaborative projects and mentoring will be that the work can be done and sustained by PUI faculty at their home institutions. At MUSC, our recruitment efforts will be committed to successfully recruiting two minority scientists (African American and Hispanic) with goals being to increase our competitive funding strengths in stem cell biology and to assure long term continuation of collaborations fostered by the INBRE program.