CORE A2 - MUSC MENTORING CORE

核心 A2 - MUSC 指导核心

• 批准号: 8168478
• 负责人: ROGER R MARKWALD
• 金额: $ 12.4万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8168478
• 关键词: Address; Advisory Committees; Angiogenic Factor; Area; Arts; Biocompatible Materials; Cells; Centers of Research Excellence; Committee Members; Complement; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Coupling; Developmental Biology; Endowment; Engineering; Funding; Goals; Grant; Health Care Costs; Histology; Human; Hyaluronan; Institution; Lasers; Medical; Medicine; Mentors; Molecular; Morbidity - disease rate; Muscle Cells; Nerve Regeneration; Pattern; Records; Recruitment Activity; Regenerative Medicine; Regulation; Research; Research Infrastructure; Research Personnel; Resources; Source; South Carolina; Stem cells; Surgeon; Testing; Tissue Engineering; Tissues; Training; United States National Institutes of Health; Universities; Vascular Graft; base; bone morphogenetic protein 4; cellular imaging; clinically relevant; design; economic cost; end-stage organ failure; functional restoration; mortality; novel; response; skills; tissue regeneration

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this COBRE proposal is to increase the number of NIH-supported biomedical researchers in the state of South Carolina, particularly at Clemson University (CU). For this purpose, CU's unique strengths in biomaterials and tissue engineering will be complemented by expertise in medicine and developmental biology at the Medical University of South Carolina (MUSC) and the University of South Carolina (USC) to establish a Center of Biomaterials for Tissue Regeneration (CBTR) at CU. To accomplish the center's goal, an outstanding cadre of mentors will mentor junior investigators toward independence as NIH-supported investigators. The center's tissue-regeneration theme simultaneously fits South Carolina's strength in regenerative medicine while addressing a significant cause of mortality and morbidity worldwide: End-stage organ failure and tissue loss create healthcare costs of nearly $400 billion annually in the US alone. Research in tissue regeneration offers the possibility of relief for these human and economic costs through restoration of functional tissues. The scientific focus of this center will be regulation of tissue regeneration through cell biomaterials interactions. Four projects from junior investigators have been rigorously selected to fit this theme. These projects are 1) Stem cell-myocyte electrical coupling via a laser-patterned cell bridge; 2) Biomaterials for guided neural regeneration; 3) BMP-4 as a novel angiogenic factor and its potential use in tissue engineering; and 4) Endothelial response-guided design of hyaluronan-based vascular grafts. These target investigators will be paired with mentors who are established, NIH-supported researchers with excellent track records in mentoring and with surgeons who will keep projects clinically relevant. The projects will be supported by a well-organized infrastructure and three state-of-the-art core facilities (Materials Synthesis, Characterization and Testing, Histology and Imaging, and Cell and Molecular Engineering). We have unprecedented state and institutional support to establish this center. CU will recruit three junior investigators to expand activities of this center. The state of South Carolina has also approved $2M at each institution (CU, MUSC, and USC) to support endowed chairs in regenerative medicine; the endowments have been matched by each institution to yield a total of $12M. Our nationally recognized External Advisory Committee members will critically evaluate the center's progress. This COBRE will significantly augment collaborative efforts in South Carolina to recruit, train, and retain a critical mass of investigators with cross-disciplinary skills to collaborate effectively in the research area of regenerative medicine.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该 COBRE 提案的主要目标是增加南卡罗来纳州、特别是克莱姆森大学 (CU) 受 NIH 支持的生物医学研究人员的数量。为此，CU 在生物材料和组织工程方面的独特优势将得到南卡罗来纳医科大学 (MUSC) 和南卡罗来纳大学 (USC) 医学和发育生物学专业知识的补充，在 CU 建立组织再生生物材料中心 (CBTR)。为了实现该中心的目标，一支优秀的导师队伍将指导初级研究人员作为 NIH 支持的研究人员走向独立。该中心的组织再生主题既符合南卡罗来纳州在再生医学方面的优势，又解决了全球死亡和发病的一个重要原因：仅在美国，终末期器官衰竭和组织损失每年就造成近 4000 亿美元的医疗费用。组织再生研究为通过功能组织的恢复来减轻这些人力和经济成本提供了可能性。该中心的科学重点是通过细胞生物材料相互作用调节组织再生。初级研究人员精心挑选了四个项目来适应这一主题。这些项目是 1) 通过激光图案细胞桥实现干细胞-肌细胞电耦合； 2）引导神经再生的生物材料； 3）BMP-4作为一种新型血管生成因子及其在组织工程中的潜在应用； 4) 基于透明质酸的血管移植物的内皮反应引导设计。这些目标研究人员将与知名导师、NIH 支持的研究人员（在指导方面拥有良好记录）以及保持项目临床相关性的外科医生配对。这些项目将得到组织良好的基础设施和三个最先进的核心设施（材料合成、表征和测试、组织学和成像以及细胞和分子工程）的支持。我们为建立这个中心提供了前所未有的国家和机构支持。 CU 将招募三名初级研究员来扩大该中心的活动。南卡罗来纳州还批准向每个机构（CU、MUSC 和 USC）拨款 200 万美元，以支持再生医学领域的捐赠主席；每个机构都匹配了捐赠，总计产生了 1200 万美元。我们国家认可的外部咨询委员会成员将严格评估该中心的进展。该 COBRE 将显着增强南卡罗来纳州的合作努力，招募、培训和保留大量具有跨学科技能的研究人员，以便在再生医学研究领域进行有效合作。