SC COBRE for Developmentally Based Cardiovascular Diseases

SC COBRE 针对发育性心血管疾病

• 批准号: 8305805
• 负责人: ROGER R MARKWALD
• 金额: $ 109.77万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305805
• 关键词: SC; COBRE; Developmentally; Based; Cardiovascular

This COBRE Phase III renewal is aimed at sustaining the research infrastructure built during the first ten years of NCRR funding. Our COBRE "Cardiovascular Developmental Biology Center" has become a nationally recognized, collaborative center with exclusive strengths in developmentally-related, cardiovascular diseases. Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development; investigating the developmental basis of adult cardiovascular diseases; and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering. COBRE accomplishments towards these three "cradle to grave" goals include the recruitment of 8 new faculty, mentoring and training of 23 COBRE target faculty, and the development of 3 research core facilities. Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful renewal of a statewide INBRE award in regenerative medicine, and funding of a translational award by the Leducq Foundation to create a Transatlantic Research Network exploring genetic mechanisms for valve diseases. For this PSO application, the plan for the Center transitioning to being independent of NIH/NCRR support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A ten Step, five year strategic plan including implementing fee structures, pilot projects, outreach activities and programmatic development is proposed to sustain the CDBC/COBRE center and its three scientific cores (Morphology, Imaging and Instrumentation Core, Proteogenomics and Bioinformatics Core, and Gene Function Core). An Administrative Core, led by the founding director of MUSC's Cardiovascular COBRE, is home to the Program Coordinator and the Internal Advisory Committee. Together, they will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Associate Provost for Research and Dean of the College of Medicine - exceeding one million dollars - help ensure programmatic growth development, and long-term sustainability of the Center.

COBRE第三阶段的更新旨在维持NCRR资助的前十年建立的研究基础设施。我们的COBRE“心血管发育生物学中心”已成为全国公认的合作中心，在发育相关的心血管疾病方面具有独特的优势。中心的研究有三个基本主题：了解正常和异常心脏和血管发育的机制；探讨成人心血管疾病的发病基础；并将正常心血管发育生物学的原理应用于再生医学或基于干细胞的组织工程。COBRE在实现这三个“从摇篮到坟墓”的目标方面取得的成就包括招聘8名新教师，指导和培训23名COBRE目标教师，以及开发3个研究核心设施。项目成果包括28个针对教师的独立研究奖，bb10410份同行评审出版物，南卡罗来纳州经济卓越中心（COEE）授予再生医学和高级组织生物制造领域的6个捐赠主席，与克莱姆森大学和南卡罗来纳大学合作共享，国家科学基金会研究基础设施改善奖，建立全州组织制造联盟，参与成功更新全州再生医学INBRE奖，并资助Leducq基金会设立一个转化奖，以创建一个跨大西洋研究网络，探索瓣膜疾病的遗传机制。对于这个PSO申请，中心在未来五年内过渡到独立于NIH/NCRR支持的计划是加强和升级我们的核心技术，提高它们的竞争力以吸引更多的使用（和成本回收），并促进与我们中心的新研究合作，从而提交有竞争力的研究申请，扩大我们在全州范围内的推广，特别是与其他IDeA中心的推广。为了维持CDBC/COBRE中心及其三个科学核心（形态学、成像和仪器核心、蛋白质基因组学和生物信息学核心以及基因功能核心）的发展，提出了一项为期10年、为期5年的战略计划，包括实施收费结构、试点项目、推广活动和规划发展。由MUSC心血管COBRE创始主任领导的行政核心是项目协调员和内部咨询委员会的所在地。它们将共同成为该中心的主要业务部门。外部咨询委员会将对中心的进展进行持续的评估和评价。研究副教务长和医学院院长的机构承诺-超过一百万美元-有助于确保项目增长发展和中心的长期可持续性。