SC COBRE for Developmentally Based Cardiovascular Diseases

SC COBRE 针对发育性心血管疾病

• 批准号: 8305805
• 负责人: ROGER R MARKWALD
• 金额: $ 109.77万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305805
• 关键词: SC; COBRE; Developmentally; Based; Cardiovascular

This COBRE Phase III renewal is aimed at sustaining the research infrastructure built during the first ten years of NCRR funding. Our COBRE "Cardiovascular Developmental Biology Center" has become a nationally recognized, collaborative center with exclusive strengths in developmentally-related, cardiovascular diseases. Three underlying themes define the Center's research: understanding mechanisms of normal and abnormal heart and vascular development; investigating the developmental basis of adult cardiovascular diseases; and applying the principles of normal cardiovascular developmental biology to regenerative medicine or stem cell-based, tissue engineering. COBRE accomplishments towards these three "cradle to grave" goals include the recruitment of 8 new faculty, mentoring and training of 23 COBRE target faculty, and the development of 3 research core facilities. Programmatic outcomes include 28 independent research awards to target faculty, >410 peer reviewed publications, the State of South Carolina Center of Economic Excellence (COEE) awarding six endowed chairs in Regenerative Medicine and Advanced Tissue Biofabrication shared in partnerships with Clemson and the University of South Carolina, an NSF Research Infrastructure Improvement award to establish a statewide alliance in tissue fabrication, participation in the successful renewal of a statewide INBRE award in regenerative medicine, and funding of a translational award by the Leducq Foundation to create a Transatlantic Research Network exploring genetic mechanisms for valve diseases. For this PSO application, the plan for the Center transitioning to being independent of NIH/NCRR support during the next five years is to enhance and upgrade our core technologies, to increase their competitiveness to attract greater usage (and cost recovery), and to promote new research collaborations with our Center that can lead to submission of competitive research applications and broaden our statewide outreach, especially to other IDeA centers. A ten Step, five year strategic plan including implementing fee structures, pilot projects, outreach activities and programmatic development is proposed to sustain the CDBC/COBRE center and its three scientific cores (Morphology, Imaging and Instrumentation Core, Proteogenomics and Bioinformatics Core, and Gene Function Core). An Administrative Core, led by the founding director of MUSC's Cardiovascular COBRE, is home to the Program Coordinator and the Internal Advisory Committee. Together, they will act as the main operational arm of the Center. An External Advisory Committee will provide ongoing assessment and evaluation of the Center's progress. Institutional commitments from the Associate Provost for Research and Dean of the College of Medicine - exceeding one million dollars - help ensure programmatic growth development, and long-term sustainability of the Center.

这次Cobre第三阶段的更新旨在维持在NCRR资助的前十年建立的研究基础设施。我们的科布雷“心血管发育生物学中心”已成为国家认可的合作中心，在与发育相关的心血管疾病领域拥有独特的优势。该中心的研究有三个基本主题：了解正常和异常心脏和血管发育的机制；调查成人心血管疾病的发育基础；将正常心血管发育生物学的原理应用于再生医学或基于干细胞的组织工程。Cobre在实现这三个“从摇篮到坟墓”目标方面取得的成就包括招聘了8名新教师，指导和培训了23名Cobre目标教师，并开发了3个研究核心设施。计划成果包括向目标教师颁发28个独立研究奖，发表410篇同行评议的出版物，南卡罗来纳州经济卓越中心(COEE)授予与克莱姆森和南卡罗来纳大学合作分享的再生医学和先进组织生物制造方面的六个捐赠教席，获得NSF研究基础设施改善奖以建立全州组织制造联盟，参与成功续签全州再生医学INBRE奖，以及由Leducq基金会资助翻译奖，以创建一个探索瓣膜疾病遗传机制的跨大西洋研究网络。对于这一PSO应用程序，该中心计划在未来五年内过渡到独立于NIH/NCRR支持，以增强和升级我们的核心技术，提高它们的竞争力以吸引更多的使用(和成本回收)，并促进与我们中心的新研究合作，从而提交有竞争力的研究申请，并扩大我们在全州的覆盖面，特别是其他IDEA中心。提出了一个十步五年战略计划，包括实施收费结构、试点项目、外联活动和方案发展，以支持CDBC/Cobre中心及其三个科学核心(形态、成像和仪器核心、蛋白质基因组和生物信息学核心和基因功能核心)。由南加州大学心血管中心创始主任领导的行政核心是项目协调员和内部咨询委员会的所在地。它们将共同充当该中心的主要业务部门。一个外部咨询委员会将对中心的进展情况进行持续评估和评价。负责研究的副教务长和医学院院长的机构承诺--超过100万美元--有助于确保中心的方案增长、发展和长期可持续性。